Publications by authors named "Ashley Wynne"
Article Synopsis
- Asthma causes inflammation and mucus buildup in the lungs, impacting airflow and making it difficult for orally or inhaled drugs to work effectively.
- This study tested the diffusion of two asthma medications, theophylline and albuterol, through an artificial mucus layer, measuring their concentration over time using special spectroscopy techniques.
- The results yielded diffusion coefficients for the drugs, which matched previous studies, and demonstrated a novel, non-invasive method to evaluate how well drugs can penetrate through complex mucus conditions.
Health-related quality of life and tuberculosis: a longitudinal cohort study.
Health Qual Life Outcomes
May 2015
Article Synopsis
- The study compared health-related quality of life (HRQOL) among individuals with active tuberculosis (TB), those with latent TB infection (LTBI), and a control group over one year.
- Participants underwent evaluations using the SF-36 survey, revealing that those with active TB experienced significantly lower HRQOL immediately after diagnosis but showed improvement over time.
- In contrast, participants treated for LTBI and the control group maintained similar HRQOL scores throughout the study period.
Purpose: To estimate health utility derived from the Short Form-36 (SF-36) questionnaire and Standard Gamble instrument for persons diagnosed and treated for tuberculosis (TB) disease, those diagnosed and treated for latent TB infection (LTBI), and those screened but not treated for TB disease or LTBI over the year following their diagnosis/initial assessment.
Methods: Participants were recruited at two Montreal hospitals (2008-2011) and completed the SF-36 and Standard Gamble at baseline and at follow-up visits 1, 2, 4, 6, 9, and 12 months thereafter. SF-6D health utility scores were derived from SF-36 responses.
The threat of tuberculosis (TB) in Uganda cannot be considered in isolation from the HIV/AIDS epidemic. Stigma contributes to delays in seeking treatment and poor adherence for both TB and HIV patients. This study aims to assess and describe stigma and predictors of stigma related to TB and HIV in the population of western Uganda.
View Article and Find Full Text PDFBackground: In Uganda, despite a significant public health burden of tuberculosis (TB) in the context of high human immunodeficiency virus (HIV) prevalence, little is known about community knowledge of TB. The purpose of this study was to assess and compare knowledge about TB and HIV in the general population of western Uganda and to examine common knowledge gaps and misconceptions.
Methods: We implemented a multi-stage survey design to randomly survey 360 participants from one district in western Uganda.