A Glimpse for the subsistence from pandemic SARS-CoV-2 infection.

COVID-19 is an emerging viral pandemic caused by SARS-CoV-2, which is the causative agent of unprecedented disease-causing public health threats globally. Worldwide, this outbreak is wreaking havoc due to failure in risk assessment regarding the urgency of the pandemic. As per the reports, many secondary complications which include neurological, nephrological, gastrointestinal, cardiovascular, immune, and hepatic abnormalities, are linked with COVID -19 infection which is associated with prominent respiratory disorders including pneumonia.

Funding Innovation and Risk: A Grey-Based Startup Investment Decision.

As found in behavioral decision theory, venture capitalists (VCs) rely on heuristics and bias, owing to their bounded rationality, either by limited alternatives or information and resources. India's booming startup scene challenges VCs in decision-making owing to information overload from numerous evolving ventures, which hinders informed judgment. VC investment behavior, due diligence, and cognitive factors related to decision-making have always drawn the attention of researchers.

Re-188 lipiodol in hepatocellular carcinoma with portal vein thrombosis: a pilot study using novel chelating agent N-DEDC and its comparison with (A)HDD.

Objective: Hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT) have limited therapeutic options, Re-188 lipiodol transarterial therapy being one of them. We aimed to assess the safety and efficacy of Re-188 lipiodol exclusively in HCC with PVT as well as to compare two chelating agents for the synthesis of Re-188 lipiodol: novel bis-(diethyldithiocarbamato) nitrido (N-DEDC) with existing acetylated 4-hexadecyl 1-2,9,9-tetramethyl-4,7-diaza-1,10-decanethiol [(A)HDD].

Methods: Patients with radiological diagnosis of HCC with PVT having Eastern Cooperative Oncology Group (ECOG) performance status ≤2 and Child Pugh score (PS) A or B were recruited.

Automated Myocardial Infarction Screening Using Morphology-Based Electrocardiogram Biomarkers.

Ischemic heart disease (IHD), a critical and dreadful cardiovascular disease, is a leading cause of death globally. The steady progress of IHD leads to an irreversible condition called myocardial infarction (MI). The detection of MI can be done by observing the altered electrocardiogram (ECG) characteristics.

Comparison of 99m Tc-methylenediphosphonate and 68 Ga-BPAMD PET/computed tomography imaging in bone metastasis.

Objective: Bone is considered as the third most common site of metastases, besides lung and liver. Early detection of skeletal metastases aids in better management of skeletal-related events. In the present study cold kit-based 2,2 ' ,2 '' -(10-(2-((diphosphonomethyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl) triacetic acid (BPAMD) was labeled with 68 Ga.

Morphological Event Based Signal Quality Assessment of Electrocardiogram.

ECG signals acquired from mobile devices by unskilled users are corrupted with several noises. Poor signal quality may result in an increased number of false alarms, degrading diagnostic performance, and increasing the burden on the doctors in decoding the information for further clinical intervention. So, it is necessary to assess the quality of the signals before doing any further processing.

Normal and Abnormal Classification of Electrocardiogram: A Primary Screening Tool Kit.

Cardiovascular diseases (CVDs) are one of the principal causes of death. Cardiac arrhythmia, a critical CVD, can be easily detected from an electrocardiogram (ECG) recording. Automated ECG analysis can help clinicians to identify arrhythmia and prevent untimely death.

Simulating Stenotic Conditions of the Coronary Artery in a Lumped Parameter Model of the Cardiovascular System.

Coronary flow control mechanisms maintain the average coronary blood flow (CBF) at 4% of the cardiac output (CO) in normal adults, with no prior diagnosis of coronary artery disease (CAD), under resting conditions. This paper explores a pulsatile sixth order lumped parameter (LP) model of the cardiovascular system (CVS) which utilizes the average CBF approximated from CO along with arterial blood pressure (ABP) waveform to estimate the coronary microvascular resistance using non-linear least square optimization technique. The CVS model includes a third order model of the coronary vascular bed and is shown to achieve phasic coronary flow.

Genome-wide in silico characterization and stress induced expression analysis of BcL-2 associated athanogene (BAG) family in Musa spp.

Programmed cell death (PCD) is a genetically controlled process for the selective removal of damaged cells. Though understanding about plant PCD has improved over years, the mechanisms are yet to be fully deciphered. Among the several molecular players of PCD in plants, B cell lymphoma 2 (Bcl-2)-associated athanogene (BAG) family of co-chaperones are evolutionary conserved and regulate cell death, growth and development.

