Publications by authors named "Ashok Joseph"
While the effects of external factors like fluid mechanical forces and scaffold geometry on tissue growth have been extensively studied, the influence of cell behavior-particularly nutrient consumption and depletion within the scaffold-has received less attention. Incorporating such factors into mathematical models allows for a more comprehensive understanding of tissue-engineering processes. This work presents a comprehensive continuum model for cell proliferation within two-dimensional tissue-engineering scaffolds.
View Article and Find Full Text PDFObjective: The authors evaluated the efficacy and safety of augmenting clozapine with risperidone in patients with treatment-resistant schizophrenia.
Method: In a randomized, double-blind, placebo-controlled 12-week trial, 40 patients unresponsive or partially responsive to clozapine monotherapy received a steady dose of clozapine combined with either placebo (N=20) or up to 6 mg/day of risperidone (N=20). Patient psychopathology was assessed at 2-week intervals with the Brief Psychiatric Rating Scale (BPRS) and the Scale for the Assessment of Negative Symptoms (SANS), among other measures.
Article Synopsis
- The study aimed to investigate how "high" and "low" serum prolactin levels affect bone density and metabolism in female patients with schizophrenia.
- Using a dual-energy X-ray absorptiometer, researchers measured bone mineral density and metabolic markers in patients treated with specific antipsychotics for a year.
- Findings revealed no direct link between high prolactin levels and bone density loss, but those with elevated prolactin experienced increased rates of bone formation and resorption, suggesting that prolonged high levels might eventually disrupt bone density.