Publications by authors named "Ashley Morris-Engemann"
Infectious diseases are important causes of morbidity and mortality in patients with cancer. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Prevention and Treatment of Cancer-Related Infections characterize the major pathogens to which patients with cancer are susceptible, with a focus on the prevention, diagnosis, and treatment of major common and opportunistic infections. This portion of the guidelines highlights the sections on antifungal and antiviral prophylaxis.
View Article and Find Full Text PDFArticle Synopsis
- High-dose cyclophosphamide (Cy) is used for mobilizing hematopoietic stem cells before autologous stem cell transplantation (ASCT) in multiple myeloma (MM) but its benefits compared to G-CSF alone are uncertain.
- The study analyzed 167 newly diagnosed MM patients, finding that Cy+G-CSF led to a higher collection of CD34+ cells but increased hospitalization rates due to toxicity.
- Long-term outcomes showed no significant difference between Cy+G-CSF and G-CSF alone, suggesting that Cy may not be necessary in routine stem cell mobilization for MM and highlighting the need for randomized trials to further assess its risks and benefits.
Survival after hematopoietic stem cell transplantation (HSCT) has improved and the number of allogeneic HSCTs performed annually in the United States is expected to reach 10,000 by 2015. The National Marrow Donor Program created the System Capacity Initiative to formulate mechanisms to care for the growing number of HSCT recipients. One proposed method to increase capacity is utilization of pharmacists to manage drug therapy via collaborative practice agreements (CPAs).
View Article and Find Full Text PDFPrevention and treatment of cancer-related infections.
J Natl Compr Canc Netw
November 2012
Patients with cancer are at increased risk for developing infectious complications during the course of their disease and treatment. The following sections of the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Prevention and Treatment of Cancer-Related Infections provide an overview of the risk factors for infectious complications, recommendations for infectious risk categorization, and strategies for prevention of infections in high-risk patient populations with cancer. Individualized risk evaluation for infections and incorporation of preventative measures are essential components of the overall spectrum of cancer care, and may contribute to optimizing treatment outcomes for patients.
View Article and Find Full Text PDFObjective: To evaluate the use of rituximab in the clinical management of steroid-refractory chronic graft-versus-host disease (GVHD).
Data Sources: Literature was accessed through MEDLINE and International Pharmaceutical Abstracts (1990-September 2008), both indexed and nonindexed citations, using the terms rituximab, graft-versus-host disease, monoclonal antibodies, and CD20. In addition, reference citations from the publications identified were reviewed.