New Insights into Mechanisms of Immune Checkpoint Inhibitor-Induced Cardiovascular Toxicity.

Purpose Of Review: The review aims to summarize the present knowledge about cardiovascular toxicities associated with immune checkpoint inhibitors (ICI) and dissect underlying mechanism associated with individual cardiovascular toxicity.

Recent Findings: Widespread use of ICI therapy has allowed for increasing recognition of a wide spectrum of immune-related adverse events that leave all organ systems vulnerable. Immune-mediated cardiovascular toxicities, initially thought to be rare, are more often being reported and present considerable challenges due to their non-specific clinical presentation, potential to have a fulminant progression, and overlap with other cardiovascular and general medical illnesses.

Spontaneous Fracture in Intramural and Intra-Abdominal Segments of Peritoneal Dialysis Catheters Presenting as Outflow Failure.

We herewith report 2 unusual cases of spontaneous peritoneal dialysis (PD) catheter fracture in intramural and intra-abdominal segments, respectively, in PD patients with long vintage. There were no associated infections or mechanical trauma. The patients presented with PD catheter outflow failure.