Fabrication and in vitro evaluation of bidirectional release and stability studies of mucoadhesive donut-shaped captopril tablets.

Objective: To obtain controlled release of captopril in the stomach, coated, mucoadhesive donut-shaped tablets were designed.

Materials And Methods: Donut-shaped tablet were made of different ratios of diluents to polymer or combination of polymers by direct compression method. Top and bottom portions of the tablet were coated with water-insoluble polymer followed by mucoadhesive coating.

In vitro-in vivo correlation and bioavailability studies of captopril from novel controlled release donut shaped tablet.

A controlled release formulation of captopril which was coated and fabricated into a donut shaped tablet formulation, was investigated in rabbit for pharmacokinetic and in vitro-in vivo correlation studies. Coated donut shaped tablets were prepared and in vitro release was studied in simulated gastric fluid at three different RPMs. New Zealand albino male rabbits have been used as animal model for in vivo study.

Niosome: A future of targeted drug delivery systems.

Over the past several years, treatment of infectious diseases and immunisation has undergone a revolutionary shift. With the advancement of biotechnology and genetic engineering, not only a large number of disease-specific biological have been developed, but also emphasis has been made to effectively deliver these biologicals. Niosomes are vesicles composed of non-ionic surfactants, which are biodegradable, relatively nontoxic, more stable and inexpensive, an alternative to liposomes.

Drug delivery system based on chronobiology--A review.

With the advancement in the field of chronobiology, modern drug delivery approaches have been elevated to a new concept of chronopharmacology i.e. the ability to deliver the therapeutic agent to a patient in a staggered profile.

Predictive QSAR modeling of HIV reverse transcriptase inhibitor TIBO derivatives.

Comparative quantitative structure-activity relationship (QSAR) studies have been carried out on tetrahydroimidazo[4,5,1-jk][1,4]benzodiazepine (TIBO) derivatives as reverse transcriptase inhibitors (n=70) using topological, structural, physicochemical, electronic and spatial descriptors. The data set was divided into training and test sets using a cluster-based method. Linear models were developed using multiple regression (with stepwise regression, factor analysis and genetic function approximation (GFA) as variable selection tools) and partial least squares (PLS) and combination of factor analysis and partial least squares (FA-PLS).

Development of linear and nonlinear predictive QSAR models and their external validation using molecular similarity principle for anti-HIV indolyl aryl sulfones.

Quantitative structure-activity relationship (QSAR) studies have been carried out on indolyl aryl sulfones, a class of novel HIV-1 non-nucleoside reverse transcriptase inhibitors, using physicochemical, topological and structural parameters along with appropriate indicator variables. The statistical tools used were linear methods (e.g.

Predictive QSAR modeling of CCR5 antagonist piperidine derivatives using chemometric tools.

Quantitative structure-activity relationship (QSAR) studies have been performed on piperidine derivatives (n = 119) as CCR5 antagonists. The whole data set was divided into a training set (75% of the dataset) and a test set (remaining 25%) on the basis of K-means clustering technique. Models developed from the training set were used to assess the predictive potential of the models using test set compounds.