Preliminary Investigation and Therapeutic Efficacy Determination of a Novel Anti-IL-17A Antibody, Indikizumab.

Purpose: The study aimed to develop and characterize Indikizumab, a novel humanized anti-IL-17A monoclonal antibody (mAb), for potential therapeutic use in inflammatory indications such as psoriasis, psoriatic arthritis, rheumatoid arthritis, and ankylosing spondylitis.

Methods: The research involved the purification of IL-17 isoforms, epitope mapping, affinity ranking, and comparative binding assessment of anti-IL-17 antibodies. The study also included cell-based neutralization assays and in vivo studies using mouse models to evaluate the efficacy of Indikizumab.

AI and business management: Tracking future research agenda through bibliometric network analysis.

This study has been designed to analyse the academic landscape of AI on the Scopus and Web of Science (WOS) indices and compare the findings. AI is one of the most prominent and preferred research areas, only a few studies are dedicated to the bibliometric aspect of it. There is a need to compare studies on AI over different databases to identify the impact and usefulness of those studies in decision-making in business management.

Independent antioxidant and anticancer properties of a novel thermostable lysozyme isolated from : in silico and in vitro studies.

In this study, we evaluated the independent anticancer properties of a novel heat-stable lysozyme derived from the thermophilic bacterium (BplzC) to identify potential alternative therapies to address the suboptimal outcomes of current cancer treatments. Using the String 10.5 database, an protein-protein interaction study predicted that BplzC was a strong functional partner of cytochrome c, indicating a potential role in cancer cell apoptosis.

Impact of sequential herbicides application on crop productivity, weed and nutrient dynamics in soybean under conservation agriculture in Vertisols of Central India.

Adoption of conservation agriculture (CA) is very slow due to weed infestations. The application of herbicides is the only viable option to deal with problem of weed management to adhere with basic principles of CA. A field experiment was carried out for three years to evaluate the expediency of different herbicides and their sequential applications under CA.

Performance of chickpea (Cicer arietinum L.) in maize-chickpea sequence under various integrated nutrient modules in a Vertisol of Central India.

Present investigation was conducted at the Research Farm of Indian Institute of Soil Science, Bhopal during 2017-18 and 2018-19 to study the performance of chickpea crop under various nutrient management modules in a Vertisol. The field experiment was set up in a randomized block design with three replications of twelve different INM modules. During the rabi seasons of 2017-18 and 2018-19, the chickpea (cv.

Deficiency of phyto-available sulphur, zinc, boron, iron, copper and manganese in soils of India.

Nutrient deficiencies in soil-crop contexts and inappropriate managements are the important reasons for low crop productivity, reduced nutritional quality of agricultural produce and animal/human malnutrition, across the world. The present investigation was carried out to evaluate nutrient deficiencies of sulphur (S) and micronutrients [zinc (Zn), boron (B), iron (Fe), copper (Cu) and manganese (Mn)] in agricultural soils of India for devising effective management strategies to achieve sustainable crop production, improved nutritional quality in crops and better animal/human health. A total of 2,42,827 surface (0-15 cm depth) soil samples were collected from agriculture fields of 615 districts lying in 28 states of India and were analysed for available S and micronutrients concentration.

Glycoproteins of arbuscular mycorrhiza for soil carbon sequestration: Review of mechanisms and controls.

Glycoproteins, e.g., glomalin related soil proteins (GRSP), are sticky organic substances produced by arbuscular mycorrhizal fungi (AMF).

Ecotoxicological effect of TiO nano particles on different soil enzymes and microbial community.

TiO nano particles (NPs) are one of the most produced nanoparticles in the world which are increasingly being released in to the soil. Soils are exposed to various level of concentration of TiO NPs, which has raised concern over the adverse influence on soil microbial community, in turn on ecosystem functions. Although, increasing number of studies on ecotoxicological effect of TiO NPs are coming up recently, however, a common conscience has yet to be reached regarding the impact of TiO NPs on soil microbial community and processes.

Potential of cotton for remediation of Cd-contaminated soils.

