Publications by authors named "Asisa Dilger"
The nucleolus has core functions in ribosome biosynthesis, but also acts as a regulatory hub in a plethora of non-canonical processes, including cellular stress. Upon DNA damage, several DNA repair factors shuttle between the nucleolus and the nucleoplasm. Yet, the molecular mechanisms underlying such spatio-temporal protein dynamics remain to be deciphered.
View Article and Find Full Text PDFArticle Synopsis
- PARP1 is a key sensor for cellular damage, specifically DNA strand breaks, which helps in DNA repair by recruiting XRCC1 and forming repair complexes.
- The study shows that the recruitment of PARP1 and XRCC1 to DNA damage sites is mutually dependent, emphasizing their collaboration in responding to genotoxic stress.
- Experiments using various cell types revealed that XRCC1 KO cells are more sensitive to certain DNA-damaging treatments, and this sensitivity can be mitigated by further genetic modifications or pharmacological interventions targeting PARP1.