Publications by authors named "Ashwath Sampath"
Article Synopsis
- Cutaneous pyogenic granulomas (PGs) are benign tumors with unclear causes, but recent research indicates they may be linked to genetic changes in specific cellular pathways.
- The authors discuss three cases of spontaneous multifocal PGs that began during infancy, lacking associated vascular issues or clear causes, and show genetic mutations in the Ras/Raf/MAPK pathway.
- These PGs did not respond well to treatments like beta-blockers and mTOR inhibitors, but improved significantly with pulsed dye laser therapy; the authors suggest the term "spontaneous multifocal PGs" for this condition.
Methods for describing and reporting the clinical and histologic characteristics of cutaneous tissue samples from patients with hidradenitis suppurativa (HS) are not currently standardized, limiting clinicians' and scientists' ability to uniformly record, report, and communicate about the characteristics of tissue used in translational experiments. A recently published consensus statement outlined morphological definitions of typical HS lesions, but no consensus has been reached regarding clinical characterization and examination of HS tissue samples. In this study, we aimed to establish a protocol for reporting histopathologic and clinical characteristics of HS tissue specimens.
View Article and Find Full Text PDFBackground: Mohs surgery (MS) is the gold standard for treating nonmelanoma skin cancers in cosmetically sensitive areas.
Objective: To investigate MS costs over time when adjusting for medical inflation while considering the perspective of patients, payers, and health care systems.
Methods: A retrospective claim analysis using data from the International Business Machines MarketScan Commercial Claims and Encounters Database from 2007 through 2019 was performed.
Anifrolumab for treatment of refractory cutaneous lupus erythematosus.
Clin Exp Dermatol
November 2022
Article Synopsis
- Cutaneous lupus erythematosus (CLE) is a skin-related condition linked to systemic lupus erythematosus (SLE), requiring evolving treatment approaches for moderate to severe cases.
- Anifrolumab, a monoclonal antibody that targets the IFN-α receptor 1, has shown promise in treating patients with resistant CLE and has been approved based on positive clinical trial results.
- A case series involving three patients treated with anifrolumab for at least 12 weeks revealed significant improvements in skin symptoms and appearance, highlighting its potential as an effective treatment for those unresponsive to standard therapies.
Melanomas only account for 4% of all dermatologic cancers yet are responsible for 80% of deaths. Notably, melanomas of the hand and foot have a worse prognosis when compared with melanomas of other anatomic regions. Likely this is due to intrinsic biologic characteristics, delayed diagnosis, difficult surgical excision due to delicate anatomy, and lack of definitive diagnostic and therapeutic guidelines.
View Article and Find Full Text PDFSurgical site infections (SSIs) pose challenges to the outcome of superficial cutaneous procedures. The objective of this study was to summarize published data regarding appropriate perioperative considerations to decrease SSI, including antiseptic use, topical decolonization, antibiotic prophylaxis, and clean versus sterile technique in superficial cutaneous procedures. A literature search was performed via PubMed and Cochrane Library by using relevant keywords.
View Article and Find Full Text PDFWe report a case of an osteochondroma in a 47-year-old woman presenting with a 2-month history of thoracic back pain that radiated down her left arm. Based on imaging features, the osteochondroma was initially thought to represent a calcified meningioma. The unusual features of the case include the location of the tumor, patient age, the erosion of the vertebra, and the confusing neuroradiological features.
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