Publications by authors named "Ashley V Cabrera"
Metabolic diseases such as type 2 diabetes and obesity pose a significant global health burden. Plant-based diets, including vegan diets, are linked to favorable metabolic outcomes, yet the underlying mechanisms remain unclear. In a randomized trial involving 21 pairs of identical twins, we investigated the effects of vegan and omnivorous diets on the host metabolome, immune system, and gut microbiome.
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- About 15% of US adults have high uric acid levels linked to gout, while most mammals use the enzyme uricase to eliminate it, which humans lack due to evolutionary changes.
- Researchers discovered a bacterial gene cluster in the gut that can degrade uric acid into other compounds like xanthine and fatty acids.
- Removing gut bacteria in mice without uricase led to high uric acid levels, suggesting that gut microbiota play a role in uric acid excretion and indicating potential new treatments targeting the microbiome for hyperuricemia.