The role of intestinal ultrasound with colour Doppler in predicting the response to biologic therapy in inflammatory bowel disease patients.

Introduction: Inflammatory bowel disease patients are exposed to frequent procedures and hospital admissions as well as recurrent need for radiological examinations with a high risk of exposure to radiation and contrast.

Aim: Our objective was to evaluate the role of a combination of both intestinal ultrasound (IUS) and colour Doppler with different parameters for monitoring changes in inflammation over time and to reveal their potential role in the assessment of response to biologic therapy in inflammatory bowel disease (IBD) patients.

Material And Methods: Before the induction of biological therapy, IUS together with colour Doppler of the intestine was conducted.

Thulium laser-based hemostasis during percutaneous nephrolithotomy: a prospective observational multicentric study.

Purpose: Percutaneous nephrolithotomy (PNL) is a controlled grade IV renal trauma and intraoperative bleeding is the most crucial complication. Contemporarily, pulsed mode thulium laser has been reported to confer adequate hemostasis. Therefore, the primary outcome of this study was to assess safety and efficacy of thulium laser-based hemostasis during PNL.

Design, synthesis and anti-proliferative evaluation of new pyridine-2,3-dihydrothiazole/thiazolidin-4-one hybrids as dual CDK2/GSK3β kinase inhibitors.

Herein, the molecular hybridization drug discovery approach was used in the design and synthesis of twelve novel pyridine-2,3-dihydrothiazole hybrids (2a,b-5a,b and 13a,b-14a,b) and fourteen pyridine-thiazolidin-4-one hybrids (6a,b-12a,b) as anti-proliferative analogues targeting CDK2 and GSK3β kinase inhibition. Almost all of the newly synthesized hybrids, including their precursors (1a,b), were evaluated for their anti-proliferative activity against three human cancer cell lines-MCF-7, HepG2 and HEp-2-as well as normal Vero cell lines. Both compounds 1a (pyridine-thiourea precursor) and 8a (pyridine-5-acetyl-thiazolidin-4-one hybrid) exhibited excellent anti-proliferative activity against HEp-2 (IC = 7.

Thermodynamic, chemical, and electrochemical studies of Aloe ferox Mill extract as a naturally developing copper corrosion inhibitor in HCl solution.

Copper can be susceptible to corrosion in acidic cleaning solutions for desalination system, especially if the solution is highly concentrated or if the cleaning process involves extended exposure to the acid. In the current work, Aloe ferox Mill (AFM extract) can be used as a natural origin corrosion inhibitor for copper in 1.0 M HCl solution.

ACTION Teens Saudi Arabia: Perceptions, attitudes, motivators, and barriers among adolescents living with obesity, caregivers, and healthcare professionals in Saudi Arabia.

Obesity is predicted to affect approximately one-quarter of children/adolescents in Saudi Arabia by 2030, but there is limited evidence regarding the perceptions, attitudes, behaviours, and barriers to effective obesity care for adolescents living with obesity (ALwO), caregivers of ALwO, and healthcare professionals (HCPs). We report data from 500 ALwO (aged 12-<18 years), 500 caregivers, and 200 HCPs surveyed in Saudi Arabia as part of the global, cross-sectional ACTION Teens study (NCT05013359). Nearly all respondents recognized that obesity has a strong impact on overall health (ALwO 88%; caregivers 85%; HCPs 90%).

An electrochemical, and surface studies of synthesized Gemini ionic liquid as corrosion inhibitor for carbon steel in petroleum field.

In this work, we study the efficiency of N, N-dibenzyl-N, N, N, N-tetramethylpropane-1,3-diaminium chloride, as anticorrosion. This compound exhibits potential as a prospective remedy to stop the deterioration of carbon steel caused by corrosion in 1.0 M HCl.

Gamma radiation-induced grafting of poly(butyl acrylate) onto ethylene vinyl acetate copolymer for improved crude oil flowability.

Ethylene vinyl acetate (EVA) copolymers are widely employed as pour point depressants to enhance the flow properties of crude oil. However, EVA copolymers have limitations that necessitate their development. This work investigated the modification of EVA via gamma radiation-induced grafting of butyl acrylate (BuA) monomers and the evaluation of grafted EVA as a pour point depressant for crude oil.

Correction to "Anticorrosion Agents for Carbon Steel in Acidic Environments: Synthesis and Quantum Chemical Analysis of New Schiff Base Compounds with Benzylidene".

