A highly lipophilic terpyridine ligand as an efficient fluorescent probe for the selective detection of zinc(II) ions under biological conditions.

The present work describes the synthesis of new terpyridine (tpy) molecules possessing functionalized long alkyl chains at the 4'-position associated with a planar structure with considerable delocalization. Out of the three synthesized tpy derivatives (L1, L2, and L3), L2 containing an ester group at the end of the alkyl chain emerged as an excellent probe for the selective detection of Zn. The detection of Zn ions under biological conditions was achieved by the introduction of a distinct aliphatic undecanoic ester chain at the 4'-position of the core terpyridine ring, thereby making it more lipophilic.

Trace level detection of putrescine and cadaverine in food samples using a novel rhodanine-imidazole dyad and evaluation of its biological properties.

Biogenic amines are important indicators of food spoilage and quality. Food safety is significantly influenced by biogenic amines such as Putrescine and Cadaverine, produced by microbes during food spoilage. Herein, a colorimetric probe for detecting Putrescine and Cadaverine based on a chemo-dosimeter strategy has been proposed.

A review of the role of graphene-based nanomaterials in tackling challenges posed by the COVID-19 pandemic.

In 2020, the World Health Organization (WHO) declared a pandemic due to the emergence of the coronavirus disease (COVID-19) which had resulted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At present, the emergence of many new variants and mutants were found to be more harmful compared to the previous strains. As a result, research scientists around the world had devoted significant efforts to understand the mechanism, causes and transmission due to COVID-19 along with the treatment to cure these diseases.

Functionalized 2-Hydrazinobenzothiazole with Bithiophene as a Colorimetric Sensor for Lethal Cyanide Ions and Its Application in Food Samples.

A newly synthesized Schiff's base 2-(2-([2,2'-bithiophen]-5-ylmethylene)hydrazinyl)benzothiazole () was obtained from the condensation reaction between 2-hydrazinobenzothiazole and 2,2-bithiophene-5-carboxaldehyde. The prepared probe was subjected to a confirmation of the structural arrangement through NMR, FTIR, ESI-HRMS, and single-crystal XRD spectral analysis. The colorimetric sensor showed selectivity and sensitivity toward the cyanide (CN) ion over other common anions such as ClO, Cl, Br, F, I, NO, OH, HSO, and HPO in a partial aqueous system CHCN/HO (8:2, v/v).

Chromene-chromene Schiff base as a fluorescent chemosensor for Th and its application in bioimaging of Caenorhabditis elegans.

The manuscript presents the synthesis of a new di-chromene Schiff base (COM-CH) by combining 7-(diethylamino)-2-oxo-2H-chromene-3-carbohydrazide and 4-oxo-4H-chromene-3-carbaldehyde, and its characterization using various analytical techniques. The probe COM-CH functional group contains a hard donor atom that selectively complexes with Th ions. This report investigated COM-CH's sensing ability towards Th chromogenic and fluorogenic methods in ACN: HO (8:2, v/v) with Th ions.

A review of extraction and quantification of capsaicin and its bio insecticidal activity in food grains.

Chili peppers pungent and spicy flavor is caused by capsaicin, which is one of their active components. As well as being an important aspect of fruit quality, the hot sensation is a key attribute linked to members of the Capsicum genus. Extraction is one of the most popular techniques for separating and purifying organic materials, but the technique must be quick, affordable, adaptable, efficient, and high performing.

Multispectroscopic, virtual and insights into the photoaging defense mediated by the natural food colorant bixin.

An upsurge in early onset of photoaging due to repeated skin exposure to environmental stressors such as UV radiation is a challenge for pharmaceutical and cosmeceutical divisions. Current reports indicate severe side effects because of chemical or synthetic inhibitors of matrix metalloproteases (MMPs) in anti-skin aging cosmeceuticals. We evaluated the adequacy of bixin, a well-known FDA certified food additive, as a scavenger of free radicals and its inhibitory mechanism of action on MMP1, collagenase, elastase, and hyaluronidase.

Individually Modeled 3D Printed Toothbrush and Interproximal Brush Handle With Name for Patients With Limited Manual Dexterity.

Maintenance of proper oral hygiene is a cumbersome task when hand and finger movement is restricted. The customized handle allows better grip on the toothbrush, making it easier to brush teeth or dentures. This increases self-esteem by reducing their dependency on others.

Correction: Role of defective states in MgO nanoparticles on the photophysical properties and photostability of MEH-PPV/MgO nanocomposite.

