Publications by authors named "Ashley Sunderland"
Article Synopsis
- Brain metastases significantly impact patients with metastatic melanoma, with a severe prognosis and limited durable responses to combined immune checkpoint inhibitors like PD-1 and CTLA-4, especially in symptomatic cases.
- Research shows that natural killer (NK) cells play a crucial role in enhancing the effectiveness of immune therapy against brain tumors, while their depletion leads to poorer outcomes and decreased CD8+ T cell levels within tumors.
- The study reveals that the effectiveness of PD-1/CTLA-4 blockade is dependent on chemokine-driven trafficking of CD8+ T cells to intracranial tumors, highlighting the complexity of immune responses in the brain.
Exit of quiescent disseminated cancer cells from dormancy is thought to be responsible for metastatic relapse and a better understanding of dormancy could pave the way for novel therapeutic approaches. We used an model of triple negative breast cancer brain metastasis to identify differences in transcriptional profiles between dormant and proliferating cancer cells in the brain. gene, encoding a small proteoglycan biglycan, was strongly upregulated in dormant cancer cells .
View Article and Find Full Text PDFBackground: Brain metastases (BrM) develop in 20-40% of cancer patients and represent an unmet clinical need. Limited access of drugs into the brain because of the blood-brain barrier is at least partially responsible for therapeutic failure, necessitating improved drug delivery systems.
Methods: Green fluorescent protein (GFP)-transduced murine and nontransduced human hematopoietic stem cells (HSCs) were administered into mice (n = 10 and 3).