[This corrects the article DOI: 10.1021/acsomega.3c05790.

Oral bioavailability enhancement of doxazosin mesylate: Nanosuspension versus self-nanoemulsifying drug delivery systems.

Background And Purpose: Doxazosin mesylate (DOX) is an antihypertensive drug that possesses poor water solubility and, hence, poor release properties. Both nanosuspensions and self-nanoemulsifying drug delivery systems (SNEDDS) are becoming nanotechnology techniques for the enhancement of water solubility of different drugs.

Experimental Approach: The study's goal was to identify the best drug delivery system able to enhance the release and antihypertensive effect of DOX by comparing the physical characteristics such as particle size, zeta potential, entrapment efficiency, release rate, and main arterial blood pressure of DOX-loaded nanosuspensions and SNEDDS in liquid and solid form.

Assessment of toxicity and antimicrobial performance of polymeric inorganic coagulant and evaluation for eutrophication reduction.

In this study, the efficacy of the promising iron-based polymeric inorganic coagulant (POFC) was assessed for the reduction of eutrophication effect (freshwater toxicity) and the microbial loads from wastewater. Toxicity assessment for POFC was conducted on mice and skin cell lines. The results confirm the lower toxicity level of POFC.

Green Synthesis of a Novel Cationic Surfactant Based on an Azo Schiff Compound for Use as a Carbon Steel Anticorrosion Agent.

The new cationic surfactant-based azo Schiff compound (azoS8) was prepared, characterized, and investigated as a corrosion inhibitor for carbon steel in 1 M HCl by means of electrochemical approaches in this study. The chemical structure of azoS8 has been verified by the FTIR and H NMR spectra. According to the electrochemical system, the examined surfactant is a mixed-type inhibitor.

High Incidence of Acute Liver Failure among Patients in Egypt Coinfected with Hepatitis A and Hepatitis E Viruses.

Hepatitis A virus (HAV) and Hepatitis E virus (HEV) are transmitted through the fecal-oral route. HAV outbreaks and one HEV outbreak have been reported in Egypt. However, the impact of HAV-HEV co-infection is not known.

Formulation and in vitro characterization of nanoemulsions containing remdesivir or licorice extract: A potential subcutaneous injection for coronavirus treatment.

The management of coronavirus necessitates that medicines are available, reasonably priced, and easy to administer. The work aimed at formulating and characterizing remdesivir and licorice extract nanoemulsions and comparing their efficacy against coronavirus for further subcutaneous injection. First, the solubility of remdesivir was determined in different oils, surfactants, and co-surfactants to choose the optimal nanoemulsion components.

The Impact of Corrosion Inhibitors in Desalination Systems.

In this review, the importance of corrosion inhibitors in desalination plants is briefly discussed, with an emphasis on the various types for effective corrosion control techniques. The review highlighted the most significant corrosion inhibitors used in desalination plants for minimizing the corrosiveness of the source water throughout pretreatment, reverse osmosis, and post-treatment stages. Water composition, temperature and pressure, pH, dissolved oxygen, flow velocity, chloride content, fouling, and scaling are all described as factors affecting corrosion in desalinated water.

Optimization of oil yield of Pelargonium graveolens L'Hér using Box-Behnken design in relation to its antimicrobial activity and in silico study.

Pelargonium graveolens L'Hér is an important species of genus Pelargonium with an economic value. The unique rose scent of its oil is used in perfume and cosmetic industry. The oil is characterized by the presence of citronellol, geraniol and rose oxide.

Anticorrosion Agents for Carbon Steel in Acidic Environments: Synthesis and Quantum Chemical Analysis of New Schiff Base Compounds with Benzylidene.

Novel Schiff bases (SBs), namely, ,-bis(2-(((E)-4-chlorobenzylidene)amino)ethyl)ethane-1,2-diamine (I), ,-bis(2-(((E)-4-(dimethylamino)benzylidene)amino)ethyl)ethane-1,2-diamine (II), and ,'-(ethane-1,2-diyl)bis(-((((Z)-4-dimethylamino)benzylidene) amino)methylethane-1,2-diamine) (III), were prepared and characterized by using elemental analysis, IR, and H NMR spectroscopy. For assessing carbon steel in diverse settings, with and without inhibitors at varying concentrations, electrochemical frequency modulation (EFM), electrochemical impedance spectroscopy (EIS), and potentiodynamic polarization (PP) techniques were employed. The results showed that the synthesized inhibitors effectively decreased the corrosion rate of carbon steel in acidic media and the inhibition efficiency reached up to 93% for compound III at a concentration of 250 ppm.

