Cu(I)-Catalyzed Silylation and Germylation of Azauracils.

The current study demonstrates a Cu(I) catalyzed direct C(sp)-H silylation and germylation of azauracil using triphenylsilane and triphenylgermane. A broad scope, excellent functional group tolerance, and suitability for large-scale reactions are exhibited in this protocol. Moreover, this method can be readily applied to structurally complex bioactive molecules.

Q factor: A measure of competition between the topper and the average in percolation and in self-organized criticality.

We define the Q factor in the percolation problem as the quotient of the size of the largest cluster and the average size of all clusters. As the occupation probability p is increased, the Q factor for the system size L grows systematically to its maximum value Q_{max}(L) at a specific value p_{max}(L) and then gradually decays. Our numerical study of site percolation problems on the square, triangular, and simple cubic lattices exhibits that the asymptotic values of p_{max}, though close, are distinct from the corresponding percolation thresholds of these lattices.

Magnetic phases of XY model with three-spin terms: interplay of topology and entanglement.

Magnetic and topological properties along with quantum correlations in terms of several entanglement measures have been investigated for an antiferromagnetic (AFM) spin-1/2 XY model in the presence of transverse magnetic field and XZX-YZY type of three-spin interactions. Symmetries of the spin Hamiltonian have been identified. Under the Jordan-Wigner transformation, the spin Hamiltonian converted into spinless superconducting model with nearest neighbor (NN) hopping and Cooper pairing terms in addition to next NN Cooper pairing potential.

Efficacy, Safety and Immunogenicity of Sun's Ranibizumab Biosimilar in Neovascular Age-Related Macular Degeneration: A Phase 3, Double-Blind Comparative Study.

Introduction: The study aimed to evaluate comparability in terms of efficacy, safety and immunogenicity of Sun's ranibizumab biosimilar with reference ranibizumab in patients with neovascular age-related macular degeneration (nAMD).

Methods: This prospective, randomised, double-blind, two-group, parallel-arm, multicentre, phase 3 comparative study included patients with nAMD ≥ 50 years, randomised (in a 2:1 ratio) in a double-blind manner to receive 0.5 mg (0.

Comparative study of the outcomes of newly developed polypropylene-based modified trabeculectomy and glaucoma shunt surgery in neovascular glaucoma.

Background: Neovascular glaucoma (NVG) is a secondary glaucoma with a poor visual prognosis. Trabeculectomy with antifibrotic agents, glaucoma drainage devices (GDDs), and cyclo-destructive procedures are recommended in patients who are refractory to medical management. However, due to the poor success rate of conventional trabeculectomy and the higher cost of GDDs, alternative procedures need to be looked at.

Topological phases of monolayer and bilayer depleted Lieb lattices.

Existence of nontrivial topological phases in a tight binding Haldane-like model on the depleted Lieb lattice is reported. This two-band model is formulated by considering the nearest-neighbor (NN), next-NN (NNN) and next-NNN hopping terms along with complex phase which breaks the time reversal symmetry of this semi-metallic system. Topological feature of this model is studied along with the presence of sublattice symmetry breaking staggered onsite energy.

Kinetic Models of Wealth Distribution with Extreme Inequality: Numerical Study of Their Stability against Random Exchanges.

In view of some recent reports on global wealth inequality, where a small number (often a handful) of people own more wealth than 50% of the world's population, we explored if kinetic exchange models of markets could ever capture features where a significant fraction of wealth can concentrate in the hands of a few as the market size approaches infinity. One existing example of such a kinetic exchange model is the Chakraborti or Yard-Sale model; in the absence of tax redistribution, etc., all wealth ultimately condenses into the hands of a single individual (for any value of ), and the market dynamics stop.

Central Retinal Artery Occlusion in COVID-Associated Mucormycosis.

Introduction: Significant surge of mucormycosis was reported in the Indian Subcontinent during the second wave of the COVID-19 pandemic. COVID-associated mucormycosis (CAM) was defined as the development of features of mucormycosis with prior or current history of COVID-19 infection. Rapid angioinvasion is an important characteristic of mucormycosis.

Sandpile Universality in Social Inequality: Gini and Kolkata Measures.

