Investigation of Andrographolide Effect on Non-Infected Red Blood Cells Using the H-NMR-Based Metabolomics Approach.

Andrographolide (AG) has been shown to have several medicinal and pharmaceutical effects, such as antimicrobial, anti-inflammatory, antioxidant, anti-diabetic, and anti-malarial activities. Moreover, studies to assess the pharmacological effect of AG on the metabolic changes of uninfected red blood cells (uRBCs) have not yet been investigated. This study aims to evaluate the pharmacological effects of AG compared to chloroquine (CQ) on the metabolic variations of uRBCs in vitro using a proton nuclear magnetic resonance (H-NMR)-based metabolomics approach coupled with multivariate data analysis (MVDA).

Molecular Detection and Genetic Diversity of Oocysts in Cat Faeces from Klang Valley, Malaysia, Using B1 and REP Genes in 2018.

The major route for () infection is through the ingestion of foods contaminated with oocyst from cat faeces. The microscopic detection of oocysts in cat faeces is challenging, which contributes to the failure of detecting or differentiating it from other related coccidian parasites. This study aims to detect oocysts in cat faeces using two multicopy-target PCR assays and to evaluate their genetic diversity.

A Review on the Prevalence of in Humans and Animals Reported in Malaysia from 2008-2018.

Toxoplasmosis is a disease caused by the protozoan parasite (). Human toxoplasmosis seroprevalence in Malaysia has increased since it was first reported in 1973 as shown in previous reviews of 1991 and 2007. However, over a decade since the last review, comprehensive data on toxoplasmosis in Malaysia is lacking.