Publications by authors named "Aslankoc R"
Article Synopsis
- The study investigates the neuroprotective effects of Thymoquinone (TQ) and Metformin (MM) on Parkinson's disease by testing their effects separately and in combination on mice.* -
- Mice treated with TQ, MM, or both showed significant improvements in motor coordination and reduced markers of oxidative stress and neurodegeneration compared to the control group.* -
- Findings suggest that TQ and MM together may be more effective than either alone, providing evidence for their potential as a therapy for Parkinson's disease.*
Article Synopsis
- The study explored the effects of Vetiveria zizanioides oil (VET) on oxidative stress and cell death in rats that experienced seizures induced by pentylenetetrazol (PTZ).
- Four groups of rats were observed: a control group, a PTZ only group, and two groups receiving different doses of VET alongside the PTZ treatment.
- Findings indicated that PTZ increased seizure activity and caused oxidative stress, but treatment with VET significantly reduced these negative effects and improved the overall condition of the rats' brain tissues.
Article Synopsis
- - The study investigates how obesity and diabetes (type 1 and type 2) impact testosterone levels and oxidative stress in male rats, suggesting that oxidative stress might be key in this relationship.
- - Male Sprague-Dawley rats were divided into four groups (control, obesity, T1DM, and T2DM) and given different diets and treatments to induce metabolic conditions for comparing testosterone and oxidative stress markers.
- - Results showed that testosterone levels were significantly lower in T1DM and T2DM rats compared to the control and obesity groups, with oxidative stress markers indicating higher levels of stress in diabetic rats.
Article Synopsis
- Different functional foods, particularly whey proteins, are being studied for their potential benefits in managing Non-Alcoholic Fatty Liver Disease (NAFLD) due to their bioactive nutrients.
- In a study with male Wistar rats, it was found that whey protein supplementation did not significantly affect body weight but reduced abdominal circumference and overall liver damage in rats consuming a high fat-high fructose diet.
- The results suggest that whey protein may help improve liver health by lowering liver damage scores and increasing specific protein expression in the intestines, although it had no impact on certain inflammation markers related to liver health.
Side effects of doxorubicin (DOX) are mainly due to oxidative stress, with the involvement of inflammatory and apoptotic mechanisms. Agomelatine (AGO) is a melatonin receptor agonist with antioxidant, anti-inflammatory, and anti-apoptotic features. This study aimed to evaluate the effects of AGO with different doses on DOX-induced neurotoxicity.
View Article and Find Full Text PDFArticle Synopsis
- The study assessed how S. officinalis (sage) essential oil affects the growth, health, and antioxidant activity in common carp (C. carpio) over a 60-day period.
- Fish fed with 1 ml/kg of sage oil showed an increase in superoxide dismutase (SOD) activity, but overall growth performance and other health markers remained unchanged.
- Importantly, carp experienced no mortality when exposed to a bacteria challenge after being fed with the sage oil, suggesting it improves gut health, disease resistance, and fertility in the fish.
Article Synopsis
- The study explores how high fructose corn syrup (HFCS) negatively impacts memory and learning by impairing activity in the prefrontal cortex (PFC) of adolescent rats.
- Rats were divided into three groups: a control group, an HFCS group, and an HFCS plus vitamin D group, with various tests conducted to assess fluid intake, weight gain, and behavioral performance.
- Results showed that HFCS increased neuron degeneration and impaired memory functions, while vitamin D treatment reversed these negative effects, enhancing cholinergic activity and improving learning and memory.
Protective effect of pregabalin on renal and renal endothelial damage in sepsis induced by lipopolysaccharide.
Immunopharmacol Immunotoxicol
February 2024
Article Synopsis
- The study aimed to evaluate the protective role of pregabalin (PRG) against kidney and renal endothelial damage caused by sepsis induced by lipopolysaccharide (LPS) in rats.
