Lipoic acid improves wound healing through its immunomodulatory and anti-inflammatory effects in a diabetic mouse model.

Objectives: Diabetes mellitus is a chronic disease that has become more prevalent worldwide because of lifestyle changes. It leads to serious complications, including increased atherosclerosis, protein glycosylation, endothelial dysfunction, and vascular denervation. These complications impair neovascularization and wound healing, resulting in delayed recovery from injuries and an elevated risk of infections.

Epilepsy Arabic renaming to cerebroelectric disorder could minimize the stigma.

Background: Naming is an important part of human communication. The precision of medical terms greatly influences the patients and their caregivers. "Alsara'الصرع " is the Arabic term defining epilepsy.

Repurposing Dapagliflozin for Mitigation of the Kidney Injury Triggered by Cadmium in Rats: Role of Autophagy, Apoptosis, and the SIRT1/Nrf2/HO-1 Pathway.

The antioxidant/antiapoptotic features of dapagliflozin (DPG) have mediated its beneficial actions against several experimental models. However, no studies have been conducted to determine whether DPG mitigates the renal injury triggered by cadmium (Cd). Herein, DPG was studied for its potential to attenuate kidney damage in Cd-intoxicated rats, as well as to unravel the mechanisms involving oxidative events, autophagy, and apoptosis.

The Outcome of the Use of Continuous Action Compression Device for the First Metatarsophalangeal Joint Fusion.

Introduction: First metatarsophalangeal (MTP) joint fusion is a widely accepted surgical intervention for treating severe arthritis, deformities, and instability of the first MTP joint. This paper provides a review of a single surgeon's experience with continuous compression implants (CCI), which offer a notable advantage by providing uniform compression across a larger surface area of the fusion site compared to plate and screw constructs. This design potentially reduces soft tissue irritation and, consequently, the need for subsequent implant removal.

Highly Sensitive and Selective Detection of Hg ions and Antibacterial Activity Using a Schiff-base Derivative.

A simple and highly effective Schiff-base fluorescent chemosensor (S1) was synthesized and characterized by HNMR and fluorescence spectroscopy. The synthesized chemosensor was applied for the selective and sensitive detection of Hg ions. The chemosensor exhibited a strong 'turn-on' fluorescence response in a CHOH/HO (1:9, v/v) solution due to complex formation (S1-Hg) which block photo induce electron transfer (PET).

Crosstalk Between Oxidative Stress and Epigenetics: Unveiling New Biomarkers in Human Infertility.

The correlation between epigenetic alterations and the pathophysiology of human infertility is progressively being elucidated with the discovery of an increasing number of target genes that exhibit altered expression patterns linked to reproductive abnormalities. Several genes and molecules are emerging as important for the future management of human infertility. In men, microRNAs (miRNAs) like miR-34c, miR-34b, and miR-122 regulate apoptosis, sperm production, and germ cell survival, while other factors, such as miR-449 and sirtuin 1 (SIRT1), influence testicular health, oxidative stress, and mitochondrial function.

Ramp Lesions with ACL Injuries Between MRI and Arthroscopic Evaluation.

Objective: To compare the accuracy of arthroscopy with MRI in diagnosing ramp lesions associated with anterior cruciate ligament (ACL) injuries.

Design: Prospective observational study. Material and We included 100 patients with complete ACL tear.

Demographic Differences in Insomnia and Anxiety and the Association with Cardiovascular Risk Factors among Jordanian Healthy Adult.

Background: Prior studies showed that anxiety and insomnia are both associated with Cardiovascular Disease (CVD). There is a lack of literature related to the prevalence of insomnia and anxiety among healthy adult populations in developing countries as in Jordan, Therefore, this study aimed to examine the association between the CVD risk factors and both insomnia and anxiety among healthy adults had one or more modifiable CVD risk factors.

Materials And Methods: A cross-sectional method was used to examine the prevalence of anxiety, insomnia, and demographical and clinical association with anxiety and insomnia among 1000 Jordanian adult participants using the Hamilton Anxiety Rating Scale and the insomnia severity index.

Isolation of holostane-type saponins from the black sea cucumber and evaluating their anti-allergic activity: in vitro and in silico study.

Unlabelled: Sea cucumbers are both versatile marine organisms and an Asian marine food known to have several medicinal effects. We evaluated the anti-allergic potential of some major purified holostane-type saponins from the body wall of the black sea cucumber, . Six saponin compounds were isolated, holothurin B (), holothurin A (), 24-dehydro echinoside A (), desholothurin A1 (), desholothurin A (), and des 24-dehydro echinoside A ().

Diabetes knowledge, health literacy and diabetes self-care among older adults living with diabetes in Alexandria, Egypt.

Background: Type 2 diabetes is a rising health problem, especially in older adults. Health literacy and the degree of diabetes knowledge are among the factors that may influence diabetes self-care activities. The aim of this study was to assess factors affecting self-care activities among older adults living with type 2 diabetes in Alexandria, Egypt.

Microneedles integrated with atorvastatin-loaded pumpkisomes for breast cancer therapy: A localized delivery approach.