The present research was conducted to study the potential of cotton for the remediation of soils contaminated with Cd, to understand the biochemical basis of its tolerance to, and to investigate the plant-microbe interaction in the rhizosphere for enhancement of phytoextraction of Cd. Cotton (Bt RCH-2) was exposed to four Cd levels (0, 50, 100, and 200 mg/kg soil) in a completely randomised design and found that the plant could tolerate up to 200 mg/kg soil. Cd stress increased the total phenol, proline, and free amino acid contents in the plant leaf tissue compared with control but inhibited basal soil respiration, fluorescein diacetate hydrolysis, and activities of several enzymes viz.

Preparation of novel biodegradable starch/poly(vinyl alcohol)/bentonite grafted polymeric films for fertilizer encapsulation.

Sufficient hydroxyl moiety, ease of accessibility, biodegradability and reaction compatibility with other molecules make starch a basic ingredient for polymeric synthesis and to prepare encapsulated controlled release fertilizers. This article aims to prepare biodegradable clay-polymeric (starch/PVA) blended encapsulating films (CPSBs) from starch/PVA and economically feasible clay-fractioned bentonite for CPSB-encapsulated diammonium phosphate (DAP) production. The XRD, TEM and FTIR spectroscopy recognized the compatibility of bentonite with starch/PVA blend; several micropores in CPSB surface was visible through SEM.

In situ decomposition of crop residues using lignocellulolytic microbial consortia: a viable alternative to residue burning.

Open field burning of crop residue causes severe air pollution and greenhouse gas emission contributing to global warming. In order to seek an alternative, the current study was initiated to explore the prospective of lignocellulolytic microbes to expedite in situ decomposition of crop residues. Field trials on farmers' field were conducted in the state of Haryana and Maharashtra, to target the burning of rice and wheat residue and sugarcane trash, respectively.

Tolerance of cotton to elevated levels of Pb and its potential for phytoremediation.

Two experiments were conducted to determine the cotton plant's tolerance to Pb and its remediation potential. In the first experiment, the phytoremediation potential was determined by exposing the plant to four levels of Pb (0, 500, 750, and 1000 mg kg). The cotton plant exhibited an excellent tolerance index at Pb 1000 mg kg (root 78.

Isolation of a broad spectrum antimicrobial producing thermophilic Bacillus and characterization of its antimicrobial protein.

The hot spring water of Atri in India was believed to have disease curing property. An antibacterial producing organism was isolated and identified as Bacillus paralicheniformis by morphology, microscopy, and 16S-rRNA. Its secretion inhibited bacteria, yeast, and fungus in well-diffusion-method.

Effects of Co-composting of Municipal Solid Waste and Pigeon Pea Biochar on Heavy Metal Mobility in Soil and Translocation to Leafy Vegetable Spinach.

An experiment was conducted to study the effects of co-composted products of municipal solid waste (MSW) and pigeon pea biochar (PPB) on heavy metal mobility in soil and its uptake by spinach. Application of municipal solid waste biochar co-compost (MSWBC) significantly (p ≤ 0.05) reduced the heavy metal content in spinach leaves and roots compared to municipal solid waste compost (MSWC) amended soil.

Evaluation of Furcraea foetida (L.)Haw. for phytoremediation of cadmium contaminated soils.

In the present study, we evaluated Furcraea foetida for the phytoremediation of cadmium (Cd)-contaminated soils. We selected F. foetida because it is a drought-resistant plant, produces high biomass, and needs minimum maintenance.

Classification of Pigeonpea ( (L.) Millsp.) Genotypes for Zinc Efficiency.

Pigeonpea ( (L.) Millsp.) is grown globally for its protein-rich seed.

Fe-exchanged nano-bentonite outperforms FeO nanoparticles in removing nitrate and bicarbonate from wastewater.

Nitrate (NO) and bicarbonate (HCO) are harmful for the water quality and can potentially create negative impacts to aquatic organisms, crops and humans. This study deals with the removal of NO and HCO from contaminated wastewater using Fe-exchanged nano-bentonite and FeO nanoparticles. X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, surface area measurement and particle size analysis revealed that the adsorbents fall under the nano-scale size range with high specific surface area, and Fe was successfully exchanged in the nano-bentonite clay.

