Publications by authors named "Ashok K Malhotra"
Background: Small supernumerary marker chromosomes (sSMC) occur in 0.075% of unselected prenatal and in 0.044% of consecutively studied postnatal cases.
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- The study aimed to examine the incidence of Down syndrome in Dubai, assessing a total of 63,398 newborns over a 5-year period from 1999 to 2003 and confirming 141 cases.
- The overall incidence was found to be 1 in 449 live births, with higher rates among UAE nationals (1 in 319) compared to non-UAE nationals (1 in 602), and key factors included advanced maternal age and higher parity.
- The findings suggest a need for improved genetic counseling and better antenatal screening programs to alleviate the psychological and genetic impacts on families in the region.