Breast cancer is the most common invasive cancer in women worldwide, having a significant impact on women's well-being. Early diagnosis of breast cancer followed by appropriate treatment is considered the best survival factor. Microneedles (MN) have been utilized for non-invasive localized breast cancer treatment.

Exploring the interplay of natural products and long non-coding RNAs in colorectal cancer: pathogenesis, diagnosis, and overcoming drug resistance.

Colorectal cancer (CRC) is recognized as one of the most prevalent malignancies, both in terms of incidence and mortality rates. Current research into CRC has shed light on the molecular mechanisms driving its development. Several factors, including lifestyle, environmental influences, genetics, and diet, play significant roles in its pathogenesis.

The effect of two preparation designs on the fracture resistance and marginal adaptation of two types of ceramic crowns using CAD/CAM technology (In vitro study).

Background: Recently, prosthodontic approaches involve more conservative procedures that include less invasive finish line preparations that use less ceramic thickness.

Aim Of The Study: This in vitro study aimed to evaluate the effect of vertical preparation and modified vertical preparation designs on the marginal adaptation and fracture resistance of two types of ceramic crowns using CAD/CAM technology.

Materials And Methods: Two typodont maxillary first premolars were embedded in acrylic resin.

Arthroscopic Assessment of the Incidence of Biceps Pulley Lesions Associated With Rotator Cuff Tears: An Observational Study.

The shoulder joint houses a stabilizing structure called the biceps pulley. Biceps pulley lesions can trigger anterior shoulder pain and frequently coincide with rotator cuff tears, whose prevalence rises with age. In our study, we aim to assess the incidence of biceps pulley lesions associated with rotator cuff tears in patients undergoing arthroscopic repair, the possible associated factors, and whether MRI findings were correlated with them.

Examining the influence of anxiety and depression on medication adherence among patients diagnosed with acute myocardial infarction.

Background: Effective medication adherence is vital for managing acute myocardial infarction (AMI) and enhancing patient well-being. This study aimed to evaluate medication adherence levels and associated factors among AMI patients using standardized assessment tools.

Methods: Employing a cross-sectional descriptive design, the study involved 210 patients diagnosed with acute myocardial infarction.

Effect of a digital two-dimensional animation program on attitude toward walking aids, performance, and fall avoidance behaviors among older adults in assisted living facilities.

The study investigated the impact of a two-dimensional animation program on attitudes towards walking aids, performance, and fall avoidance behaviors among older adults in assisted living facilities. A quasi-experimental pretest-posttest control group study was conducted on 128 older adults aged 60 years and above. The intervention group showed more favorable attitudes towards walking aids, improved cane and walker use, and reduced fall concerns.

The role of the community pharmacy work system in the enactment of pharmacists' non-technical skills.

Non-technical skills are recognised as important in various work domains, but have been the subject of debate regarding their role in ergonomics/human factors, given their focus on human behaviour itself rather than the interaction between people and systems. This study aimed to examine the relationship between non-technical skills and the work system in which they are enacted. The study setting was community pharmacies in England.

Treatment Outcomes in Vertical Shear Pelvic Fractures: A Comparative Study.

Background Vertical shear (VS) pelvic ring injuries present a unique challenge due to their inherent vertical and rotational instability and the risk of massive bleeding. VS injuries may result from either bony or ligamentous injury. The goal in the treatment of VS fractures of the pelvis is to achieve and maintain an accurate reduction of the displaced hemipelvis.

Crossover effect of knee and ankle joint training on knee mechanics after ACL reconstruction: A randomized controlled trial.

Background: Anterior cruciate ligament (ACL) rehabilitation is a common intervention after ACL reconstruction. Since different types of exercise can influence muscle and kinematic parameters in diverse ways, the training order between the knee and ankle joints may also change gait parameters.

Purpose: This study aimed to investigate whether the training sequence of the knee and ankle joints (knee followed by ankle training or vice-versa) in an ACL reconstruction (ACLR) rehabilitation program has any effects on knee extension and flexion torques.

The peels of sacred Lotus (Nelumbo nucifera) rhizomes suppress allergic reactions by inhibiting the A23187-induced degranulation in rat basophilic leukemia (RBL2H3) cells.

We isolated ten compounds from methanolic extract of the peels of sacred lotus (Nelumbo nucifera) rhizomes which were identified as β-sitosterol linoleate 1, β-sitosterol 2, lupeol 3, stigmasterol 3-O-β-D-glucoside 4, oleanolic acid 5, betulinic acid 6, pinoresinol 7, 4-hydroxybenzoic acid 8, catechin 9 and gallocatechin 10. All of the isolated compounds from the peels of sacred lotus rhizomes are reported for the first time, and were investigated for their anti-allergic activity. We found that three of them, stigmasterol 3-O-β-D-glucoside 4, oleanolic acid 5 and pinoresinol 7, were capable of inhibiting A23187-induced degranulation in RBL-2H3 cells with IC values 0.

The role of miR-765 in human cancers.

MicroRNAs, a collection of short noncoding RNAs, are promising biomarkers for identifying cancer in its early stages and tracking the effectiveness of treatment. This is due to their critical role in regulating gene expression and other vital biological functions via cell-level epigenetic mechanisms. This review brings together data on the molecular and clinical effects of miR-765 on different types of cancer.