Social inequalities are ubiquitous and evolve towards a universal limit. Herein, we extensively review the values of inequality measures, namely the Gini () index and the Kolkata () index, two standard measures of inequality used in the analysis of various social sectors through data analysis. The Kolkata index, denoted as , indicates the proportion of the 'wealth' owned by (1-k) fraction of the 'people'.

Engineering topological phases of any winding and Chern numbers in extended Su-Schrieffer-Heeger models.

Simple route of engineering topological phases for any desired value of winding and Chern numbers is found in the Su-Schrieffer-Heeger (SSH) model by adding a further neighbor hopping term of varying distances. It is known that the standard SSH model yields a single topological phase with winding number, = 1. In this study it is shown that how one can generate topological phases with any values of winding numbers, for examples,ν=±1,±2,±3,…,in the presence of a single further neighbor term which preserves inversion, particle-hole and chiral symmetries.

Evaluation of post-operative dry eye in upper and lower eyelid reconstruction: A cross-sectional study.

Purpose: In cases of eyelid malignancies requiring full thickness excisional biopsy followed by reconstruction of the created defect, the Meibomian glands are lost. Post-operative varying degrees of dry eye disease (DED) are expected in such patients. The aim was to evaluate the objective and subjective statuses of DED in cases of full thickness eyelid reconstruction following excisional biopsy because of malignancies.

A Prospective Observational Study on Changes in Intraocular Pressure and Iridocorneal Angle Following the Use of Escitalopram and Amitriptyline.

Background: Depression has emerged as one of the prime morbidities affecting professional and personal lives worldwide. Antidepressants are one of the mainstays of management of depressive episodes. Although antidepressants are considered a safe class of drugs, the studies examining the effects of antidepressant prescription on intraocular pressure (IOP) have shown a propensity to increase IOP, but not consistently.

Prospective evaluation of wipe-out after glaucoma filtration surgery in eyes with split fixation.

Purpose: To assess the incidence and cause of idiopathic, irreversible loss of vision ("wipe-out") in the early post-operative period after glaucoma-filtration surgery in advanced glaucoma.

Methods: It was a prospective, interventional cohort study. Patients with advanced glaucoma and macular split fixation underwent either only trabeculectomy (group A) or combined phaco-emulsification with trabeculectomy (group B).

Late-stage -C-H alkenylation of 2-arylindazoles in aqueous medium by Manganese(i)-catalysis.

Earth-abundant and water-tolerant manganese(i) catalyzed alkenylation of 2-arylindazole with alkyl and aryl alkynes through C-H bond activation is described with a unique level of -selectivity. The reaction proceeds through the control of C3 nucleophilicity of 2-aryl indazoles. This method is applied to the late-stage functionalization of complex molecules including ethinylestradiol, norethisterone, and N-protected amino acid derivatives.

Study of COVID-19 epidemiological evolution in India with a multi-wave SIR model.

The global pandemic due to the outbreak of COVID-19 ravages the whole world for more than two years in which all the countries are suffering a lot since December 2019. In this article characteristics of a multi-wave SIR model have been studied which successfully explains the features of this pandemic waves in India. Origin of the multi-wave pattern in the solution of this model is explained.

Clinical outcome of orbital apex syndrome in COVID associated mucormycosis patients in a tertiary care hospital.

Aim: To share clinical pattern of presentation, the modalities of surgical intervention and the one month post-surgical outcome of rhino-orbito-mucormycosis (ROCM) cases.

Methods: All COVID associated mucormycosis (CAM) patients underwent comprehensive multidisciplinary examination by ophthalmologist, otorhinolaryngologist and physician. Patients with clinical and radiological evidence of orbital apex involvement were included in the study.

Kinetic exchange income distribution models with saving propensities: inequality indices and self-organized poverty level.

We report the numerical results for the steady-state income or wealth distribution [Formula: see text] and the resulting inequality measures (Gini [Formula: see text] and Kolkata [Formula: see text] indices) in the kinetic exchange models of market dynamics. We study the variations of [Formula: see text] and of the indices [Formula: see text] and [Formula: see text] with the saving propensity [Formula: see text] of the agents, with two different kinds of trade (kinetic exchange) dynamics. In the first case, the exchange occurs between randomly chosen pairs of agents and in the next, one of the agents in the chosen pair is the poorest of all and the other agent is randomly picked up from the rest of the population (where, in the steady state, a self-organized poverty level or SOPL appears).

