Doubly Base-Stabilized Diborane(4) and Borato-Boronium Species and Their Chemistry with Chalcogens.

In an effort to isolate diborane(4) derivatives, we have developed an efficient and uncatalyzed approach using [BH·THF] and the mercaptopyridine ligand. Thermolysis of 2-mercaptopyridine, in the presence of [BH·THF], afforded a doubly base-stabilized diborane(4) species , [HB(μ-CHNS)], along with the formation of its isomeric species , [HB(μ-CHNS)], albeit in less yield. Based on the coordination of the boron with the mercaptopyridine ligand in and its spectroscopic data, compound has been designated as a borato-boronium species, in which the anionic borate and cationic boronium units are covalently bonded to each other.

Advancements in the Management of Endocrine System Disorders and Arrhythmias: A Comprehensive Narrative Review.

In recent years, notable advancements have been made in managing endocrine system disorders and arrhythmias. These advancements have brought about significant changes in healthcare providers' approach towards these complex medical conditions. Endocrine system disorders encompass a diverse range of conditions, including but not limited to diabetes mellitus, thyroid dysfunction, and adrenal disorders.

Combination of enzymatically hydrolyzed potato powder with skimmed milk powder on the quality improvements of yogurt during refrigeration storage.

Unlabelled: This study aimed to prepare a stirred type of fat-free yogurt from enzymatically hydrolyzed potato powder (EHPP) and skimmed milk powder (SMP) without changing its quality and consumer acceptance. The yogurt formulations prepared contained different amount of EHPP 0, 10, 25 and 50% and were stored for 28 days at 4 °C and observed that with increasing substitution ratio, acid production was increased while the viability of lactic acid bacteria was decreased after 28 days of storage at 4 °C. The antioxidant activities (2-Diphenyl-1-picryl-hydrazyl (DPPH) free radical scavenging activity and ferric reducing antioxidant power (FRAP) of the yogurt were increased with increasing EHPP over the storage period.

Recent Innovations in Non-dairy Prebiotics and Probiotics: Physiological Potential, Applications, and Characterization.

Non-dairy sources of prebiotics and probiotics impart various physiological functions in the prevention and management of chronic metabolic disorders, therefore nutraceuticals emerged as a potential industry. Extraction of prebiotics from non-dairy sources is economical and easily implemented. Waste products during food processing, including fruit peels and fruit skins, can be utilized as a promising source of prebiotics and considered "Generally Recognized As Safe" for human consumption.

Cooperative B-H bond activation: dual site borane activation by redox active κ-,-chelated complexes.

Cooperative dual site activation of boranes by redox-active 1,3-,-chelated ruthenium species, -[PR{κ-,-(L)}Ru{κ--(L)}], (-2a: R = Cy, -2b: R = Ph; L = NCHS), generated from the aerial oxidation of borate complexes, [PR{κ-,-(L)}Ru{κ-,,'-BH(L)}] (--1a: R = Cy, --1b: R = Ph; L = NCHS), has been investigated. Utilizing the rich electronic behaviour of these 1,3-,-chelated ruthenium species, we have established that a combination of redox-active ligands and metal-ligand cooperativity has a big influence on the multisite borane activation. For example, treatment of -2a-b with BH·THF led to the isolation of -[PRRu{κ-,,'-(NHBSBHN)(SCH)}] (-3a: R = Cy and -3b: R = Ph) that captured boranes at both sites of the κ-,-chelated ruthenacycles.

Discovery of stylissatin A analogs exhibiting potent nitric oxide inhibition.

The cyclic peptide stylissatin A(STA) was obtained from the Papua New Guinean marine spongeStylissamassaas a potent nitric oxide (NO) inhibitor.Among its reported analogs,cyclo-{Glu, Ala}-STA1potentlyinhibited theinterleukin-2 and proliferation of T-cells indicating position 2 of sequence playing important part in biological activities of this compound.In current studies, second generation analogs of STAwere synthesizedaround its most active analog1by screening position 2 of analog1with different amino acid.

Quadratus lumborum or transversus abdominis plane block for postoperative analgesia after cesarean: a double-blinded randomized trial.

Background: Multimodal analgesia (MMA) is the current standard practice to provide post-cesarean analgesia. The aim of this study was to compare the analgesic efficacy of quadratus lumborum (QL) block and transversus abdominis plane (TAP) block as an adjunct to MMA.

Methods: Eighty mothers undergoing cesarean delivery under spinal anesthesia were randomized to receive either TAP or transmuscular QL block (QLB) with 20 mL 0.

Efficacy of transmuscular quadratus lumborum block in the multimodal regimen for postoperative analgesia after total laparoscopic hysterectomy: A prospective randomised double-blinded study.

