Publications by authors named "Asli Kurden-Pekmezci"
Cell line development and bioreactor process optimization for an atezolizumab biosimilar.
Biotechnol Appl Biochem
December 2024
Article Synopsis
- Checkpoint inhibitors like atezolizumab are important immunotherapy drugs used to treat various cancers by targeting immune checkpoints.
- This study focused on producing atezolizumab using a specialized monoclonal cell line from Chinese hamster ovary cells, aiming to establish a reliable production process.
- After growing the cells in a bioreactor and purifying the antibody through chromatography, researchers compared the produced atezolizumab with the commercially available version to evaluate its characteristics.
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and the third leading cause of cancer-related deaths worldwide. Despite recent advances in treatment options, therapeutic management of HCC remains a challenge, emphasizing the importance of exploring novel targets. MALT1 paracaspase is a druggable signaling molecule whose dysregulation has been linked to hematological and solid tumors.
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