Publications by authors named "Ashok Kumar Singh"

Article Synopsis
  • Non-tobacco products (NTP) are gaining popularity as alternatives to traditional tobacco, but there's growing concern about their potential health risks, particularly regarding oral, esophageal, and pharyngeal cancers.
  • A systematic review analyzed 49 studies involving over 132,000 participants, showing a significant increase in cancer risk associated with NTP use, with odds ratios indicating a 5x risk for oral cancer and 3x for esophageal cancer.
  • The review emphasizes the need for greater regulation and awareness, as NTP use accounts for a considerable proportion of cancer cases, urging the inclusion of NTP data in national health surveys to better address the issues in high-risk groups.
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Direct-seeded rice (DSR) is gaining popularity among farmers due to its environmentally safe and resource-efficient production system. However, managing the rice root-knot nematode (RRKN), , remains a major challenge in DSR cultivation. Developing genetic resistance is a pragmatic and effective approach compared to using hazardous pesticides.

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Article Synopsis
  • * Targeting PIM kinases for cancer treatment is promising due to their short lifespan in cells, which may lead to fewer side effects, and new strategies involve developing small molecules and PROTACs to degrade these proteins rather than just inhibiting them.
  • * The review highlights the importance of understanding the unique structure and function of PIM kinases, along with insights into new therapeutic approaches that could effectively target these kinases in the development of future cancer treatments.
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The Ganga is the largest river in India, serves as a lifeline for agriculture, drinking water, and religious rites. However, it became highly polluted due to the influx of industrial wastes and untreated sewages, leading to the decline of aquatic biodiversity. This study investigated the microbial diversity and plastic-xenobiotic degrading enzymes of six sediment metagenomes of river Ganga at Prayagraj (RDG, TSG, SDG) and Devprayag (KRG, BNG, BRG).

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This research portrayed the analysis of performance enhancement through a relative optimization approach of novel solar still models based on energetic-exergetic performances and energy matrices with environs-economic breakthroughs and is an extension of the existing research done by Singh & Samsher, and Singh & Gautam in the year 2022. The existing solar distiller models haven't shown relative influence on the performance of variable number of vacuum tubes, fully/partially illuminated and with/without the augmentation of parabolic concentrators among different schemes of solar still models. The present research bridges the above gaps to identify the analytical observations for the optimized results for the novel arrangement of the solar distillers compared to others.

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Background: Oral squamous cell carcinoma is one of the most common types of cancers affecting both male and female population worldwide. Currently gold standard for reconstruction of oral cavity defects is free flap reconstruction. However, in developing countries due to large case load, infrastructural and resource constraints, Pectoralis major myocutaneous flap is still widely being used.

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Background: Chickpea (Cicer arietinum L.) production is affected by many biotic factors, among them Fusarium wilt caused by Fusarium oxysporum f. sp.

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Bakanae disease caused by is an emerging disease of rice causing losses in all rice-growing regions around the world. A BCF population was developed by backcrossing the recurrent parent Pusa Basmati 1121 (PB1121) with the recombinant inbred line RIL28, which harbors a major quantitative trait locus (QTL) governing resistance to bakanae, . MassARRAY-based single-nucleotide polymorphism (SNP) assays targeting the genomic region of helped in fine mapping the QTL to a region of 130 kb between the SNP markers and using 24 recombinants.

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Pusa Basmati 1509 (PB1509) is one of the major foreign-exchange-earning varieties of Basmati rice; it is semi-dwarf and early maturing with exceptional cooking quality and strong aroma. However, it is highly susceptible to various biotic stresses including bacterial blight and blast. Therefore, bacterial blight resistance genes, namely, + and , and fungal blast resistance genes + and were incorporated into the genetic background of recurrent parent (RP) PB1509 using donor parents, namely, Pusa Basmati 1718 (PB1718), Pusa 1927 (P1927), Pusa 1929 (P1929) and Tetep, respectively.

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Purpose: To compare visual field indices in normal children and adults with similar retinal nerve fiber layer (RNFL) thickness on optical coherence tomography (OCT).

