Publications by authors named "Ashlynn A Gallagher"
The voltage-gated calcium channel subunit α2δ-2 controls calcium-dependent signaling in neurons, and loss of this subunit causes epilepsy in both mice and humans. To determine whether mice without α2δ-2 demonstrate hippocampal activation or histopathological changes associated with seizure activity, we measured expression of the activity-dependent gene c and various histopathological correlates of temporal lobe epilepsy (TLE) in hippocampal tissue from wild-type (WT) and α2δ-2 knock-out ( KO) mice using immunohistochemical staining and confocal microscopy. Both genotypes demonstrated similarly sparse c- and expressions within the hippocampal dentate granule cell layer (GCL) at baseline, consistent with no difference in basal activity of granule cells between genotypes.
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- * Even though knockout (KO) mice showed fewer active cells in the dentate gyrus after handling-induced seizures, they exhibited increased activation when given a low dose of a seizure-inducing drug compared to wildtype (WT) mice, indicating heightened sensitivity to convulsions.
- * Histopathological markers, such as neurogenesis and glial activation, were largely similar in both KO and WT mice, except for a notable increase in hilar mossy cell density in KO mice,