Correction for 'Role of defective states in MgO nanoparticles on the photophysical properties and photostability of MEH-PPV/MgO nanocomposite' by Sangeetha Ashok Kumar , , 2021, , 22804-22816, DOI: 10.1039/d1cp03035c.

Influence of monomers involved in the fabrication of a novel PES based nanofiltration thin-film composite membrane and its performance in the treatment of common effluent (CETP) textile industrial wastewater.

Objective: In this article, monomers (tannic acid (TA) and m- phenylenediamine (MPD)) were used in the fabrication of a novel PES based thin-film composite nanofiltration (TFC-NF) membrane for the treatment of a common effluent treatment plant (CETP) of textile industrial wastewater.

Membrane Synthesis: PES support sheets and TFC layers were fabricated via non-solvent induced phase inversion and in-situ interfacial polymerization (IP) process. The ultra-thin active layer was synthesized via the IP process with monomers such as tannic acid (TA) and m- phenylenediamine (MPD).

Spoligotype Diversity of over Two Decades from Tiruvallur, South India.

Geographically, most tuberculosis (TB) cases in 2018 were reported from India. This TB burden is compounded by MDR-TB and XDR-TB. The strategies for the management and control of TB in the community depend on an understanding of the mode of spread of the different strains of TB isolates in the community.

An aggregation-induced emission active vitamin B cofactor derivative: application in pH sensing and detection of latent fingerprints.

Aggregation-induced emission (AIE) properties of an easy-to-prepare and structurally planar Schiff base derivative of the vitamin B6 cofactor pyridoxal (L) were investigated in DMSO-H2O mixed solvents. Compound L showed weak fluorescence (λem = 425 nm) in pure DMSO, but increasing the fraction of water in DMSO resulted in a significant fluorescence enhancement at 575 nm due to the restriction of intramolecular rotation (RIR) of L upon aggregation. SEM analyses revealed the formation of hairy micelle-like or needle-shaped self-assemblies/aggregates of L.

A light activated CMP conjugated 8-aminoquinoline turn-on fluorescent optode for selective determination of Th in an aqueous environment.

A new dibutyl(2-oxo-2-(quinolin-8-ylamino)ethyl)phosphinate (L) was designed, synthesised and developed as a light activated optode for Th determination. The sensing performance of L was studied in solution and in the polymeric membrane phase using absorbance and emission techniques. The neutral ion carrier L exhibits weak fluorescence at 400 nm in CHCN : HO (9 : 1, v/v).

Highly selective CHEF-type chemosensor for lutetium (III) recognition in semi-aqueous media.

A simple phosphoryl quinolone (L) based sensor has been synthesized for the selective recognition of Lu by spectrofluorimetric method. In methanol-water (1:1, v/v), the ligand L exhibits a weak emission peak at 400 nm upon excitation at 280 nm. Upon interaction with various f-metal and other selected metals from s, p, and d-block elements, the fluorescence of L is selectively enhanced in the presence of Lu due to the chelation enhanced fluorescence (CHEF) effects.

A new Al selective fluorescent turn-on sensor based on hydrazide-naphthalic anhydride conjugate and its application in live cells imaging.

In this communication, we have developed an optical chemosensor 2-amino N-(6-bromo-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)benzamide (NAPH) for selective detection of Al by reacting 4-bromo-1,8-naphthalic anhydride with 2-aminobenzohydrazide. In (DMSO:HO, 1:1, v/v) medium, the selective and specific nature of NAPH towards Al was observed by the quenching along with a blue-shift in the absorption of NAPH at 465 nm that resulted in the distinct colour change from light brown to colourless. The selective complexation that occurred between NAPH and Al was investigated by H NMR and DFT methods.

A biomimetic approach to conjugate vitamin B cofactor with the lysozyme cocooned fluorescent AuNCs and its application in turn-on sensing of zinc(II) in environmental and biological samples.

This communication focusses on the synthesis of red fluorescent lysozyme cocooned gold nanoclusters (Lyso-AuNCs) that have been successfully applied for the selective and specific recognition of the vitamin B cofactor pyridoxal-5'-phosphate (PLP). The red fluorescence of Lyso-AuNCs showed remarkable color change to yellow upon conjugation with PLP due to the formation of a Schiff base between the free -NH present in the lysozyme and the -CHO group of PLP. The developed PLP conjugated Lyso-AuNCs (PLP_Lyso-AuNCs) was applied for the selective turn-on recognition of Zn ions in aqueous medium.

