Publications by authors named "Asif Hussain Akber"
Article Synopsis
- - JE (Japanese Encephalitis) is a serious mosquito-borne viral infection that has a high fatality rate and can lead to severe neurological issues in survivors, with no known cures available.
- - The JE virus genome is relatively small (10.98 kb) and includes two coding regions and 15 peptides, with genomic analysis being conducted using 29 sequences from different countries and host animals to study its evolution.
- - The study found that a specific genome sequence from Taiwan had very few genetic variations compared to sequences from India, suggesting overall genetic similarity among JE virus strains.
Myeloid leukemia 1 (MCL-1), a BCL-2 protein family member, acts as an anti-apoptotic protein by interacting with pro-apoptotic BCL-2 proteins. Its overexpression is frequently observed in numerous cancer types including breast cancer, and is closely linked to the initiation and progression of tumors as well as poor prognosis and resistance to therapeutic interventions. Here, a database of 3402 chemicals with established therapeutic activity against various diseases was chosen and systematically screened against the MCL-1 protein.
View Article and Find Full Text PDFThe majority of human tumors are characterized by abnormal signaling caused by oncogenic RAS proteins. KRAS is a member of the RAS family and is currently one of the most thoroughly researched targets for cancer treatment due to its prevalence in a variety of deadly malignancies. Targeting the KRAS protein, which plays a crucial role in regulating cell growth, differentiation, and apoptosis, shows great potential as a strategy for fighting cancer.
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