Publications by authors named "Ashley Moyett"
Article Synopsis
- Schizotypy, which indicates a person's vulnerability to psychosis, is linked to both childhood trauma and structural brain changes.
- A study involving 1182 healthy adults found that interactions between schizotypy levels and childhood trauma exposure affect brain morphology, specifically in regions related to cognitive processing.
- Results suggest that individuals with high levels of both schizotypy and childhood trauma show significant variations in brain regions important for cognition, indicating that trauma may intensify the effects of schizotypy on brain structure.
Clinical response to antipsychotic drug treatment is highly variable, yet prognostic biomarkers are lacking. The goal of the present study was to test whether the fractional amplitude of low-frequency fluctuations (fALFF), as measured from baseline resting-state fMRI data, can serve as a potential biomarker of treatment response to antipsychotics. Patients in the first episode of psychosis (n = 126) were enrolled in two prospective studies employing second-generation antipsychotics (risperidone or aripiprazole).
View Article and Find Full Text PDFContributions of Parasympathetic Arousal-Related Activity to Cognitive Performance in Patients With First-Episode Psychosis and Control Subjects.
Biol Psychiatry Cogn Neurosci Neuroimaging
February 2023
Background: Cognitive impairment is integral to the pathophysiology of psychosis. Recent findings implicate autonomic arousal-related activity in both momentary fluctuations and individual differences in cognitive performance. Although altered autonomic arousal is common in patients with first-episode psychosis (FEP), its contribution to cognitive performance is unknown.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzed neuroanatomical differences in healthy individuals with varying levels of schizotypy, a personality trait linked to psychosis risk, using data from over 3,000 participants globally.
- Researchers discovered that individuals with higher schizotypy had thicker areas in the medial orbitofrontal/ventromedial prefrontal cortex (mOFC/vmPFC).
- The findings indicate that there are distinct neuroanatomical patterns correlated with schizotypy and underscore its similarity with changes observed in schizophrenia, suggesting a potential continuum between normal and psychotic states.
Most individuals with psychotic disorders relapse over their course of illness, yet the neural processes that may lead to symptom worsening are poorly understood. Importantly, such processes could be potentially affected by antipsychotic adherence status upon relapse (i.e.
View Article and Find Full Text PDFThe present study examined the role of executive control functions (ECF) in adaptive risk-taking during adolescence. Healthy individuals aged 8-25 were administered ECF measures and the Balloon Analogue Risk Task (BART), a computerized measure of risk-taking propensity. Findings demonstrated that adolescents who executed a more consistent response strategy evidenced better performance on the BART.
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