Background And Aims: Transmuscular Quadratus Lumborum Block (TQLB) is a novel regional anaesthesia technique, however, its analgesic efficacy as a component of multimodal analgesia (MMA) in Total Laparoscopic Hysterectomy (TLH) is not well studied. The aim of the study was to evaluate the analgesic efficacy of TQLB as a component of MMA for postoperative pain in TLH.

Methods: A prospective double-blind randomised controlled study was done after approval from the ethical committee and informed patient consent.

Cooperative B-H and Si-H Bond Activations by κ-,-Chelated Ruthenium Borate Complexes.

Cooperative E-H (E = B, Si) bond activations employing κ--chelated ruthenium borate species, [PPh{κ--(NSCH)}Ru{κ--HB(NCHS)}], () are established. Treatment of with BH·SMe yielded the six-membered ruthenaheterocycle [PPh{κ--(BHNSCH)}Ru{κ--HB(CHNS)}] () formed by a hemilabile ring opening of a Ru-N bond and capturing of a BH unit coordinated in an "end-on" fashion. On the other hand, the bulky borane HBMes shows different reactivity with that led to the formation of the two dihydroborate complexes [{κ--(NBHMes)(SCH)}Ru{κ--HB(CHNS)}] () and [PPh{κ--(NBHMes)(SCH)}Ru(κ--CHNS)] (), in which HBMes has been inserted into the Ru-N bond of the initial κ--chelated ligand.

Isolation and antimicrobial susceptibility testing of Helicobacter pylori strains from gastric biopsies from Pakistani patients.

Helicobacter pylori is the etiological agent of gastritis and peptic ulcer. This importance had proposed antibiotics as a principle treatment of gastrointestinal pathologies. The focus of this research was to investigate the occurrence of H.

Five-Membered Ruthenacycles: Ligand-Assisted Alkyne Insertion into 1,3-N,S-Chelated Ruthenium Borate Species.

Building upon previous work, the chemistry of [(η -p-cymene)Ru{P(OMe) OR}Cl ], (R=H or Me) has been extended with [H B(mbz) ] (mbz=2-mercaptobenzothiazolyl) using different Ru precursors and borate ligands. As a result, a series of 1,3-N,S-chelated ruthenium borate complexes, for example, [(κ -N,S-L)PR Ru{κ -H,S,S'-H B(L) }], (2 a-d and 2 a'-d'; R=Ph, Cy, OMe or OPh and L=C H NS or C H NS ) and [Ru{κ -H,S,S'-H B(L) } ], (3: L=C H NS, 3': L=C H NS ) were isolated upon treatment of [(η -p-cymene)RuCl PR ], 1 a-d (R=Ph, Cy, OMe or OPh) with [H B(mp) ] or [H B(mbz) ] ligands (mp=2-mercaptopyridyl). All the Ru borate complexes, 2 a-d and 2 a'-d' are stabilized by phosphine/phosphite and hemilabile N,S-chelating ligands.

Linum usitatissimum L. seeds: Flax gum extraction, physicochemical and functional characterization.

Flax gum (FG) was extracted and purified from flaxseed (Linum usitatissimum L.) locally called as Alsi. Physicochemical and functional aspects of separated gum were interrogated in detail.

Assessing and Reporting Household Chemicals as a Novel Tool to Mitigate Pesticide Residues in Spinach (Spinacia oleracea).

Non-selective use of pesticide to increase productivity leaves residues on crops. These pesticides after consumption have a detrimental effect on human health and their intake can lead to various diseases such as kidney damage, neurological disorders, cardiovascular diseases, circulatory and reproductive problems. The recent study was designed to assess the effects of household processing treatments such as acidic solutions (acidic acid and citric acid), alkaline solutions (sodium chloride and sodium carbonate) and biological solutions (radish, ginger, garlic, and lemon extracts) were evaluated for their efficiency for removal of pesticides in spinach by gas chromatography with electron capture detector (GC-ECD).

Optimization of mixed surfactants-based β-carotene nanoemulsions using response surface methodology: An ultrasonic homogenization approach.

In the present study, food grade mixed surfactant-based β-carotene nanoemulsions were prepared without using any co-surfactant. Response surface methodology (RSM) along with central composite design (CCD) was used to investigate the effect of independent variables (surfactant concentration, ultrasonic homogenization time and oil content) on response variables. RSM analysis results revealed that experimental results were best fitted into a quadratic polynomial model with regression coefficient values of more than 0.

Correlation Filters for Detection of Cellular Nuclei in Histopathology Images.