Microscopic and Transcriptomic Analyses of Dalbergoid Legume Peanut Reveal a Divergent Evolution Leading to Nod-Factor-Dependent Epidermal Crack-Entry and Terminal Bacteroid Differentiation.

Root nodule symbiosis (RNS) is the pillar behind sustainable agriculture and plays a pivotal role in the environmental nitrogen cycle. Most of the genetic, molecular, and cell-biological knowledge on RNS comes from model legumes that exhibit a root-hair mode of bacterial infection, in contrast to the Dalbergoid legumes exhibiting crack-entry of rhizobia. As a step toward understanding this important group of legumes, we have combined microscopic analysis and temporal transcriptome to obtain a dynamic view of plant gene expression during (peanut) nodule development.

Rhodium-Catalyzed Directed C(sp)-H Bond Addition of 2-Arylindazoles to -Sulfonylformaldimines and Activated Aldehydes.

Rhodium-catalyzed directed C-H functionalization of 2-arylindazoles with -sulfonylformaldimines has been developed to provide a variety of -benzylarylsulfonamide derivatives with good to excellent yields. Different activated aldehydes like ethyl glyoxalate and 2,2,2-trifluoroacetaldehyde also efficiently underwent nucleophilic addition with 2-arylindazoles. These selective transformations occur through the control of C3 nucleophilicity of indazole moiety.

Fe(iii)-Catalyzed synthesis of steroidal imidazoheterocycles as potent antiproliferative agents.

An efficient and practical method has been developed for the synthesis of steroidal imidazoheterocycles via cost-effective and environmentally benign FeCl-catalyzed oxidative amination. A library of steroidal imidazo[1,2-a]pyridines was directly synthesized from readily available 2-aminopyridines and steroidal ketones in aerobic conditions. The synthesized compounds were screened for activity on human microsomal cytochrome P450s CYP7, CYP17 and CYP21.

Organophotoredox-Catalyzed Direct C-H Amination of 2-Indazoles with Amines.

A general and practical method for the direct C-H amination of 2-indazoles with a series of amines including aliphatic primary amines, secondary amines, azoles, and sulfoximines via organophotoredox-catalyzed oxidative coupling has been disclosed at room temperature under ambient air conditions. Additionally, this protocol is used for free aminated 2-indazole synthesis. A mechanistic study revealed that a single electron transfer (SET) pathway might be involved in this reaction.

Regioselective hydroarylation and arylation of maleimides with indazoles via a Rh(iii)-catalyzed C-H activation.

Switchable Rh(iii)-catalyzed highly regioselective hydroarylation and oxidative arylation of maleimides with 2-arylindazoles via C-H activation have been demonstrated. The reaction affords 3-(2-(2H-indazol-2-yl)phenyl)succinimide and 3-(2-(2H-indazol-2-yl)phenyl)maleimide derivatives in high yields with wide functional group tolerance. A mechanistic study was performed to depict C-H bond cleavage that might be involved in the turnover limiting step.

Exotic topological point and line nodes in the plaquette excitations of a frustrated Heisenberg antiferromagnet on the honeycomb lattice.

A number of topological nodes including Dirac, quadratic and three-band touching points as well as a pair of degenerate Dirac line nodes are found to emerge in the triplet plaquette excitations of the frustrated spin-1/2-antiferromagnetic Heisenberg honeycomb model when the ground state of the system lies in a spin-disordered plaquette-valence-bond-solid phase. A six-spin plaquette operator theory of this honeycomb model has been developed for this purpose by using the eigenstates of an isolated Heisenberg hexagonal plaquette. Spin-1/2 operators are thus expressed in the Fock space spanned by the plaquette operators those are obtained in terms of exact analytic form of eigenstates for a single frustrated Heisenberg hexagon.

Dioxygen-Triggered Oxo-Sulfonylation of Hydrazones.

A simple and highly efficient method for the oxo-sulfonylation of aldehyde-derived hydrazones has been developed using sulfinic acid as a source of sulfonyl group and oxygen as a green oxidant under metal-free conditions at room temperature. The present C-O and N-S bond-forming difunctionalization strategy affords diversely functionalized -acylsulfonamides in good yield. Experimental results suggest a radical mechanistic pathway of the present reaction.