Methods: This cross-sectional study included 59 eyes of 59 normal children 6-18 years of age compared to normal adults. The children underwent visual field testing on the Humphrey Field Analyzer (HFA) and RNFL thickness measurement on OCT.

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It is of interest to assess levels of serum cornitine in male tobacco users and also find its correlation with bone mineral density. Assessment for serum cotinine levels was done using commercially available Enzyme Linked Immunosorbent Assay (ELISA Kit). While bone mineral density was measured using bone densitometry through ultrasound in the wrist region.

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Introduction Obstructive Airway Diseases (OADs) are the leading cause of death among chronic respiratory diseases worldwide, and novel therapies are direly needed. Fluticasone furoate/vilanterol (FF/Vi) (100/25 µg) is the first once-daily ICS/uLABA marketed in India for COPD since 2021. Considering its limited real-world experience in OAD patients in Indian clinical settings, a large drug utilization study (DUS) was planned.

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Pearl millet is a crucial nutrient-rich staple food in Asia and Africa and adapted to the climate of semi-arid topics. Since the genomic resources in pearl millet are very limited, we have developed a brand-new mid-density 4K SNP panel and demonstrated its utility in genetic studies. A set of 4K SNPs were mined from 925 whole-genome sequences through a comprehensive in-silico pipeline.

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Background: The development of the skin stapling technique for surgical wound closure is less time-consuming than the conventional sutures.

Aim: This study aims to evaluate the efficacy of skin staples and 4-0 prolene conventional suture in closure of extraoral surgical wounds in neck region in elective maxillofacial surgery.

Materials And Methods: The study was conducted on a total of 60 patients, who were equally divided into three groups.

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Background: Basmati is a speciality segment in the rice genepool characterised by explicit grain quality. For the want of suitable populations, genome-wide association study (GWAS) in Basmati rice has not been attempted.

Materials: To address this gap, we have performed a GWAS on a panel of 172 elite Basmati multiparent population comprising of potential restorers and maintainers.

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Background: Antioxidants detain the development and proliferation of various non-communicable diseases (NCDs). γ-oryzanol, a group of steryl ferulates and caffeates, is a major antioxidant present in rice grain with proven health benefits. The present study evaluated the distribution and dynamics of γ-oryzanol and its components in spatial and temporal scales and also delineated the effect of processing and cooking on its retention.

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Iatrogenic Cushing's syndrome is a life-threatening condition which requires an early diagnosis multidisciplinary approach. Despite reports of iatrogenic Cushing's syndrome following nasal or inhaled steroids, its development after topical betamethasone eye drops for a short duration is a less frequently reported or anticipated condition. We describe a 6-week-old infant who developed exogenous Cushing's syndrome following topical steroids after bilateral goniotomy for newborn glaucoma.

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To report the cases of five children with unilateral advanced glaucoma in isolated congenital ectropion uveae (CEU) with ipsilateral ptosis and myopia. This is an ambispective observational case series. After diagnosing one patient with CEU and glaucoma, consecutive patients presenting with unilateral ptosis, congenital iris anomaly, and glaucoma between 2014 to 2020, and had completed a minimum one-year postoperative follow-up, were analyzed.

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Background: Oral submucous fibrosis (OSMF) is a disabling, chronic, insidious potentially malignant condition of the oral cavity seen predominantly in the Indian subcontinent. Due to the idiopathic nature and various immunological changes seen in some OSMF patients, it can be considered an autoimmune disorder. Hyperimmunoglobulinemia is often seen with OSMF.

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The exploitation of heterosis through intersubspecific hybridisation between and has been a major breeding target in rice, but is marred by the cross incompatibility between the genomes. Wide compatibility (WC) is a triallelic system at the locus on chromosome 6 that ensures the specificity of hybridisation within and between and The allele that favours intercrossing is sparsely distributed in the rice gene pool and therefore warrants identification of diverse WC sources to develop superior intersubspecific hybrids. In this study, we have identified several novel WC sources through the marker-assisted screening of a large set of 950 rice genotypes.

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