Isolation and structural characterization of phytoconstituents from leaves of .

Phytochemical investigation of leaves led to the isolation of three new compounds: including a glycoside of simple alcohol, namely binatoside (), 3,4-dihydroxy--methyl piperidin-2-one (), and a phenyl ethanoid glycoside, namely bignanoside C (), alongside with five known compounds; including a glycoside of simple alcohol; (2) propane-1,2-diol 1--(6--caffeoy1)--D-glucopyranoside (), phenyl ethanoids; leucosceptoside A () and plantainoside C (), and iridoids; ipolamiide () and strictoloside (). The structure of the isolated compounds was elucidated by various spectroscopic methods, including 1 D and 2 D NMR experiments, HR-ESI-MS as well as by comparison with the literature.

LC-MS-based identification of bioactive compounds and hepatoprotective and nephroprotective activities of leaves against carbon tetrachloride-induced injury in rats.

The chemical profiling of the main phytoconstituents of total ethanolic extract (TEE) and its different fractions of leaves was dereplicated using liquid chromatography-high resolution-electrospray ionisation-mass spectrometry (LC-HR-ESI-MS), revealed the presence of various classes of secondary metabolites; eight phenylethanoids, two flavonoidal glycosides and two iridoids. Moreover, the hepatoprotective and nephroprotective activities of the TEE and its different fractions were investigated in carbon tetrachloride (CCl)-intoxicated rats and were compared with those of silymarin-treated group, revealing the highest potency of the EtOAc group, followed by the aqueous one in improving the CCl-induced alterations in several biochemical parameters. Besides, EtOAc and aqueous fractions exhibited the most inhibition of CCl-induced inflammatory mediators and improving the changes in the histopathological structures of the liver and kidney.

Metabolomic profiling and biological investigation of (Silva Manso) leaves, family Bignoniaceae.

Both ethyl acetate and aqueous fractions of leaves exhibited noteworthy antioxidant and nephroprotective activities against carbon tetrachloride (CCl)-induced nephrotoxicity in rats, as evidenced by the remarkable improvements of renal serum biomarkers and histopathological features. Additionally, the ethyl acetate fraction displayed a prominent antitrypanosomal activity against ; consequently, the leaves were subjected to LC-HR-ESI-MS metabolomic profiling to discover the constituents that possibly underlie their bioactivities. Therefore, ten metabolites were characterized, mostly dominated by flavonoids.

Antifungal potential of marine natural products.

Fungal diseases represent an increasing threat to human health worldwide which in some cases might be associated with substantial morbidity and mortality. However, only few antifungal drugs are currently available for the treatment of life-threatening fungal infections. Furthermore, plant diseases caused by fungal pathogens represent a worldwide economic problem for the agriculture industry.

Officinalioside, a new lignan glucoside from Borago officinalis L.

A new lignan glucoside, officinalioside (1), was isolated from n-BuOH fraction of the aerial parts of Borago officinalis L., together with four known compounds: actinidioionoside (2), roseoside (3), crotalionoside C (4) and kaempferol 3-O-β-D-galactopyranoside (5). The structure of the new compound was established by means of spectroscopic and chemical analyses.

A new bioactive sesquiterpenoid quinone from the Mediterranean Sea marine sponge Dysidea avara.

Investigation of the marine sponge Dysidea avara, family Dysideidae, afforded a new sesquiterpene (-)-N-methylmelemeleone-A (5), in addition to four known sesquiterpenes (+)-avarol (1), (+)-avarone (2), (-)-3'-methylaminoavarone (3) and (-)-4'-methylaminoavarone (4). The structure elucidation of compound 5 was based on 1D and 2D NMR spectroscopic, and HR-MS studies, as well as by comparison with the literature. Cytotoxicity, proteinkinase inhibition, inhibition of NFkB-activity and insecticidal activity were evaluated for the isolated compounds.