Publications by authors named "Asit K Mohanty"
Article Synopsis
- In gastrointestinal stromal tumors (GISTs), identifying specific genetic mutations is crucial for predicting treatment responses and disease outcomes.
- In a study of 95 GIST cases from the Kuwait Cancer Center, a significant majority (88%) had mutations, with most occurring in the gene, highlighting the need for targeted treatments.
- Wild-type GISTs (without mutations) appeared to be smaller and less aggressive, but their impact on disease progression was minimal, underscoring the importance of further regional studies to connect genetics with patient outcomes.
Objective: The three-tier grading scheme described in "The Papanicolaou Society of Cytopathology (PSC) System for reporting Pancreaticobiliary Cytopathology" (TPSCRPBC) which remained unchanged following the WHO Reporting System for Pancreaticobiliary Cytopathology (WRPBC) was evaluated on pancreatic adenocarcinomas (PACs) reported on endoscopic ultrasound-guided fine needle aspiration cytology (EUS-FNAC).
Methods: The Papanicolaou and May Grunwald Giemsa-stained smears from 116 cases of PACs were graded using the three-tier grading scheme laid down by TPSCRPBC/WRPBC. Cases exhibiting multiple grades were assigned primary, secondary and tertiary grades.
Background: Early detection of pancreatic adenocarcinomas is essential for improving survival. In this regard, endoscopic ultrasound-guided fine-needle aspiration cytology (EUS-FNAC) has established itself as the method of choice for its ability to target lesions smaller than those which could be targeted by the traditional imaging methods like transabdominal ultrasound. Identifying these tumors correctly on FNA may be challenging because pancreatic adenocarcinomas may show a wide range of morphological features and the presence of contaminants from the gastrointestinal tract may show up as potential pitfalls.
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