Surviving a Heartbreak: Penetrating Chest Stab Wounds Through Multiple Cardiac Structures.

• Cardiac injuries can present in varied ways; therefore, close monitoring is crucial. • TEE and 3D echocardiography are useful to assess complications from stab injuries. • Early identification and management of complications may improve patient outcomes.

DECOMICS, a shiny application for unsupervised cell type deconvolution and biological interpretation of bulk omic data.

Summary: Unsupervised deconvolution algorithms are often used to estimate cell composition from bulk tissue samples. However, applying cell-type deconvolution and interpreting the results remain a challenge, even more without prior training in bioinformatics. Here, we propose a tool for estimating and identifying cell type composition from bulk transcriptomes or methylomes.

Interleukin-22 Promotes Cell Proliferation to Combat Virus Infection in Human Intestinal Epithelial Cells.

Interferon lambdas (IFN-λs) are crucial to control virus infections at mucosal surfaces. Interleukin-22 (IL-22) was reported to help IFN-λ control rotavirus infection in the intestinal epithelium of mice either by aiding in the induction of interferon-stimulated genes (ISGs) or by increasing cell proliferation thereby clearing virally infected cells. We investigated whether IL-22 and IFN-λs exhibit similar synergistic effects in human intestinal epithelial cells (IECs) models.

Luminescence Thermometry Based on the Upconversion Luminescence from the Stark Sublevels of BaYF:Yb, Tm Phosphor.

Visible and near-infrared (NIR) upconversion luminescence (UCL) emissions originating from the BaYF: Yb, Tm systems were investigated under a laser excitation at 980 nm. The BaYF:20 mol% Yb, x mol% Tm and BaYF: y mol% Yb, 0.5 mol% Tm phosphors showed prominent UCL at 800 and 810 nm.

An Unusual Case of Impending Paradoxical Embolism Through a Patent Foramen Ovale in Renal Cell Carcinoma.

Impending paradoxical embolism (IPDE) is a clinical emergency with adverse outcomes. Due to its rarity, larger research cannot be obtained to provide definitive therapy alternatives. We report a case of a tumor embolus from a renal cell carcinoma (RCC) that caused a right atrial mass, pulmonary embolus, and impending paradoxical embolus via a patent foramen ovale (PFO) and its management.

Isolation and screening of sulfur-oxidizing bacteria from coast of Bhavnagar, India, and formulation of consortium for bioremediation.

Reduced sulfur compounds are a nuisance in coastal industries causing heavy economical as well as ecological loss. One such compound, hydrogen sulfide, is proven toxic to aquatic animals as it interferes with their respiration and metabolism as well as overall development, thereby causing direct increase in mortality. Typically, 96-h LC values to freshwater and marine fishes are 0-25µM and 525-700µM, respectively.

Super enhancers define regulatory subtypes and cell identity in neuroblastoma.

Half of the children diagnosed with neuroblastoma (NB) have high-risk disease, disproportionately contributing to overall childhood cancer-related deaths. In addition to recurrent gene mutations, there is increasing evidence supporting the role of epigenetic deregulation in disease pathogenesis. Yet, comprehensive cis-regulatory network descriptions from NB are lacking.

Enzymatic pretreatment of algal biomass has different optimal conditions for biogas and bioethanol routes.

Enzymatic pretreatment is emerging as an efficient tool for the extraction of biofuel precursors from algal biomass. However, yardsticks for end-use directed selection of optimal pretreatment conditions are not yet identified. The present study, for the first time, reveals different optimal conditions for algal biomass solubilization and sugar release.

Material platform for realization of a "fiber-like" lossy mode resonance response in a simple Kretschmann-Raether geometry: publisher's note.

This publisher's note contains corrections to Opt. Lett.46, 3065 (2021).

Material platform for realization of a "fiber-like" lossy mode resonance response in a simple Kretschmann-Raether geometry.

The lossy mode resonance (LMR) phenomenon is almost exclusively limited to fiber optics, since the thin film configuration yields a relatively shallow resonance dip compared to its fiber counterpart. In this Letter, we bridge this frustrating intensity gap between these basic configurations by choosing vacuum-deposited metallic indium-rich indium tin oxide as the coating material. LMR attenuation as high as -14.

The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity.

COVID-19 outbreak is the biggest threat to human health in recent history. Currently, there are over 1.5 million related deaths and 75 million people infected around the world (as of 22/12/2020).

Single-cell analyses reveal SARS-CoV-2 interference with intrinsic immune response in the human gut.

Exacerbated pro-inflammatory immune response contributes to COVID-19 pathology. However, despite the mounting evidence about SARS-CoV-2 infecting the human gut, little is known about the antiviral programs triggered in this organ. To address this gap, we performed single-cell transcriptomics of SARS-CoV-2-infected intestinal organoids.

Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma.

Neuroblastoma is a pediatric tumor of the developing sympathetic nervous system. However, the cellular origin of neuroblastoma has yet to be defined. Here we studied the single-cell transcriptomes of neuroblastomas and normal human developing adrenal glands at various stages of embryonic and fetal development.