Unlabelled: Nuclei detection in histology images is an essential part of computer aided diagnosis of cancers and tumors. It is a challenging task due to diverse and complicated structures of cells. In this work, we present an automated technique for detection of cellular nuclei in hematoxylin and eosin stained histopathology images.

Optimization of olive oil based O/W nanoemulsions prepared through ultrasonic homogenization: A response surface methodology approach.

The present study was conducted to prepare co-surfactant free, olive-oil based alpha tocopherol nanoemulsions, using a food grade non-ionic surfactant. Response surface methodology (RSM) was used to determine the effects of independent variables (ultrasonic homogenization time, olive oil concentrations and surfactant contents) on different physico-chemical characteristics of O/W nanoemulsions. This study was carried out using a central composite design.

Cardio-protective and anti-cancer therapeutic potential of Nigella sativa.

Nigella sativa is the miraculous plant having a lot of nutritional and medicinal benefits, and attracts large number of nutrition and pharmacological researchers. N. sativa seed composition shows that it is the blessing of nature and it contains and many bioactive compounds like thymoquinone, α-hederin, alkaloids, flavonoids, antioxidants, fatty acids many other compounds that have positive effects on curing of different diseases.

A question mark on iron deficiency in 185 million people of Pakistan: its outcomes and prevention.

Micronutrient deficiency especially the iron deficiency is the bane of our lives, affecting all strata of society. Unfortunately, the women during pregnancy, adolescence, and children are under this curse particularly in developing countries like Pakistan. It is one of the biggest reasons of complications during pregnancy and malnourished children under five years of age.

Physicochemical characteristics, nutritional properties, and health benefits of argan oil: a review.

The argan tree (Argania spinosa L. Skeels), an endemic tree in Morocco, is the most remarkable species in North Africa, due to its botanical and bioecologic interest as well as its social value. Argan oil is traditionally well known for its cardioprotective properties and it is also used in the treatment of skin infections.

Achieving the Meaningful Use Standard: A Model for Implementing Change Within Medical Practices.

Purpose: Change management in medical practices is often an uphill battle. Lack of agreement on standards, ineffective leadership, inertia, inconsistent access to data, and inability to clearly define and communicate the benefits of change represent significant barriers to success. In 2009, the Health Information Technology for Economic and Clinical Health (HITECH) Act created the meaningful use (MU) incentive program administered through the Centers for Medicare and Medicaid Services (CMS).

Lactobacillus acidophilus: characterization of the species and application in food production.

L. acidophilus is a homofermentative, microaerophilic, short chain gram positive microorganism with rod morphology having its bacteriocins belonging to class II a. Several bacteriocins of L.

A question mark on zinc deficiency in 185 million people in Pakistan--possible way out.

This paper reviews research published in recent years concerning the effects of zinc deficiency, its consequences, and possible solutions. Zinc is an essential trace element necessary for over 300 zinc metalloenzymes and required for normal nucleic acid, protein, and membrane metabolism. Zinc deficiency is one of the ten biggest factors contributing to burden of disease in developing countries.

Stabilizers: indispensable substances in dairy products of high rheology.

The functionality of stabilizers is apparent in many food applications including dairy products. The role of stabilizers like gelatin, pectins, alginates, carboxymethylcellulose, gums, ispghol, sago starch, and chitosan in the development of dairy products of high rheology, like yoghurt, ice cream, and flavored milk, is discussed in this review. Attention is also paid to comprehend on interactions among milk proteins, minerals, and other milk constituents with the reactive sites of stabilizers to get the desirable properties such as appearance, body and texture, mouthfeel, consistency.

Nutritional and health perspectives of beans (Phaseolus vulgaris L.): an overview.

Beans, the variants of Phaseolus vulagris, are nutritionally and economically important food crop in each part of the world. Besides providing nutrients such as multifaceted carbohydrates, elevated proteins, dietary fiber, minerals, and vitamins, these also contain rich variety of polyphenolic compounds with prospective health benefits. This review mainly focuses the important nutritional aspects of beans as well as their contribution in decreasing the risks of chronically degenerative diseases.

Perspective of surface active agents in baking industry: an overview.

Different researchers have previously used surfactants for improving bread qualities and revealed that these compounds result in improving the quality of dough and bread by influencing dough strength, tolerance, uniform crumb cell size, and improve slicing characteristics and gas retention. The objective of this review is to highlight the areas where surfactants are most widely used particularly in the bread industries, their role and mechanism of interaction and their contribution to the quality characteristics of the dough and bread. This review reveals some aspects of surface-active agents regarding its role physiochemical properties of dough that in turn affect the bread characteristics by improving its sensory quality and storage stability.