- Results showed that LPS significantly worsened kidney function markers and increased oxidative stress, while adding PRG improved these markers and reduced inflammation and tissue damage.
- The findings suggest that PRG may help mitigate sepsis-related kidney damage and indicate potential for its use in preventive treatment, although further research is needed.
Article Synopsis
- Methotrexate (MTX) is an effective chemotherapy drug but can cause harmful side effects like neurotoxicity, which this study aims to address by evaluating the effects of ramelteon (RMLT).
- The research used 32 male rats divided into four groups to assess the impact of MTX alone versus MTX combined with RMLT, looking at various biochemical and cellular changes in the brain.
- Results showed that RMLT effectively reduced oxidative stress and inflammation caused by MTX, suggesting it could be a valuable supportive treatment for patients undergoing MTX therapy.
Article Synopsis
- This study aimed to determine how moderate-intensity swimming affects learning and memory using the Morris water maze test in aged rats.
- The experiment involved 32 male rats divided into four groups that either exercised or served as controls over an 8-week period.
- Results showed that exercise significantly enhanced swim speeds and increased expressions of important proteins (SIRT-1, CREB, BDNF) linked to memory improvement in older rats.
Article Synopsis
- The study examined how astaxanthin (AXA) helps counteract brain damage caused by methotrexate (MTX) in female rats, focusing on areas like the cerebral cortex and hippocampus.
- Rats were divided into three groups: control (saline), MTX only, and MTX with AXA, allowing researchers to analyze the effects of AXA on oxidative stress and histological changes in the brain.
- Results revealed that while MTX decreased antioxidant levels and caused tissue damage, AXA improved these oxidative stress indicators and reduced inflammation, suggesting protective benefits against MTX toxicity.
Article Synopsis
- Long-term cigarette smoking causes damage to liver tissue, and alpha-lipoic acid (ALA) may help reduce oxidative stress in the liver.
- The study involved 28 female rats divided into three groups: a control group exposed to fresh air, a smoking group exposed to cigarette smoke, and a smoking + ALA group receiving ALA treatment.
- Results showed that cigarette smoke exposure increased levels of oxidative damage (MDA) and liver enzymes (AST), while ALA treatment significantly improved these levels and enhanced antioxidant enzyme activity (CAT, SOD) compared to the smoking group.
Article Synopsis
- * Results showed that paracetamol increased oxidative stress and DNA damage in the liver, while treatment with resveratrol and avocado oil improved antioxidant levels and reduced these harmful effects.
- * The findings suggest that combining resveratrol and avocado oil can be effective in protecting the liver from paracetamol-induced toxicity, likely due to their antioxidant properties.
Article Synopsis
- The study aimed to explore if agomelatine (AGO) can prevent damage to testicular and epididymal tissues caused by methotrexate (MTX) in rats.
- Twenty-four male Wistar albino rats were divided into three groups: a control group, an MTX-only group, and an MTX+AGO group, which received AGO after MTX.
- Results showed that MTX led to significant tissue damage, increased oxidative stress, and inflammatory responses, while AGO treatment improved these harmful effects and helped restore normal tissue conditions.
Sepsis, systemic hyper-inflammatory immune response, causes the increase of morbidity and mortality rates due to multi-organ diseases such as neurotoxicity. Lipopolysaccharide (LPS) induces inflammation, oxidative stress and apoptosis to cause brain damage. We aimed to evaluate the antioxidant, anti-inflammatory and antiapoptotic effects of Agomelatine (AGM) on LPS induced brain damage via NF-kB signaling.
View Article and Find Full Text PDFArticle Synopsis
- - This study explored how melatonin (MLT) affects the male reproductive system when combined with high-fructose corn syrup (HFCS), using 36 male rats that were split into three groups: control, HFCS, and HFCS + MLT.
- - Results showed that long-term HFCS intake led to decreased epididymal weights, increased oxidative stress markers (MDA), and reduced antioxidant enzyme activities (SOD and CAT), causing testicular damage and lower sperm counts.
