Publications by authors named "Ashley M Rumple"

Article Synopsis
  • Angelman syndrome (AS) is a severe neurodevelopmental disorder linked to the loss of function of a maternally inherited gene, leading to issues in brain growth and function.
  • Research using maternal knock-out mice indicates that microcephaly in AS is primarily caused by reduced growth in white matter tracts, with abnormally small axons affecting nerve conduction.
  • The findings suggest that impaired axon growth is a key factor in AS and highlight the potential of structural neuroimaging for evaluating treatments.
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Prenatal cocaine exposure has been associated with numerous behavioral phenotypes in clinical populations, including impulsivity, reduced attention, alterations in social behaviors, and delayed language and sensory-motor development. Detecting associated changes in brain structure in these populations has proven difficult, and results have been inconclusive and inconsistent. Due to their more controlled designs, animal models may shed light on the neuroanatomical changes caused by prenatal cocaine; however, to maximize clinical relevance, data must be carefully collected using translational methods.

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