Novel in-situ longitudinal model for the study of dentifrices on dental erosion-abrasion.

A novel longitudinal erosion-abrasion in-situ model was proposed. In an exploratory test (phase 1) toothbrushing effect was investigated using a parallel design, whereas in the main study (phases 1 + 2), a crossover design tested the effect of fluoride dentifrice. In phase 1, 16 subjects (n = 5-6 subjects per group) wore partial dentures with enamel specimens for 28 d and adhered to one of the following treatment regimens: regimen A, erosion only; regimen B, erosion + toothbrushing with fluoride-containing dentifrice [1,100 ppm of fluoride as sodium fluoride (NaF)]; and regimen C, erosion + toothbrushing with placebo dentifrice (0 ppm fluoride).

Development of labeled magnitude scales for the assessment of pain of dentin hypersensitivity.

Aims: To develop and test labeled magnitude (LM) scales that are sensitive to variations in pain associated with dentin hypersensitivity (DH).

Methods: Qualitative methods were used first to obtain words that describe the pain of DH. Magnitude estimation was then used to determine the position of these descriptive terms by relative magnitude along four vertical LM scales.

A comparative evaluation of the efficacy of two novel desensitising dentifrices.

A comparison of the desensitising efficacy of two commercially available dentifrices with different modes of action was conducted in a randomised, examiner-blind, two-arm, parallel group, 8-week, longitudinal clinical study. Dentifrice A, (Sensodyne Multi Action Iso-Active), contained 50000 ppm KNO(3) and 1450 ppm fluoride as NaF. Dentifrice B, Colgate Sensitive Pro-Relief, contained a combination of 80000 ppm arginine, bicarbonate, calcium carbonate, and 1450 ppm fluorine as NaMFP.

Overview of the clinical evidence for the use of NovaMin in providing relief from the pain of dentin hypersensitivity.

Dentin hypersensitivity is a common condition that affects the adult population worldwide. NovaMin is technically described as amorphous sodium calcium phosphosilicate, and has been shown in laboratory studies to rapidly occlude dentin tubules and form a protective hydroxyapatite-like layer on the dentin surface. A number of clinical studies investigating the efficacy of NovaMin for the relief of pain from dentin hypersensitivity have been conducted in the United States, Ireland, China, and India.

Construction and validation of the quality of life measure for dentine hypersensitivity (DHEQ).

Aim: To develop and validate a condition specific measure of oral health-related quality of life for dentine hypersensitivity (Dentine Hypersensitivity Experience Questionnaire, DHEQ).

Materials And Methods: Questionnaire construction used a multi-staged impact approach and an explicit theoretical model. Qualitative and quantitative development and validation included in-depth interviews, focus groups and cross-sectional questionnaire studies in a general population (n=160) and a clinical sample (n=108).

Design and construction of a magnetic resonance compatible multi-injector gas jet delivery system.

We present the design, construction, and performance of a novel multi-injector gas jet delivery capable of operating in a magnetic resonance imaging environment. This apparatus is computer controlled and built with two separate pneumatic circuits enabling gas jet applications at variable sites through four independently activated injectors. Gas jet delivery is fully controllable in terms of pressure, flow rate, gas temperature, application time, and duration of interstimulus interval.

Pharmacodynamic and pharmacokinetic effects in gingival crevicular fluid from re-dosing during brushing.

The IntelliClean System from Sonicare and Crest combines a rechargeable sonic power toothbrush and a novel liquid toothpaste into one integrated system, providing the opportunity to re-dose with toothpaste during the brushing cycle. The purpose of this study was to investigate cleaning effects from in-mouth re-dosing with toothpaste during the brushing cycle vs conventional bolus dosing. This was a randomized, examiner-blind, six-period, crossover clinical study.

Effect of a novel integrated power toothbrush and toothpaste oral hygiene system on gingivitis.

The purpose of this article is to compare the gingivitis reduction efficacy relative to baseline of an integrated power toothbrush/toothpaste dispensing system prototype, the IntelliClean System from Sonicare and Crest. This was a randomized, controlled, parallel-group, examiner-blind study that examined the gingivitis reduction efficacy of a novel integrated system compared to a positive control consisting of manual toothbrushing coupled with daily flossing over a 4-week period. Mean change from baseline for gingival index (GI) and bleeding scores were tested using paired t tests for each treatment group, separately.

A novel oral hygiene system through integration of a sonic toothbrush and liquid toothpaste.

A novel system for home oral hygiene, the IntelliClean System from Sonicare and Crest is an integrated sonic toothbrush and liquid-toothpaste dispensing system. New research has established the ability of this system to reduce plaque, especially in interproximal regions, and to reduce gingivitis. The unique capability for the user to reapply liquid toothpaste during brushing (ie, re-dose) allows for a greater reduction in bacteria in the sulcus and an enhanced in-use experience that leads to improved compliance with brushing instruction, specifically longer brushing times.

Delivery, substantivity and clinical response of a direct application percarbonate tooth whitening film.

Purpose: A novel overnight bleaching system containing 19% sodium percarbonate and silicone film forming agents (Crest Night Effects) is described, along with research supporting the substantivity of the product on tooth surfaces and its resulting whitening efficacy.

Methods: Nine adult volunteers were enrolled in a study to determine overnight retention (substantivity) of the product. A non-reactive blue pigment was added to the product to aid in evaluating retention.

A clinical study to assess the breath protection efficacy of denture adhesive.

This randomized and controlled, examiner-blind, 3-period, crossover clinical trial was designed to determine the effect of an experimental denture adhesive, a marketed denture adhesive (European Fixodent( Fresh), or no denture adhesive on the breath odor of 37 adults wearing full maxillary and mandibular dentures. Breath quality was measured at baseline and at 3 and 6 hours after the start of each treatment period via monitoring of volatile sulfur compounds (VSCs) using a halimeter and second-person organoleptic grading. A 48-hour washout phase separated treatment periods.