Agronomic biofortification of genetically biofortified wheat genotypes with zinc, selenium, iodine, and iron under field conditions.

Inherently low concentrations of zinc (Zn), iron (Fe), iodine (I), and selenium (Se) in wheat ( L.) grains represent a major cause of micronutrient malnutrition (hidden hunger) in human populations. Genetic biofortification represents a highly useful solution to this problem.

A Case Report of Drug-Induced Acute Gastric Necrosis.

The stomach has a rich blood supply; for this reason, acute gastric necrosis is a rare clinical condition and needs a high index of suspicion, especially in those patients having no history of an eating disorder and no signs of gastric distension on radiological investigations. We report on a 23-year-old male patient who presented to the emergency department with a one-day history of severe abdominal pain and multiple episodes of vomiting. On examination, his heart rate was 110 beats per minute.

The role of Internet of Things (IoT) technology in modern cultivation for the implementation of greenhouses.

In recent years, the Internet of Things (IoT) has become one of the most familiar names creating a benchmark and scaling new heights. IoT an indeed future of the communication that has transformed the objects (things) of the real world into smarter devices. With the advent of IoT technology, this decade is witnessing a transformation from traditional agriculture approaches to the most advanced ones.

Role of Supplementation with Selenium and Myo-Inositol Versus Selenium Alone in Patients of Autoimmune Thyroiditis: A Systematic Review and Meta-Analysis.

Objective: The main objective was to assess the therapeutic efficacy of selenium alone versus a combination of myo-inositol and selenium (MI + Se) in treating patients with autoimmune thyroiditis (AIT). The study aims to determine which treatment option is more effective in restoring euthyroid state, as indicated by changes in thyroid-stimulating hormone (TSH), T3, T4, thyroid peroxidase antibodies (TPOAb), and thyroglobulin antibodies (TgAb).

Methods: Google Scholar and PubMed databases were searched for randomized controlled trials (RCTs) and observational studies that reported outcomes of combined treatment (MI + Se) in restoring a euthyroid state, specifically comparing it with selenium-only (Se-only) treatment.

Preparation and Evaluation of pH-Sensitive Chitosan/Alginate Nanohybrid Mucoadhesive Hydrogel Beads: An Effective Approach to a Gastro-Retentive Drug Delivery System.

Background: Despite extensive research over the decades, cancer therapy is still a great challenge because of the non-specific delivery of chemotherapeutic agents, which could be overcome by limiting the distribution of chemotherapeutic agents toward cancer cells.

Objective: To reduce the cytolytic effects against cancer cells, graphene oxide (GO) nanoparticles (NPs) can load anticancer medicines and genetic tools.

Methodology: During the current study, folic-acid-conjugated graphene oxide (Fa-GO) hybrid mucoadhesive chitosan (CS)-based hydrogel beads were fabricated through an "ion-gelation process", which allows for regulated medication release at malignant pH.

Allantoin regulated oxidative defense, secondary metabolism and ions homeostasis in maize ( L.) under heat stress.

Unlabelled: Understanding how maize responds to temperature stress is crucial for improving its resilience and productivity under changing climate conditions. Previous studies have shown that exogenous allantoin (ALA) regulates various physiological processes in plants under cadmium and salinity stress. The existing body of literature provides limited insight into the specific mechanisms that govern the impact of ALA on the physiological and biochemical responses of maize plants under heat stress.

Drug resistance and possible therapeutic options against influenza A virus infection over past years.

Influenza A virus infection, commonly known as the flu, has persisted in the community for centuries. Although we have yearly vaccinations to prevent seasonal flu, there remains a dire need for antiviral drugs to treat active infections. The constantly evolving genome of the influenza A virus limits the number of effective antiviral therapeutic options.

Identification of common and specific cold resistance pathways from cold tolerant and non-cold tolerant mango varieties.

Mango has frequently encountered severe climate and environmental challenges such as low temperatures, seriously affecting the sustainable development of the industry. In the study, physiological measurements showed that the activities of superoxide dismutase (SOD) and peroxidase (POD) were found to be higher in Jinhuang (JH) mango plants than those of Tainong (TN) mango plants under cold stress, indicating cold tolerant (JH) and non-cold tolerant (TN) mango varieties were firstly determined. Subsequently, transcriptomics showed 8,337 and 7,996 differentially expressed genes (DEGs) were respectively identified in JH and TN mango varieties treated at 4 °C for 36 h, while more DEGs (10,683 and 10,723) were screened when treated at 4 °C for 72 h.

Biochemical Screening, In-vitro and In-silico Characterization of Citrullus colocynthis Fruit Extracts: A Combined Experimental and Computation Study.

Background: Several medicinal plants are identified as therapeutic agents for the world's most deadly disease cancer. A member of the "Cucurbitaceae" family of medicinal plants, Citrullus colocynthis (C. colocynthis) has various pharmacological actions.

Impact of iron sulfate (FeSO) foliar application on growth, metabolites and antioxidative defense of Luffa cylindrica (Sponge gourd) under salt stress.

Salt stress is becoming a major issue for the world's environment and agriculture economy. Different iron [Fe] sources can give an environmentally friendly alternative for salt-affected soil remediation. In this study the effects of Iron sulfate on Luffa cylindrica (Sponge gourd) cultivated in normal and saline water irrigated soil were examined.

The impact of statewide educational webinars on infection prevention and control knowledge and policy updates in acute and long-term care facilities during the COVID-19 pandemic: the Nebraska experience.