Effect of Soil Amendments on Microbial Resilience Capacity of Acid Soil Under Copper Stress.

An incubation study was undertaken to study microbial resilience capacity of acid soil amended with farmyard manure (FYM), charcoal and lime under copper (Cu) perturbation. Copper stress significantly reduced enzymatic activities and microbial biomass carbon (MBC) in soil. Percent reduction in microbial activity of soil due to Cu stress was 74.

Phylloplane bacteria of Jatropha curcas: diversity, metabolic characteristics, and growth-promoting attributes towards vigor of maize seedling.

The complex role of phylloplane microorganisms is less understood than that of rhizospheric microorganisms in lieu of their pivotal role in plant's sustainability. This experiment aims to study the diversity of the culturable phylloplane bacteria of Jatropha curcas and evaluate their growth-promoting activities towards maize seedling vigor. Heterotrophic bacteria were isolated from the phylloplane of J.

Surface tailored organobentonite enhances bacterial proliferation and phenanthrene biodegradation under cadmium co-contamination.

Co-contamination of soil and water with polycyclic aromatic hydrocarbon (PAH) and heavy metals makes biodegradation of the former extremely challenging. Modified clay-modulated microbial degradation provides a novel insight in addressing this issue. This study was conducted to evaluate the growth and phenanthrene degradation performance of Mycobacterium gilvum VF1 in the presence of a palmitic acid (PA)-grafted Arquad® 2HT-75-based organobentonite in cadmium (Cd)-phenanthrene co-contaminated water.

Aquatic microphylla Azolla: a perspective paradigm for sustainable agriculture, environment and global climate change.

This review addresses the perspectives of Azolla as a multifaceted aquatic resource to ensure ecosystem sustainability. Nitrogen fixing potential of cyanobacterial symbiont varies between 30 and 60 kg N ha(-1) which designates Azolla as an important biological N source for agriculture and animal industry. Azolla exhibits high bioremediation potential for Cd, Cr, Cu, and Zn.

RBx-0597, a potent, selective and slow-binding inhibitor of dipeptidyl peptidase-IV for the treatment of type 2 diabetes.

Dipeptidyl peptidase IV (DPP-IV) inhibiton is a well recognized approach to treat Type 2 diabetes. RBx-0597 is a novel DPP-IV inhibitor discovered in our laboratory. The aim of the present study was to characterize the pharmacological profiles of RBx-0597 in vitro and in vivo as an anti-diabetic agent.

Assessment of biological and biochemical indicators in soil under transgenic Bt and non-Bt cotton crop in a sub-tropical environment.

There is concern that transgenic Bt-crops carry genes that could have undesirable effects on natural and agro-ecosystem functions. We investigated the effect of Bt-cotton (expressing the Cry 1Ac protein) on several microbial and biochemical indicators in a sandy loam soil. Bt-cotton (MRC-6301Bt) and its non-transgenic near-isoline (MRC-6301) were grown in a net-house on a sandy clay loam soil.

Alternative soil quality indices for evaluating the effect of intensive cropping, fertilisation and manuring for 31 years in the semi-arid soils of India.

Soil quality assessment provides a tool for evaluating the sustainability of alternative soil management practices. Our objective was to develop the most sensitive soil quality index for evaluating fertilizer, farm yard manure (FYM), and crop management practices on a semiarid Inceptisol in India. Soil indicators and crop yield data from a long-term (31 years) fertilizer, manure, and crop rotation (maize, wheat, cowpea, pearl millet) study at the Indian Agricultural Research Institute (IARI) near New Delhi were used.

Neem (Azadirachta indica) seed kernel powder retards urease and nitrification activities in different soils at contrasting moisture and temperature regimes.

A laboratory experiment was conducted to examine the potentiality of a natural resource neem (Azadirachta indica) seed kernel powder (NSKP) to reduce the urease and nitrification activities in different soils (viz., normal, acid, and sodic) at contrasting moisture (1:1 soil to water and field capacity) and temperature regimes (10 degrees C and 37 degrees C). Results have revealed that application of NSKP with urea did not exhibit any urease inhibitory property in normal and sodic soils, but in acid soil it had maintained higher concentration of urea than the urea alone treated samples for two weeks after application.