Chemically modified cellulose strips with pyridoxal conjugated red fluorescent gold nanoclusters for nanomolar detection of mercuric ions.

One-pot approach was adopted for the synthesis of highly luminescent near-infrared (NIR)-emitting gold nanoclusters (AuNCs) using bovine serum albumin (BSA) as a protecting agent. The vitamin B cofactor pyridoxal was conjugated with the luminescent BSA-AuNCs through the free amines of BSA and then employed for the nanomolar detection of Hg in aqueous medium via selective fluorescence quenching of AuNCs. This nano-assembly was successfully applied for the real sample analysis of Hg in fish, tap water and river water.

Acetate selective fluorescent turn-on sensors derived using vitamin B6 cofactor pyridoxal-5-phosphate.

Two new Schiff base receptors have been synthesized by condensation of pyridoxal-5-phosphate with 2-aminophenol (L(1)) or aniline (L(2)). In DMSO, the receptors showed both chromogenic and 'turn-on' fluorescence responses selectively in the presence of AcO(-) and F(-). However, in mixed DMSO-H2O medium, the receptors showed AcO(-) selective 'turn-on' fluorescence without any interference from other tested anions including F(-).

Targeting ceramide metabolic pathway induces apoptosis in human breast cancer cell lines.

The sphingolipid ceramide is a pro apoptotic molecule of ceramide metabolic pathway and is hydrolyzed to proliferative metabolite, sphingosine 1 phosphate by the action of acid ceramidase. Being upregulated in the tumors of breast, acid ceramidase acts as a potential target for breast cancer therapy. We aimed at targeting this enzyme with a small molecule acid ceramidase inhibitor, Ceranib 2 in human breast cancer cell lines MCF 7 and MDA MB 231.

Selectivity enhancement of Arsenazo(III) reagent towards heavier lanthanides using polyaminocarboxylic acids: a spectrophotometric study.

A new study has been conducted to quantify lanthanide(III) ions using Arsenazo III-polyaminocarboxylic acid (PACA) system. The study disclosed two different analytically important information: (i) λmax of lanthanide-Arsenazo III complexes for lighter lanthanides like Ce(III) and Nd(III) did not shift from its original position on addition of PACA and (ii) for heavier lanthanides like Dy(III), Tm(III) and Lu(III) a new λmax at 538 nm was observed, while wavelengths at 610 nm and 654 nm were disappeared in presence of ethylenediaminetertracetic acid (EDTA) and trans-1,2-Diaminocyclohexane-N,N,N',N'-tetraacetic acid (DCTA), further the intensity of peak decreased with increase in lanthanide(III) ion concentration. Effect of ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetraacetic acid (EGTA) and N-(2-hydroxyethyl) ethylenediamine-N,N',N'-triacetic acid (EDTA-OH) on Arsenzo(III)-Ln(III) complex is very weak and there is no analytically importance of such interaction.

Design and analysis of an implantable CPW-fed X-monopole antenna for 2.45-GHz ISM band applications.

A novel antenna design that effectively covers the industrial, scientific, and medical (ISM) band at 2.45 GHz using an X-shaped structure with a coplanar waveguide (CPW) feed is described. The antenna has a compact size of 67.

Novel heterocyclic thiosemicarbazones derivatives as colorimetric and "turn on" fluorescent sensors for fluoride anion sensing employing hydrogen bonding.

Two novel heterocyclic thiosemicarbazone derivatives have been synthesized, and characterized, by means of spectroscopic and single crystal X-ray diffraction methods. Their chromophoric-fluorogenic response towards anions in competing solvent dimethyl sulfoxide (DMSO) was studied. The receptor shows selective recognition towards fluoride anion.

Mucocele in lower lip as a result of improper use of feeding bottle: a case report.

A rare case of mucocele associated with improper feeding habit has been presented. An eight-month old male child presented with swelling in lower lip which was noticed by his mother a week earlier. A thorough clinical examination and history taking gave a diagnosis of mucocele resulting from improper use of feeding bottle.

Electrochemical synthesis and characterization of TiO(2) nanoparticles and their use as a platform for flavin adenine dinucleotide immobilization and efficient electrocatalysis.

Here, we report the electrochemical synthesis of TiO(2) nanoparticles (NPs) using the potentiostat method. Synthesized particles have been characterized by using x-ray diffraction (XRD) studies, atomic force microscopy (AFM) and scanning electron microscopy (SEM). The results revealed that the TiO(2) film produced was mainly composed of rutile and that the particles are of a size in the range of 100 ± 50 nm.