A Nebraska statewide webinar series was initiated during the coronavirus disease 2019 (COVID-19) pandemic for long-term care (LTC) and acute care/outpatient (AC) facilities. An impact survey was completed by 48 of 96 AC and 109 of 429 LTC facilities. The majority reported increased regulatory awareness (AC: 65%, LTC: 54%) and updated COVID-19 (AC: 61%, LTC: 69%) and general infection prevention (AC: 61%, LTC: 60%) policies.

Nitrosamine mitigation: NDMA impurity formation and its inhibition in metformin hydrochloride tablets.

The mitigation of nitrosamine formation in drug products has been studied and approaches such as using formulations with pH modifiers and antioxidants have been shown to decrease the formation of nitrosamines. However, more studies are needed to explore the effectivness of mitigation strategies with different drug models and formulations. The primary objective of this work was to assess the role of different antioxidants and pH modifiers in tablet formulations to mitigate the formation of NDMA, prepared in-house, using metformin hydrochloride as a model drug.

Adsorption isotherms and removal of lead (II) and cadmium (II) from aqueous media using nanobiochar and rice husk.

Removal of Cd(II) and Pb(II) from aqueous solutions is a challenging task and the search for novel adsorbents is underway. This study examined the efficiency of nanobiochar (NB) and rice husk (RH) in the adsorption and removal of Cd(II) and Pb(II) from water. The effect of various physicochemical parameters such as initial pH, initial Cd and Pb concentration, adsorbent dosage, and contact time were tested.

CO capturing by self-assembled belt[14]pyridine encapsulated ionic liquid complexes: a DFT study.

In the current study, CO capturing ability of encapsulated ionic liquids (ENILs) , tetramethylammonium chloride (TMACl), 1,3-dimethylimidazolium chloride (MIMCl), and methylpyridinium hexafluorophosphate (MPHP) encapsulated in self assembled belt[14]pyridine (BP) has been studied. The results show that strong van der Waals forces are involved in capturing of CO by these encapsulated ionic liquids. Strong attractive forces arise from synergistic effect of ionic liquid (encapsulated) and atoms of belt.

Development of sustainable alkali activated composite incorporated with sugarcane bagasse ash and polyvinyl alcohol fibers.

The infrastructure boom has driven up cement demand to 30 billion tons annually. To address this and promote sustainable construction, researchers are developing solutions for carbon-neutral building practices, aiming to transform industrial waste into an eco-friendly alternative. This study aims to develop and enhance the mechanical and durability properties of alkali-activated composites (AACs) by incorporating varying amounts (5, 10, 15, and 20%) of finely ground bagasse ash (GBA) and polyvinyl alcohol (PVA) fibers.

Curriculum and program evaluation in medical education: a short systematic literature review.

Medical education is constantly evolving worldwide and facing various challenges. To cope with these, continuous and fruitful evaluation of an educational program is the need of the day. This study aims to know the purpose of evaluation, various theories related to program evaluation, and different models of curriculum and program evaluation.

Role of Xpert PCR kit in assessing MRSA colonization in medical and surgical units of a tertiary care teaching hospital.

Background And Rationale: Methicillin resistant Staphylococcus aureus (MRSA) colonization increases the risk of MRSA infection. Detecting MRSA colonization can influence postoperative outcomes and prolong hospital stay. The conventional standard culture method for detecting MRSA colonization has limitations in terms of sensitivity and turnaround time.

Decoding burst swimming performance: a scaling perspective on time-to-fatigue.

Fatigue curves quantify fish swimming performance, providing information about the time ([Formula: see text]) fish can swim against a steady flow velocity () before fatiguing. Such curves represent a key tool for many applications in ecological engineering, especially for fish pass design and management. Despite years of research, though, our current ability to model fatigue curves still lacks theoretical foundations and relies primarily on fitting empirical data, as obtained from time-consuming and costly experiments.

Management of Bacteriuria and Urinary Tract Infections in the Older Adult.

Urinary tract infection (UTI) is one of the most frequent bacterial infections diagnosed in older adults and the most common reason for antibiotic prescriptions in nursing homes. Distinguishing between asymptomatic bacteriuria and UTI in older adults can be challenging and implementing a systematic approach to diagnosis using standard toolkits or algorithms is recommended for patients residing in post-acute and long-term care settings. This article reviews the pathophysiology, microbiology, diagnostic approach, treatment, and approaches to prophylaxis in the older adult.

Development of pH-responsive Hydrogel from Copolymers of Artemisia vulgaris Seed Mucilage, Mucin, and poly(methacrylate) for Controlled Delivery of Acyclovir Sodium.

To cope with the constraints of conventional drug delivery systems, site-specific drug delivery systems are the major focus of researchers. The present research developed water-swellable, pH-responsive methacrylic acid-based hydrogel scaffolds of Artemisia vulgaris seed mucilage with mucin and loaded with acyclovir sodium as a model drug. The developed hydrogel discs are evaluated for diverse parameters.

Personalization of Intravaginal rings by droplet deposition modeling based 3D printing technology.

Intravaginal rings (IVRs) are long-acting drug device systems designed for controlled drug release in the vagina. Commercially available IVRs employ a one-size-fits-all development approach, where all patients receive the same drug in similar doses and frequencies, allowing no space for dosage individualization for specific patients' needs. To allow flexibility for dosage individualization, this study explores the impact of infill-density on critical characteristics of personalized IVRs, manufactured using droplet deposition modeling three-dimensional (3D) printing technology.