- - Melatonin administration improved oxidative stress by increasing SOD and CAT levels and reduced the harmful effects of HFCS, suggesting that melatonin could be an effective treatment for HFCS-induced testicular toxicity.
Article Synopsis
- - The study investigated the effects of lipopolysaccharide (LPS) on oxidative damage and inflammation in the brains of rats, focusing on the hippocampus and cerebellum, and examined the potential protective role of pregabalin (PG).
- - Researchers divided 24 female rats into three groups: a control group, a group treated with LPS to induce inflammation, and a group treated with both LPS and pregabalin. Key measurements included DNA damage and various blood and brain tissue markers related to oxidative stress and inflammation.
- - Results showed increased damage and inflammatory markers in the LPS-treated rats, but the group treated with LPS and pregabalin had lower oxidative stress levels, suggesting that pregabalin
Objective: The study was aimed to evaluate the physiopathological consideration of the effects of electromagnetic field (EMF) from the radiation of 4.5 G mobile phones on the liver tissue of rats and quercetin (Qu) applied as an antioxidant for reducing these effects.
Methods: Male Wistar-Albino rats were divided into four groups with 8 rats in each group.
Article Synopsis
- * Rats were divided into three groups: a control group, an EMR-only group, and an EMR + vitamin C group, with findings showing significant increases in oxidative stress markers in the EMR-only group.
- * Results indicated that vitamin C treatment significantly reduced oxidative stress and the expression of harmful proteins (Caspase-3 and Caspase-8) in the ovaries and uterus, suggesting it may offer protective benefits against EMR-induced damage.
This study investigated the long-term effects of electric fields (EF) which might cause physiopathological or morphological changes in the testis tissues of rats. We assumed that using resveratrol (RES) might reduce harmful effects of the EF. Thirty-two male Wistar Albino rats were randomly divided into four groups with eight animals in each; control, EF, EF + RES and RES.
View Article and Find Full Text PDFArticle Synopsis
- - The study aimed to assess how methotrexate (MTX) impacts the lungs through markers of inflammation and cell death, and to explore if gallic acid (GA) can offer protective effects.
- - Twenty-four male rats were divided into three groups: one receiving saline (control), one given MTX, and one treated with both MTX and GA. Various analyses assessed DNA damage, oxidative stress, and inflammation.
- - Results indicated that MTX significantly increased DNA damage and inflammatory markers in the lungs, while GA treatment reduced these harmful effects, suggesting that GA may have a protective role against MTX-induced lung damage.
Article Synopsis
- Recent studies highlight the rise of pancreatic disorders, with smoking identified as a potential risk factor, though the specific mechanisms remain unclear.
- This research involved 28 female rats divided into three groups to assess the effects of cigarette smoke exposure and the protective role of Alpha Lipoic Acid (ALA) on pancreatic damage.
- Results showed that cigarette smoke exposure increased serum amylase and glucose levels while decreasing insulin, suggesting damage to both endocrine and exocrine functions of the pancreas.
Article Synopsis
- The study investigates colon types and morphological changes in fetuses from 10 to 40 weeks gestation, focusing on those without external pathologies.
- It evaluates the types of colon in two parts: the segment between the ileal orifice and sigmoid colon, and the sigmoid colon itself, detailing the macroscopic measurements of wall thickness and diameter.
- Results show a significant variation in colon types across trimesters, with adult-type colons becoming more common in the third trimester, and notable development in structures like haustra and tenia coli as pregnancy progresses.
Article Synopsis
- - The study explored the morphologic structures of the jejunum and ileum in 131 human fetuses, analyzing various parameters such as size, localization, and thickness of intestinal layers at different gestational ages.
- - No significant differences related to sex were found, though macroscopic measurements increased with gestational age; the thickness of the tunica serosa remained stable.
- - The findings aim to enhance understanding of fetal intestinal development and could assist in diagnosing and treating related anomalies and pathologies.