Camptothecin enhances I-rituximab-induced G1-arrest and apoptosis in Burkitt lymphoma cells.

Background: Rituximab is a chimeric monoclonal antibody against CD20. It is an established immunotherapeutic agent for non-Hodgkin's lymphoma. Even though rituximab has been used in clinics for decades, only 50% of the patients respond to rituximab therapy.

Facile Synthesis of a Pt(IV) Prodrug of Cisplatin and Its Intrinsically Pt Labeled Analog: A Step Closer to Cancer Theranostic.

Background Aims And Objectives: Cisplatin is extensively used in chemotherapy for treatment of a broad range of cancers. But its undesired side reactions with biomolecules that lead to severe side effects especially on kidney and nervous system, are limiting its clinical utility. To reduce its side effects, the kinetically inert Pt(IV) prodrug was recognized as an alternative approach from satisfactory results of preliminary experiments.

Formulation and clinical translation of [Lu]Lu-trastuzumab for radioimmunotheranostics of metastatic breast cancer.

Trastuzumab (Herceptin®) is an approved immunotherapeutic agent used for the treatment of metastatic breast cancer over-expressing HER2 antigen receptors. The aim of the present work is to standardize the formulation protocol of [Lu]Lu-trastuzumab addressing various reaction parameters, evaluating the efficacy of the radiolabeled product by investigations, scaling-up the preparation for administration in patients and performing preliminary clinical studies in patients suffering from metastatic breast cancer. Trastuzumab was conjugated with a suitable bi-functional chelating agent namely, -NCS-benzyl-DOTA.

An electrochemical technique for fabrication of Mn-54 sources towards characterization of gamma counting nuclear instruments.

Long lived sealed radioactive sources are used for the energy calibration and efficiency determination of counting systems used in the nuclear sector. Using a sulphate bath, a facile electrochemical method was developed by electrodeposition of Mn on 5 mm (φ) stainless steel substrates for the preparation of Mn sources for such uses. Inactive sources prepared under suitable experimental parameters characterized by XRD revealed that manganese is deposited in oxide form.

Efficacy and safety of 177Lu-DOTMP in palliative treatment of symptomatic skeletal metastases: a prospective study.

Aims: Bone-seeking radiopharmaceutical 177Lu-DOTMP with favorable pharmacokinetics in the preclinical studies has been evaluated for its role in reducing bone pain and improving quality of life (QOL) in patients with symptomatic skeletal metastases.

Method: Patients with painful widespread skeletal metastases documented on 99mTc-MDP bone scintigraphy were intravenously administered 37 MBq/kg of 177Lu-DOTMP. Visual analogue score (VAS), analgesic score, European Cooperative Group of Oncology (ECOG) and the European Organization of Research and Treatment of Cancer QLQ-C30 of all the patients were assessed at baseline and posttherapy follow-up.

Effect of structural variation on tumor targeting efficacy of cationically charged porphyrin derivatives: Comparative in-vitro and in-vivo evaluation for possible potential in PET and PDT.

tetracationic (TMPyP) and tricationic porphyrin (TriMPyCOOHP) derivatives were synthesized, characterized and investigated for binding with DNA by Isothermal Titration Calorimetry as well as by UV-Vis spectroscopy in order to study the effect of structural variation on tumor targeting efficacy of cationically charged porphyrin derivatives. Fluorescence cell imaging studies performed in cancer cell lines corroborated the findings of aforementioned studies. Photocytotoxicity experiments in A549 cell lines revealed relatively higher light dependent cytotoxic effects exerted by TMPyP compared to TriMPyCOOHP.

A standardized polyherbal preparation POL-6 diminishes alcohol withdrawal anxiety by regulating Gabra1, Gabra2, Gabra3, Gabra4, Gabra5 gene expression of GABA receptor signaling pathway in rats.

Background: Alcohol abuse is a major problem worldwide and it affects people's health and economy. There is a relapse in alcohol intake due to alcohol withdrawal. Alcohol withdrawal anxiety-like behavior is a symptom that appears 6-24 h after the last alcohol ingestion.

Dose-dependent cell cycle arrest and apoptosis in HER2 breast cancer cells byLu-CHX-A"-DTPA-Trastuzumab.

Background: Trastuzumab is a Food and Drug Administration-approved humanized monoclonal antibody which targets the extracellular domain of human epidermal growth factor receptor 2 (HER2) receptor overexpressed on HER2-positive breast cancer cells. The combination of Lutetium-177 ( Lu) (t= 6.7 days, E497 keV (78.

