Publications by authors named "Ashley Qin"
Article Synopsis
- - Large biobanks that combine electronic health records with genetic data enable detailed studies on genetics related to complex diseases, focusing on age of onset, progression, and lifespan.
- - The proposed frailty model for analyzing these genetic associations considers population structure and relatedness, employing advanced optimization techniques to handle high computational demands.
- - The effectiveness of this method was validated using simulations and real data from around 400,000 UK Biobank participants and 180,000 FinnGen participants, yielding insights into 871 traits related to time-to-event phenotypes.
Splicing factor mutations are common among cancers, recently emerging as drivers of myeloid malignancies. U2AF1 carries hotspot mutations in its RNA-binding motifs; however, how they affect splicing and promote cancer remain unclear. The U2AF1/U2AF2 heterodimer is critical for 3' splice site (3'SS) definition.
View Article and Find Full Text PDFIn vivo models that recapitulate human erythropoiesis with persistence of circulating red blood cells (RBCs) have remained elusive. We report an immunodeficient murine model in which combined human liver and cytokine humanization confer enhanced human erythropoiesis and RBC survival in the circulation. We deleted the fumarylacetoacetate hydrolase () gene in MISTRG mice expressing several human cytokines in place of their murine counterparts.
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