Affinity-based proteomics reveals novel binding partners for Rab46 in endothelial cells.

Rab46 is a novel Ca-sensing Rab GTPase shown to have important functions in endothelial and immune cells. The presence of functional Ca-binding, coiled-coil and Rab domains suggest that Rab46 will be important for coupling rapid responses to signalling in many cell types. The molecular mechanisms underlying Rab46 function are currently unknown.