Surface Modification Strategies for Enhanced Morphological Performance in Biomedical Implantation: Recent Developments, Challenges, and Future Scope in the Health Sector.

Surface modification is the science of manipulating surface morphology and interfacial properties and also plays a vital role in biomedical implantation. A few of the interfacial properties are biocompatibility, protein adsorption, wettability, cell proliferation, collagen, etc. These properties depend on surface modification strategies and significantly impact the implant response within the host body.

Horizontal Transfer of miR-643 from Cisplatin-Resistant Cells Confers Chemoresistance to Recipient Drug-Sensitive Cells by Targeting APOL6.

Acquisition of resistance to cisplatin is a major impediment to the success of cisplatin-based combination therapies for cancer. Recent studies indicate that exosomal miRNAs derived from drug-resistant tumour cells can confer resistance properties to recipient cells by a horizontal transfer mechanism. Although the role of horizontal transfer of a few miRNAs has been described, little is known about the concerted action of horizontal transfer of miRNAs in conferring cisplatin resistance.

MicroRNA106a regulates matrix metalloprotease 9 in a sirtuin-1 dependent mechanism.

Cellular migration is important during many physiological as well as pathological conditions and is regulated very tightly by an intricate network of signaling and effector molecules. One of the important players during cellular migration are matrix metalloproteases and their levels have been reported to be important in determining the cellular migratory properties during metastasis. MMPs and regulators of MMPs therefore, present themselves as potent candidates for manipulation, to control conditions where they get dysregulated.