Publications by authors named "Aske L L Rosted"
Background: It is unknown whether skin biomarkers collected in infancy can predict the onset of atopic dermatitis (AD) and be used in future prevention trials to identify children at risk.
Objectives: This study sought to examine whether skin biomarkers can predict AD during the first 2 years of life.
Methods: This study enrolled 300 term and 150 preterm children at birth and followed for AD until the age of 2 years.
Background: There is currently no insight into biomarkers that can predict the onset of pediatric atopic dermatitis (AD).
Methods: Nested in a prospective birth cohort study that examined the occurrence of physician-diagnosed AD in 300 children, 44 random children with onset of AD in the first year of life were matched on sex and season of birth with 44 children who did not develop AD. Natural moisturizing factor (NMF), corneocyte surface protrusions, cytokines, free sphingoid bases (SBs) of different chain lengths and their ceramides were analyzed from tape strips collected at 2 months of age before onset of AD using liquid chromatography, atomic force microscopy, multiplex immunoassay, and liquid chromatography mass spectrometry, respectively.