Publications by authors named "Ashley M Wilde"
Comparing rates of recurrent infection for first occurrence of between tapered oral vancomycin and standard vancomycin: a retrospective, propensity matched cohort study.
Infect Control Hosp Epidemiol
October 2024
Article Synopsis
- * The study was retrospective and involved matching patients based on age and antibiotic usage to analyze recurrence rates, finding a significantly lower recurrence rate in the tapered vancomycin group (5.3%) compared to the standard group (28%).
- * The results suggest that tapering vancomycin might be a more effective treatment for initial CDI infections, but more extensive studies are needed to confirm these findings.
Article Synopsis
- A study was conducted to investigate the prevalence and outcomes of community-acquired pneumonia (CAP) in immunocompromised hosts (ICHs) compared to non-ICHs among hospitalized adults in Louisville from June 2014 to May 2016.
- Out of 7449 patients with CAP, 10% were identified as immunocompromised, with advanced-stage cancer being the most common condition.
- The study found that ICHs had significantly higher mortality rates at hospitalization (9% vs 5%), 30 days (24% vs 11%), 6 months (44% vs 21%), and 1 year (53% vs 27%) compared to non-ICHs, highlighting the impact of socioeconomic
Implementation of a pharmacy-driven rapid bacteremia response program.
Am J Health Syst Pharm
January 2024
Purpose: This report describes a comprehensive pharmacy-driven rapid bacteremia response program.
Summary: This novel program positioned the pharmacy department at a large, community health system to receive and respond to critical microbiologic diagnostic testing results, 24/7/365. The program empowered pharmacists to provide centralized, comprehensive care including assessing blood culture Gram stain results, adjusting antibiotic therapy per protocol, ordering repeat blood cultures, analyzing and interpreting rapid molecular diagnostic test results, placing orders for contact isolation, and communicating antibiotic recommendations to the treatment team.
Limited impact of a nudge comment in promoting de-escalation to first-generation cephalosporins in urinary tract infections.
Antimicrob Steward Healthc Epidemiol
September 2022
In this study, we evaluated the impact of a microbiology nudge on de-escalation to first-generation cephalosporins in hospitalized patients with urinary tract infections secondary to , , and isolates with minimum inhibitory concentrations (MICs) ≤ 16 µg/mL. De-escalation to first generation-cephalosporins was uncommon at MICs = 4-16 µg/mL.
View Article and Find Full Text PDFFluoroquinolone stewardship at a community health system: A decade in review.
Antimicrob Steward Healthc Epidemiol
November 2022
Objective: To describe inpatient fluoroquinolone use and susceptibility data over a 10-year period after the implementation of an antimicrobial stewardship program (ASP) led by an infectious diseases pharmacist starting in 2011.
Design: Retrospective surveillance study.
Setting: Large community health system.
Purpose: To describe the Norton Healthcare electronic antimicrobial stewardship program (E-ASP), a novel prospective audit and feedback approach that leverages the electronic medical record to overcome efficiency barriers. Additionally, to describe an accompanying opt-out antimicrobial stewardship approach that addresses provider nonresponsiveness.
Summary: Prospective audit and feedback is recommended by antimicrobial stewardship guidelines; however, execution can be difficult due to labor requirements, delays in communication, and provider nonparticipation.
Background: Adult vaccination programs are suboptimal.
Methods: Pneumococcal vaccination history, and healthcare contact were assessed in patients with invasive pneumococcal disease.
Results: Of the 229 cases, 14% were vaccinated.
Antimicrobial stewardship in patients with confirmed coronavirus disease 2019 (COVID-19).
Infect Control Hosp Epidemiol
November 2022
Hospitalized coronavirus disease 2019 (COVID-19) patients receiving antibiotics (n = 173) were retrospectively assigned to the early or late discontinuation groups. The length of therapy was shorter in the early discontinuation group (3 vs 7 days; < .0001).
View Article and Find Full Text PDFArticle Synopsis
- The COVID-19 pandemic started in Wuhan, China in December 2019 and has rapidly spread across the globe, challenging healthcare systems.
- Healthcare providers faced risks due to insufficient personal protective equipment while trying to care for an overwhelming number of severely ill patients.
- Our healthcare system in Kentucky implemented proactive measures to protect providers, staff, and patients by focusing on three key strategies.
Saccharomyces boulardii for the prevention of hospital onset Clostridium difficile infection.
J Gastrointestin Liver Dis
March 2015
Background And Aims: Probiotics, including Saccharomyces boulardii, have been advocated for the prevention of Clostridium difficile infection. The aim of this project was to evaluate the effects of the removal of S. boulardii from an automatic antibiotic order set and hospital formulary on hospital onset C.
View Article and Find Full Text PDFStudy Objective: To assess the impact of noncompliance with a ventilator-associated pneumonia (VAP) computerized clinical pathway (CCP) on antibiotic use after removal of prospective antibiotic stewardship resources.
Design: Retrospective, observational, quasi-experimental study.
Setting: Three intensive care units (medical, surgical, and neurotrauma) in a large, tertiary care hospital.