Corrosion inhibition of mild steel in 1 M HCl by pyrazolone-sulfonamide hybrids: synthesis, characterization, and evaluation.

Carbon steel is widely used in the petroleum industry for pipelines, storage tanks, and equipment due to its mechanical properties, and strength. However, challenges such as environmental conditions and corrosive materials can affect its lifespan and require maintenance and repair. This work aimed to prepare pyrazalone-sulfonamide hybrids, and confirmed by mass spectra, FTIR, H-NMR, and C-NMR.

Synthesis, description, and application of novel corrosion inhibitors for CS AISI1095 in 1.0 M HCl based on benzoquinoline derivatives.

This study aims to synthesize and evaluate the corrosion inhibition properties of three newly prepared organic compounds based on benzo[h]quinoline hydrazone derivatives. The compounds structure were characterised using FTIR, 1H-NMR, 13C-NMR and Mass spectroscopy. Electrochemical methods, including Potentiodynamic Polarization (PP), Electrochemical Frequency Modulation (EFM), and Electrochemical Impedance Spectroscopy (EIS) were employed to evaluate the compounds as corrosion inhibitors in HCl (1.

Electrochemical and theoretical investigations of favipiravir drug performance as ecologically benign corrosion inhibitor for aluminum alloy in acid solution.

Aluminum-silicon alloys have become a preferred option in the automotive and aerospace industries thanks to their fault-tolerant process ability and reasonable static characteristics at relatively affordable costs. This study aimed to investigate the use of favipiravir (FAV) drug as a biocompatible and eco-friendly inhibitor to protect aluminum alloy (AlSi) surface in an aggressive acid environment (1.0 M HCl).

First Report on Abnormal Renal Function in Acute Hepatitis E Genotype 1 Infection.

Impaired renal functions have been reported with Hepatitis E virus (HEV) infections, especially with genotypes 3 and 4. These complications were reported during the acute and chronic phases of infection. HEV genotype 1 causes acute infection, and the effect of HEV-1 infections on renal functions is not known.

Novel Gemini ionic liquid for oxidative desulfurization of gas oil.

The N,N,N,N-tetramethyl -N,N-diphenylpropane-1,3-diaminium dichloride ionic liquid (ILc) is an environmentally friendly catalyst for oxidative-extractive desulfurization of gas oil (sulfur content = 2400 ppm) in the presence of HO as an oxidizing agent. The precise structure of the prepared IL was confirmed using FT-IR spectroscopy, andH-NMR. The reaction temperature, IL ratios, HO dosage, and reaction time were studied to assess their effects on the desulfurization efficiency.

Formulation and evaluation of alginate-gelatin hydrogel scaffolds loaded with zinc-doped hydroxyapatite and 5-fluorouracil.

Alginate and gelatin are natural macromolecules used to formulate biocompatible drug delivery systems. Hydroxyapatite (HA) is an osteophilic ceramic used to prepare bone scaffolds. The current study aimed at preparing and characterizing HA, zinc-doped HA, and 5-fluorouracil(5-FU)-loaded alginate-gelatin-based hydrogel scaffolds using different crosslinking solutions.

Characteristics and outcomes of acute hepatitis of unknown etiology in Egypt: first report of adult adenovirus-associated hepatitis.

Purpose: Several outbreaks of acute hepatitis of unknown etiology (AHUE) in children were reported in 2022 in many countries, with adenovirus identified as the etiological agent in most of them. We aimed to evaluate the characteristics and outcomes of AHUE cases in Egypt.

Methodology: Hospitalized patients with acute hepatitis were included in the study.

Optimization of Meloxicam Solid Dispersion Formulations for Dissolution Enhancement and Storage Stability Using 3 Full Factorial Design Based on Response Surface Methodology.

This study aimed to formulate and optimize solid-dispersion of meloxicam (MX) employing response-surface-methodology (RSM). RSM allowed identification of the main effects and interactions between studied factors on MX dissolution and acceleration of the optimization process. 3 full factorial design with 27 different formulations was proposed.