Publications by authors named "Ashraf A El-Shehawy"
Article Synopsis
- Vanillin-loaded hydrogel membranes made from PVA, chitosan, and itaconic acid were created through a freezing-thawing cycle method, confirming polymer chain entanglements.
- The study explored various physicochemical properties such as swelling ratio, mechanical characteristics, gel fraction percentage, hydrolytic degradation, and thermal stability, revealing that higher chitosan and itaconic acid content improved swelling and mechanical features but decreased gel fraction.
- Tests for cell viability and antimicrobial activity demonstrated that the hydrogels effectively supported cell survival and showed potential for use as antibacterial dressings or materials in wound healing.
Article Synopsis
- Traditional herbal medicine, particularly Thymoquinone (TQ) from black seed and Piperine (PIP) from black pepper, shows promise in enhancing the effects of the cancer drug sorafenib (SOR) against triple-negative breast and liver cancer cells.
- The study utilized various methods like MTT assays and flow cytometry to analyze the cytotoxicity and the mechanisms of action, including effects on DNA methylation and histone acetylation.
- Results indicated that TQ and PIP combined with SOR led to increased cancer cell death and growth inhibition by downregulating certain oncogenic proteins and upregulating tumor suppressor miRNA-29c, while molecular docking studies confirmed strong interactions among these compounds.
Three homopolymers were successfully synthesized by direct CH-CH arylation polymerization of thieno[3,4-]pyrrole-4,6-dione or pyromellitic diimide derivatives affording highly purified polymers with high molecular weights (43.0-174.7 K).
View Article and Find Full Text PDFA convenient method for the synthesis of 2-(beta-D-glycopyranosylthio) pyridines.
Nucleosides Nucleotides Nucleic Acids
September 2003
Treatment of piperidinium salts of dihydropyridinethiolates 3 with glycosyl bromides 4 in dry acetone provides a convenient and high yielding synthesis of 1,4-dihydro-3-cyanopyridine thioglycosides 5. The structures of 5 were confirmed by oxidation as well as by 1H NMR and 13C NMR spectral analysis.
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