Publications by authors named "Aslam S"

Cancer is a serious threat to human beings and is the second-largest cause of death all over the globe. Chemotherapy is one of the most common treatments for cancer; however, drug resistance and severe adverse effects are major problems associated with anticancer therapy. New compounds with multi-target inhibitory properties are targeted to surmount these challenges.

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Semen traits play the vital role in determining the fertility of a broiler breeder flock; however, it can be influenced by several factors. This experiment was carried out to assess some of these factors affecting the semen. A total of 89 male birds and 960 hens of 20-week-old broiler breeder (2215 g ± 7.

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Article Synopsis
  • The online food trading market faces security issues due to virtuality and information asymmetry, leading to a significant "lemon problem," which refers to poor quality goods being mixed with good quality ones.
  • An evolutionary game model was developed to analyze the interactions between sellers, buyers, and the trading platform, determining how various factors like subsidies and punishments influence strategies and contribute to the "lemon problem."
  • Results show that the strategies of participants in the market stabilize under certain conditions, with factors like cost differences and penalties being crucial in shaping their decisions, highlighting the need for a standardized regulatory system to improve market transparency and quality.
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Common variable immunodeficiency (CVID) is a primary immunodeficiency disorder that causes decreased immunity and increased susceptibility to infections. It affects B lymphocyte differentiation, resulting in predominantly bacterial and less frequently viral, fungal, and protozoal infections. The respiratory and gastrointestinal tracts where antibody defences are essential are usually affected.

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Aim: This study was conducted to compare the efficacy of using 0.5 mg/mL povidone-iodine solution as an irrigant and coolant in reducing postoperative sequelae like swelling, trismus, and pain with the conventional normal saline irrigation during the surgical removal of the impacted lower third molar.

Materials And Methods: The research was conducted out toward the MES Dental College in Perinthalmanna, Kerala, in the Department of Oral and Maxillofacial Surgery.

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Article Synopsis
  • The novel pathogen discussed is part of the Enterobacter genus, resistant to multiple antibiotics, and lacks effective drugs, highlighting the necessity for new treatment options.
  • A bacterial pan-genome analysis identified 2611 essential nonredundant proteins from the core proteomes of six strains, with 20 proteins classified as therapeutic targets due to their role in bacterial virulence.
  • Bioinformatic analysis led to the identification of five plant-derived compounds with potential as replication inhibitors against three important target proteins, paving the way for future experimental validation.
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A ternary oxide nanocomposite based on BiO/MgO/GO was prepared using a co-precipitation method for photoconductive device applications. The structure and morphology of the as-prepared nanocomposite were characterized analytically using X-ray diffraction (XRD), scanning electron microscopy (SEM), electron dispersive spectroscopy (EDS) techniques, and optical characterization was made using Fourier-transform infrared (FTIR) spectroscopy, photoluminescence (PL), and UV-vis spectroscopy techniques. The heterostructure of the crystal with a crystallite size of 28.

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Antimicrobial resistance (AMR) is a leading cause of treatment failure for many infectious diseases worldwide. Improper overdosing and the misuse of antibiotics contributes significantly to the emergence of drug-resistant bacteria. The co-contamination of heavy metals and antibiotic compounds existing in the environment might also be involved in the spread of AMR.

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A 7-day course of glecaprevir/pibrentasvir started in the preoperative period prevented transmission of hepatitis C virus (HCV) from viremic donors to 10 HCV-negative recipients (2 heart, 1 lung, 6 kidney, 1 heart/kidney) with 100% sustained virological response at 12 weeks.

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From the last few years mode of interactions between drugs and DNA is an attractive research area as it bridges chemistry, molecular biology and medicinal science. Interactions between small heterocyclic molecules and human DNA is a noteworthy feature in pharmacology for investigation of drugs mechanism and designing of more effective and target specific drugs with fewer side effects. The present research work focuses on the theoretical investigations of 3-benzoyl-4-hydroxy-2-methyl-2H-1, 2-benzothiazine (SASA) by using Gaussian (16 W) software to predict optimized geometry, HOMO-LUMO gap, bond length, bond angle, dihedral angle, electronic and vibrational spectra.

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Aims: The current study explored the anti-nociceptive activity of magnolol in post-incisional inflammatory nociceptive pain.

Main Methods: Preliminary, the anti-inflammatory, antioxidant, and cytoprotective potential of magnolol were confirmed against hydrogen peroxide (HO)-induced PC12 cells. Next, an in-vivo model of planter incision surgery was established in BALB/c mice.

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Introduction: COVID 19 pandemic has given rise to several challenges to clinicians and one of the keys in this is to predict the set of patients who progress from mild disease to moderate and severe. Apart from the symptomatology and signs, there are several lab parameters varying from biochemical, hematological to radiological parameters which help us in stratifying the stage of disease and also in deciding on which set of patients need close and vigilant monitoring. This would help us in better stratification of disease and utilize the available infrastructure and resources in an optimum way for better management of the disease.

