SERCA2a directs the cardioprotective role of nano-emulsion curcumin against PM-induced cardiac injury in rats by prohibiting PERK-eIF2α pathway.

Aims: Activation of endoplasmic reticulum stress (ERS) by particulate matter 2.5 (PM) has recently been linked to an increased risk of heart problems. Although the PERK- eIF2α pathway is known to be involved in ERS, its crucial role in the pathogenesis of PM-induced cardiotoxicity remains unclear.