Publications by authors named "Asigul Yimit"
Article Synopsis
- Dorset sheep are often used in cardiovascular research due to their similarities to human anatomy and physiology, particularly for studying single-ventricle physiology.
- Researchers observed unexpected changes in central venous pressure that couldn’t be explained by gravity, leading them to investigate the inferior vena cava (IVC) for potential narrowing or compression.
- The study found significant differences in IVC dimensions and pressures based on body position, revealing more smooth muscle in the abdominal portion of the IVC compared to the thoracic part, which enhances understanding of sheep physiology and informs future research methods.
Article Synopsis
- - Tissue engineering is advancing the creation of artificial human cardiac muscle patches (hCMPs) to help treat Myocardial infarction (MI) by enhancing heart regeneration.
- - Challenges such as low engraftment rates, scalability issues for clinical use, and the need for a functional vascular system hinder hCMP's practical implementation.
- - The paper explores various heart cell types for hCMP production, innovative engineering methods, and the significance of cell injection/transplantation in cardiac tissue engineering.
Patients with single ventricle heart defects requires a series of staged open-heart procedures, termed Fontan palliation. However, while lifesaving, these operations are associated with significant morbidity and early mortality. The attendant complications are thought to arise in response to the abnormal hemodynamics induced by Fontan palliation, although the pathophysiology underlying these physicochemical changes in cardiovascular and other organs remain unknown.
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