Oxytetracycline concentrations in interstitial fluid from tissue chambers inoculated with after intramuscular or intrachamber administration in sheep.

Objective: To determine oxytetracycline concentrations in plasma and in fluid from (CPT)-inoculated tissue chambers (used as experimental abscess models) and uninoculated (control) tissue chambers in sheep after IM or local administration of the drug and to investigate whether CPT growth was reduced or eliminated by these treatments.

Animals: 10 clinically normal female sheep.

Procedures: Sterile tissue chambers were surgically implanted in both paralumbar fossae of each sheep; ≥ 2 weeks later (day -6), 1 randomly selected chamber was inoculated with CPT, and the opposite chamber was injected with sterile growth medium.