Profiling genetic mutations in the DNA damage repair genes of oral squamous cell carcinoma patients from Pakistan.

Herein, we reported mutations in five DNA Damage Repair (DDR) i.e., TP53, ATR, ATM, CHEK1 and CHEK2 involved in OSCC using NG-WES and their analysis using bioinformatics tools.

Bibliometric Analysis of Single-Atom Catalysis: A Scoping Review.

Background: Single-Atom Catalysts (SACs) are heterogeneous catalysts that demonstrate exceptional efficiency and selectivity due to the use of individual metal atoms at the atomic scale. The substantial number of patents filed on SACs underscore their commercial and technological importance, highlighting their potential across various industries. SACs are increasingly applied in areas such as energy generation, environmental applications, and chemical synthesis, reflecting their growing scientific and technical importance.

Flavonoids of Pigmented Rice Lower Blood Glucose Levels by Regulating the Glucose Metabolism Pathway and Gut Microbiota Composition.

Black and red rice have many physiological effects, including antioxidant capacity and decreasing blood glucose, because they are flavonoid-rich. Here, our study found that Hongcaomi (a red rice variety) of five examined rice cultivars contained the highest total polyphenol content and total flavonoid content and the strongest antioxidant activity, with values of 5.83 mg GAE/g, 1.

An effective encryption approach using a combination of a non-chain ring and a four-dimensional chaotic map.

Algebraic structures are highly effective in designing symmetric key cryptosystems; however, if the key space is not sufficiently large, such systems become vulnerable to brute-force attacks. To address this challenge, our research focuses on enlarging the key space in symmetric key schemes by integrating the non-chain ring with a four-dimensional chaotic system. While chaotic maps offer significant potential for data processing, relying solely on them does not fully leverage their operational advantages.

Comparative Effects of GLP-1 and GLP-2 on Beta-Cell Function, Glucose Homeostasis and Appetite Regulation.

Glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) are related intestinal L-cell derived secretory products. GLP-1 has been extensively studied in terms of its influence on metabolism, but less attention has been devoted to GLP-2 in this regard. The current study compares the effects of these proglucagon-derived peptides on pancreatic beta-cell function, as well as on glucose tolerance and appetite.

Modern contraceptive use among currently married non-pregnant women (aged 15-49 years) in West Bengal, India: a reflection from NFHS-5.

Background: There is a dearth of research on modern family planning practices in high focus states like West Bengal in India with diverse population groups and distinct health needs. Thus, this study aims to investigate the latest picture of modern contraceptive use and its associated socio-demographic factors among currently married non-pregnant of reproductive aged (15-49 years) women in West Bengal.

Methods: The study is based on secondary data, collected from the fifth round of the National Family Health Survey (NFHS-5; 2019-20).

Preserve or destroy: Orphan protein proteostasis and the heat shock response.

Most eukaryotic genes encode polypeptides that are either obligate members of hetero-stoichiometric complexes or clients of organelle-targeting pathways. Proteins in these classes can be released from the ribosome as "orphans"-newly synthesized proteins not associated with their stoichiometric binding partner(s) and/or not targeted to their destination organelle. Here we integrate recent findings suggesting that although cells selectively degrade orphan proteins under homeostatic conditions, they can preserve them in chaperone-regulated biomolecular condensates during stress.

GeSe-embedded metal-oxide double heterojunctions for facilitating self-biased and efficient NIR photodetection.

Infrared radiation detection is significantly important in communication, imaging, and sensing fields. Here, we present the integration of germanium selenide (GeSe) with a metal-oxide heterojunction to achieve efficient near-infrared (850 nm) photodetection under zero bias conditions. Nickel oxide (NiO) and silicon (Si) formed a favorable energy band alignment for the efficient separation of photogenerated charge carriers, resulting in a high figure of merits.

Hepatocellular carcinoma antibodies preferably identify nitro-oxidative-DNA lesions induced by 4-Chloro-orthophenylenediamine and DEANO.

The widespread use of oxidative hair colouring cosmetics threatens public health. Phenylenediamine derivatives serve as the main pigment in permanent hair colours. They interact with biological macromolecules, altering their functional and structural physiology.

Rural-urban differentials in undernutrition among women in India: Evidence from a decomposition approach.

Global healthcare and nutrition policies have not eliminated the pressing public health issue of undernutrition, which remains a paramount public health concern in countries like India, coinciding with overweight and obesity, in the form of dual burden of malnutrition. This study delves into the rural-urban differential in undernutrition among reproductive-aged women in India for targeted policy interventions and to achieve universal health coverage. Data from the recent iteration of the National Family Health Survey (NFHS-5; 2019-21) were utilized to examine the factors influencing rural-urban differentials in women's undernutrition.

Dual-hesitant fermatean fuzzy Hamacher aggregation operators and TOPSIS with their application to multi-criteria decision-making.

The concept of the Dual-hesitant fermatean fuzzy set (DHFFS) represents a significant advancement in practical implementation, combining Fermatean fuzzy sets and Dual-hesitant sets. This new structure uses membership and non-membership hesitancy and is more adaptable for arriving at values in a domain. Since it has the capability to treat multiple fuzzy sets over the degrees of membership and non-membership, the DHFFS greatly improves the flexibility of approaches to tackle multiple-criteria decision-making (MCDM) problems.

