Elexacaftor-Tezacaftor-Ivacaftor in 2 cystic fibrosis adults homozygous for M1101K with end-stage lung disease.

Elexacaftor-tezacaftor-ivacaftor (ETI) therapy is shown to improve the health of individuals with cystic fibrosis (CF) who have the F508del variant. There are studies showing benefit with ETI for select rare CF variants. Limited data exists on the use of ETI in individuals with rare CF variants, particularly in those with advanced lung disease.

Rebleeding in Variceal and Nonvariceal Gastrointestinal Bleeds in Cirrhotic Patients Using Vitamin K: The LIVER-K Study.

Background: Gastroesophageal varices are the most common cause of upper gastrointestinal bleeding (UGIB) in patients with cirrhosis. Vitamin K is commonly administered to patients presenting with UGIB and elevated international normalized ratio, despite limited evidence to support this practice.

Objectives: The primary objective was to describe the incidence of rebleeding within 30 days after vitamin K administration in patients with cirrhosis and UGIB.

Thiamine Prescribing Practices for Adult Patients Admitted to an Internal Medicine Service.

Background: Thiamine (vitamin B) is an essential cofactor responsible for the breakdown of glucose, and its deficiency is associated with Wernicke encephalopathy (WE). There is a lack of evidence from systematic studies on the optimal dosing of thiamine for WE. The primary objective was to describe the prescribing patterns for IV thiamine in adult patients admitted to a large teaching hospital.