Estimation of Arterial Blood Pressure Waveform from Photoplethysmogram Signal using Linear Transfer Function Approach.

The primary risk factor of hypertension, is the lack of awareness caused by the unavailability of ubiquitous blood pressure (BP) measurement. In this study, we have investigated the BP estimation using the photoplethysmogram (PPG) signal and a suitable subject-specific mathematical model. The linear transfer function (LTF) technique was used to identify the subject-specific model.

Mitigating artifacts by data driven identification & correction of rotational misalignment in gamma ray computed tomography.

Industrial Computed Tomography (ICT) is a radiation based cross sectional imaging technique that requires a sample to be manipulated precisely in a specific geometry to acquire analytically useful data. Unlike medical CT, industrial CT may require use of gamma radiation from radio-isotopes like Co, Cs etc. having higher energy radiations for penetrating through higher density and thickness of material under inspection.

Clinical evaluation of kit based Tc-99m-HYNIC-RGD2 for imaging angiogenesis in breast carcinoma patients.

Background: Radiolabeled RGD peptide can be used for noninvasive in vivo imaging of αvβ3 integrin receptors leading to early detection of tumor cells and hence improving the clinical outcomes. In the present study single vial kit based HYNIC RGD2 was radiolabeled with Tc-99m and evaluated in patients with breast carcinoma.

Methods: Radiolabeling was performed via bifunctional chelator method.

One decade of 'Bench-to-Bedside' peptide receptor radionuclide therapy with indigenous [Lu]Lu-DOTATATE obtained through 'Direct' neutron activation route: lessons learnt including practice evolution in an Indian setting.

The present treatise chronicles one decade of experience pertaining to clinical PRRT services in a large-volume tertiary cancer care centre in India delivering over 4,000 therapies, an exemplar of successful PRRT programme employing indigenous Lutetium production and resources. For the purpose of systematic discussion, we have sub-divided the communication into 3 specific parts: (a) Radiopharmaceutical aspects that describes Lutetium production through 'Direct' Neutron Activation Route and the subsequent radiolabeling procedures, (b) The specific clinical nuances and finer learning points (apart from the routine standard procedure) based upon clinical experience and how it has undergone practice evolution in our setting and (c) Dosimetry results with this indigenous product and radiation safety/health physics aspects involved in PRRT services. Initiated in 2010 at our centre, the PRRT programme is a perfect example of affordable quality health care delivery, with indigenous production of the radionuclide (Lu) in the reactor and subsequent radiolabeling of the radiopharmaceutical ([Lu]Lu-DOTATATE) at the hospital radiopharmacy unit of the centre, which enabled catering to the needs of a large number of patients of progressive, metastatic and advanced Neuroendocrine Neoplasms (NENs) and related malignancies.

Targeted Tumor Therapy with Radiolabeled DNA Intercalator: A Possibility? Preclinical Investigations with Lu-Acridine.

Objective: A DNA intercalating agent reversibly stacks between the adjacent base pairs of DNA and thus is expected to exhibit preferential localization in the tumorous lesions as tumors are associated with enhanced DNA replication. Therefore, radiolabeled DNA intercalators are supposed to have potential to be used in targeted tumor therapy. Working in this direction, an attempt was made to radiolabel 9-aminoacridine, a DNA intercalator, with Lu, one of the most useful therapeutic radionuclides, and study the potential of Lu-acridine in targeted tumor therapy.

A simple and robust method for radiochemical separation of no-carrier-added Cu produced in a research reactor for radiopharmaceutical preparation.

Copper-64 is an excellent theranostic radiometal that is gaining renewed attention of the clinical community in the recent times. In order to meet the increasing demand of this radiometal, we have demonstrated the viability of its production via Zn (n,p) Cu reaction in a nuclear reactor. A semi-automated radiochemical separation module based on selective extraction of Cu as dithizonate complex was developed.

Multifunctional Core-Shell Glyconanoparticles for Galectin-3-Targeted, Trigger-Responsive Combination Chemotherapy.

Galectin-3 (gal-3) plays a crucial role in various cellular events associated to tumor metastasis and progression. In this direction, gal-3 binding core-shell glyconanoparticles based on citrus pectin (CP) have been designed for targeted, trigger-responsive combination drug delivery. Depolymerization via periodate oxidation in heterogeneous medium yielded low-molecular weight dialdehyde oligomers (CPDA) of CP with a gal-3 binding property ( = 160.