Overexpression of Auxin/Indole-3-Acetic Acid Gene TrIAA27 Enhances Biomass, Drought, and Salt Tolerance in .

White clover ( L.) is an important forage and aesthetic plant species, but it is susceptible to drought and heat stress. The phytohormone auxin regulates several aspects of plant development and alleviates the effects of drought stress in plants, including white clover, by involving auxin/indole acetic acid (Aux/IAA) family genes.

Hemi-tongue Ischemia Due to Antiphospholipid Antibody Syndrome-A Case Report.

Antiphospholipid antibody syndrome, also known as Hughes syndrome, is a multi-system autoimmune disorder characterized by recurrent thrombosis and fetal loss. The most common types of antiphospholipid antibodies include lupus anticoagulants, anticardiolipin antibodies, and anti-beta 2 glycoprotein 1 antibodies. Owing to the prothrombotic nature of this disease, diagnosing and treating the condition as early as possible is necessary.

Feedback control of the heat shock response by spatiotemporal regulation of Hsp70.

Cells maintain homeostasis via dynamic regulation of stress response pathways. Stress pathways transiently induce response regulons via negative feedback loops, but the extent to which individual genes provide feedback has not been comprehensively measured for any pathway. Here, we disrupted the induction of each gene in the Saccharomyces cerevisiae heat shock response (HSR) and quantified cell growth and HSR dynamics following heat shock.

Circle of Vieussens: Its Importance in the Presence of Significant Coronary Artery Stenosis in a 26-Year-Old Female With Kawasaki Disease.

In patients with coronary artery disease (CAD), collateral circulation aids in sustaining myocardial perfusion and cardiac function. The circle of Vieussens is a rare collateral pathway between the right coronary artery and the left anterior descending artery (LAD) that plays a significant role specifically in patients with chronic total occlusions (CTOs). This article presents a unique case of the circle of Vieussens in a 26-year-old Asian female with a history of Kawasaki disease and CTO of the proximal LAD.

Triple gene mutations boost amylose and resistant starch content in rice: insights from //OE- mutants.

Previous studies have modified rice's resistant starch (RS) content by mutating single and double genes. These mutations include knocking out or reducing the expression of or genes, as well as overexpressing . However, the impact of triple mutant //OE- on RS contents remained unknown.

Unlocking fertility in the female gametophyte: a DEAD-box RNA helicase is essential for embryo sac development and seed setting.

This article comments on: 2024. OsRH52A, a DEAD-box protein, regulates functional megaspore specification and is required for embryo sac development in rice. Journal of Experimental Botany , 4802–4821.

Harnessing miRNA156: A molecular Toolkit for reshaping plant development and achieving ideal architecture.

Achieving ideal plant architecture is of utmost importance for plant improvement to meet the demands of ever-increasing population. The wish list of ideal plant architecture traits varies with respect to its utilization and environmental conditions. Late seed development in woody plants poses difficulties for their propagation, and an increase in regeneration capacity can overcome this problem.

Mal De Debarquement Syndrome: An Often Unrecognized and Unreported Condition.

Mal de debarquement syndrome (MdDS), also known as "the sickness of disembarkment," is characterized by a persistent bobbing, rocking, or swaying sensation reported by patients long after they have completed travel on a boat or other forms of extended transportation. A detailed patient history, focusing on specific inquiries about recent boat or ship travel, is crucial for a timely diagnosis. The syndrome is unique in that reintroducing similar movements, such as driving, swinging, or returning to the boat, alleviates symptoms temporarily.

Sustainable Cathodic Performances of VS in Rechargeable Magnesium Batteries by Cobalt Substitution.

Vanadium tetrasulfide (VS) is one of the most promising cathodic materials for rechargeable magnesium battery systems (RMBSs). Elemental substitution to expand layers, creation of sulfur vacancies, and reduction of particle sizes of VS are undoubtedly effective strategies to enhance cathodic performances. Experimental and DFT analysis revealed that valence states of vanadium and cobalt have been elevated from V to V and Co to Co in VS and that the Co-S bond length shortened due to cobalt substitution, which resulted in enhanced overall internal polarization in the layered atomic structure of VS by increasing cobalt concentrations.

Mental Health Applications of Generative AI and Large Language Modeling in the United States.

(1) Background: Artificial intelligence (AI) has flourished in recent years. More specifically, generative AI has had broad applications in many disciplines. While mental illness is on the rise, AI has proven valuable in aiding the diagnosis and treatment of mental disorders.

Brief Review and Primer of Key Terminology for Artificial Intelligence and Machine Learning in Hypertension.

Recent breakthroughs in artificial intelligence (AI) have caught the attention of many fields, including health care. The vision for AI is that a computer model can process information and provide output that is indistinguishable from that of a human and, in specific repetitive tasks, outperform a human's capability. The 2 critical underlying technologies in AI are used for supervised and unsupervised machine learning.

Neuroprotective Effects of Cannabispirenone A against NMDA-Induced Excitotoxicity in Differentiated N2a Cells.

The endocannabinoid system is found throughout the central nervous system, and its cannabinoids receptor 1 is critical in preventing neurotoxicity caused by N-methyl-D-aspartate receptor activation (NMDARs). The activity of NMDARs places demands on endogenous cannabinoids to regulate their calcium currents. Endocannabinoids keep NMDAR activity within safe limits, protecting neural cells from excitotoxicity.