Use of Suture Tapes Versus Conventional Sutures for Arthroscopic Rotator Cuff Repairs: A Systematic Review and Meta-analysis.

Background: Various suture materials are available for arthroscopic rotator cuff repair. More recently, suture tapes have become popular as they are perceived to be easier to use with less soft tissue irritation. However, little is known about their biomechanical and clinical properties compared with conventional sutures in rotator cuff repairs.

Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastoma.

The migrational propensity of neuroblastoma is affected by cell identity, but the mechanisms behind the divergence remain unknown. Using RNAi and time-lapse imaging, we show that ADRN-type NB cells exhibit RAC1- and kalirin-dependent nucleokinetic (NUC) migration that relies on several integral components of neuronal migration. Inhibition of NUC migration by RAC1 and kalirin-GEF1 inhibitors occurs without hampering cell proliferation and ADRN identity.

Upconversion process in BaY F :Yb ,Ho phosphor for optical thermometry.

A BaY F :Yb ,Ho phosphor was synthesized using a simple precipitation method. The temperature-sensing properties of BaY F :Yb ,Ho phosphor were investigated using the fluorescence intensity ratio (FIR) of the thermally coupled energy levels ( F and S ) of Ho . Energy transitions F → I and S → I gave rise to emission peaks at 538 nm and 549 nm, respectively.

Dorsal bridge plating versus. Transarticular screw fixation for lisfranc injuries: A systematic review and meta-analysis.

Lisfranc injuries are relatively uncommon but carry devastating consequences if left untreated. Although many surgical techniques have been proposed for best operative management, there is an ongoing debate over which procedure is superior. We performed a systematic review and meta-analysis comparing the outcomes of transarticular screw fixation and dorsal bridge plating in management of Lisfranc injuries.

Efficacy of cellulose paper treated with Cu and Ag oxide nanoparticles synthesized via pulsed laser ablation in distilled water in the annihilation of bacteria from contaminated water.

In the present work, nanoparticles of copper and silver synthesized via pulsed laser ablation of the respective targets in distilled water are applied to cellulose filter paper to check their effectiveness in the annihilation of bacteria from contaminated water. The treatment of the filter paper with the nanoparticles is found to be an excellent way to get rid of two common bacteria, Staphylococcus aureus and Escherichia coli, from contaminated water. The spread plate method on agar, employed to test the antibacterial efficacy of the nanoparticle-treated papers, clearly shows the absence of bacterial growth upon coming into contact with the nanoparticles in the filter paper.

Pelargonidin 3-glucoside-enriched strawberry attenuates symptoms of DSS-induced inflammatory bowel disease and diet-induced metabolic syndrome in rats.

Purpose: To determine whether the anthocyanin, pelargonidin 3-glucoside (P3G), attenuates symptoms of inflammatory bowel disease (IBD) and metabolic syndrome in rats.

Methods: We tested P3G-enriched strawberry in two models of chronic inflammation in rats, chronic IBD induced by 0.5% dextran sodium sulphate in the drinking water for 12 weeks (D) and metabolic syndrome induced by a high-carbohydrate, high-fat diet (H) for 16 weeks.

Are we missing 'previously treated' smear-positive pulmonary tuberculosis under programme settings in India? A cross-sectional study.

In 2007, a field observation from India reported 11% misclassification among 'new' patients registered under the revised national tuberculosis (TB) control programme. Ten years down the line, it is important to know what proportion of newly registered patients has a past history of TB treatment for at least one month (henceforth called 'misclassification'). A study was conducted among new smear-positive pulmonary TB patients registered between March 2016 and February 2017 in 18 randomly selected districts to determine the effectiveness of an active case-finding strategy in marginalised and vulnerable populations.

Role of confining liquids on the properties of Cu@CuO nanoparticles synthesized by pulsed laser ablation and a correlative ablation study of the target surface.

The effect of confining liquid on the properties of copper nanoparticles synthesized by pulsed laser ablation in two organic solvents, methanol and 2-propanol is investigated along with the effect of the laser irradiation time on the synthesized nanoparticles. To understand the role of confining liquids on the formation mechanism of the nanoparticles in different environments, the results obtained in the organic solvents are compared to those obtained in distilled water. The increase in the average size of the nanoparticles from 7-19 nm with the laser irradiation time from 15-60 minutes is accompanied by a shift in the plasmonic peak towards longer wavelength from 606-621 nm, respectively in methanol.

Anomalous kinetic roughening in growth of MoS films under pulsed laser deposition.

Growth dynamics of thin films expressed by scaling theory is a useful tool to quantify the statistical properties of the surface morphology of the thin films. To date, the growth mechanism for 2D van der Waals materials has been rarely investigated. In this work, an experimental investigation was carried out to identify the scaling behavior as well as the growth mechanism of 2D MoS thin films, grown on glass substrates by pulsed laser deposition for different deposition time durations, using atomic force microscopy images.