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Introduction: Various classes of antibiotics have been linked to causing a wide range of neuropsychiatric symptoms. These manifestations range from psychosis and delirium to encephalitis and intracranial hypertension. The prevalence of psychosis adverse drug reactions (ADRs) for individual antibiotics ranges from 0.

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Environmental pollutants present a potential source of toxicity when exposed to humans. The study was aimed at investigating the potential of (Roxb.) as a hepatoprotective agent in cadmium-induced hepatotoxicity causing lipid profile disturbance.

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Background And Objectives: The aim of this study is to assess clinical and pathologic correlations of jaw tremor in 3 cohorts enrolled in a long-term aging study. Jaw/lip tremor has been described in various movement disorders but the impact of seeing a jaw tremor on clinician diagnosis and whether the presence of isolated jaw tremor is correlated with subsequent phenoconversion to a different movement disorder are unclear.

Methods: Data from the Arizona Study of Aging and Neurodegenerative Disease, a longitudinal clinicopathologic study, were used.

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The exponential growth of the edge-based Internet-of-Things (IoT) services and its ecosystems has recently led to a new type of communication network, the Low Power Wide Area Network (LPWAN). This standard enables low-power, long-range, and low-data-rate communications. Long Range Wide Area Network (LoRaWAN) is a recent standard of LPWAN that incorporates LoRa wireless into a networked infrastructure.

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The HIV latent viral reservoir (LVR) remains a major challenge in the effort to find a cure for HIV. There is interest in lymphocyte-depleting agents, used in solid organ and bone marrow transplantation to reduce the LVR. This study evaluated the LVR and T cell receptor repertoire in HIV-infected kidney transplant recipients using intact proviral DNA assay and T cell receptor sequencing in patients receiving lymphocyte-depleting or lymphocyte-nondepleting immunosuppression induction therapy.

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The cobas 5800 System ("cobas 5800") is a new low- to mid-throughput PCR-based nucleic acid testing system which performs both qualitative and quantitative testing, including viral load (VL) determination. cobas 5800 shares numerous design elements and technical characteristics with the existing cobas 6800/8800 Systems. We compared HBV, HCV, and HIV-1 VL results from cobas 5800 in three different laboratories to those from the same specimens tested on a cobas 6800 system.

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Unlabelled: We and others have previously shown that the SARS-CoV-2 accessory protein ORF6 is a powerful antagonist of the interferon (IFN) signaling pathway by directly interacting with Nup98-Rae1 at the nuclear pore complex (NPC) and disrupting bidirectional nucleo-cytoplasmic trafficking. In this study, we further assessed the role of ORF6 during infection using recombinant SARS-CoV-2 viruses carrying either a deletion or a well characterized M58R loss-of-function mutation in ORF6. We show that ORF6 plays a key role in the antagonism of IFN signaling and in viral pathogenesis by interfering with karyopherin(importin)-mediated nuclear import during SARS-CoV-2 infection both , and in the Syrian golden hamster model .

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Selenium nanoparticles (SeNPs) can be produced by biogenic, physical, and chemical processes. The physical and chemical processes have hazardous effects. However, biogenic synthesis (by microorganisms) is an eco-friendly and economical technique that is non-toxic to human and animal health.

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Oral fungal infections can be caused by certain species of fungi among which candida albicans is the most implicated. Oral candidiasis is correlated with multiple conditions, such as coronavirus disease-2019, oral leukoplakia and oral erythroplakia. Tenascin is a glycoprotein and is present at the site of tissue injury and chronic inflammation, and tends to be over-expressed in cases of malignancy.

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Objective: In response to an outbreak of circulating vaccine-derived poliovirus (cVDPV) type 2 in the Philippines in 2019-2020, several rounds of supplementary immunization activities using the monovalent type 2 oral poliovirus vaccine (OPV) were conducted for the first time in the Western Pacific Region. After use of the monovalent vaccine, the emergence of vaccine-derived poliovirus unrelated to the outbreak virus was detected in healthy children and environmental samples. This report describes the detection of this poliovirus in the Philippines after use of the monovalent type 2 OPV for outbreak response.

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Article Synopsis
  • The study aimed to segment CT images using a k-means clustering algorithm and extract textural features with the gray level co-occurrence matrix (GLCM).
  • It compared the effectiveness of machine learning classifiers (Naïve Bayes, Bagging, REPTree) to classify images as COVID or non-COVID, alongside three pre-trained CNN models (AlexNet, ResNet50, SqueezeNet).
  • The results showed that the Naïve Bayes classifier achieved a 97% accuracy, while the ResNet50 model led with 99%, indicating that deep learning networks were more effective than traditional machine learning methods for classifying COVID-19 images.
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Purpose: To quantify the effect of cataract on color vision as measured by the low-vision Cambridge Colour Test (lvCCT; Cambridge Research Systems) and to understand whether different types and severities of cataract have different effects on color vision.

Design: Cohort study.

Participants: Patients aged 18 to 95 undergoing routine cataract surgery at the Oxford Eye Hospital.

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