Thyroglossal duct cyst carcinoma in child†.

Papillary thyroid carcinoma occurring in a thyroglossal cyst is a rare condition especially in children, and there is no consensus regarding management. There are only 10 other documented cases in the English literature for children under the age of 12. We discuss one such case.

Somatostatin analogs modulate AIP in somatotroph adenomas: the role of the ZAC1 pathway.

Context: Somatotroph adenomas harboring aryl hydrocarbon receptor interacting protein (AIP) mutations respond less well to somatostatin analogs, suggesting that the effects of somatostatin analogs may be mediated by AIP.

Objective: The objective of the investigation was to study the involvement of AIP in the mechanism of effect of somatostatin analogs.

Design: In the human study, a 16-wk somatostatin analog pretreatment compared with no pretreatment.

Molecular genetics of the aip gene in familial pituitary tumorigenesis.

Pituitary adenomas usually occur as sporadic tumors, but familial cases are now increasingly identified. As opposed to multiple endocrine neoplasia type 1 and Carney complex, in familial isolated pituitary adenoma (FIPA) syndrome no other disease is associated with the familial occurrence of pituitary adenomas. It is an autosomal dominant disease with incomplete variable penetrance.