Prenatal and Postnatal PCB-153 and ,'-DDE Exposures and Behavior Scores at 5–9 Years of Age among Children in Greenland and Ukraine.

Background: Studies have reported some evidence of adverse effects of organochlorine exposures on child development, but the results have been inconsistent, and few studies have evaluated associations with child behavior.

Objective: We investigated the association between prenatal and early-life exposures to 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) and 1,1-dichloro-2,2-bis(-chlorophenyl)-ethylene ('-DDE) and behaviors in children between 5 and 9 y of age.

Methods: In the Biopersistent organochlorines in diet and human fertility: Epidemiologic studies of time to pregnancy and semen quality in Inuit and European populations (INUENDO) cohort, consisting of mother-child pairs from Greenland and Ukraine (=1,018), maternal serum PCB-153 and '-DDE concentrations were measured during pregnancy, and cumulative postnatal exposures during the first 12 months after delivery were estimated using a pharmacokinetic model.