Publications by authors named "Ashley M Palmer"
Article Synopsis
- Niemann-Pick disease type C (NPC) is a rare and fatal disease that affects lipid storage and has limited treatment options, characterized by significant brain damage and myelination issues.
- Previous research found that recombinant human heat shock protein 70 (rhHSP70) and arimoclomol could reduce harmful lipid levels and improve neurological symptoms in mouse models of NPC.
- The current study showed that treatments with bimoclomol or rhHSP70 enhanced myelination and increased mature oligodendrocytes in affected mice, highlighting the potential of HSP-amplifying therapies for NPC treatment.
Clinical vitamin B deficiency can result in megaloblastic anemia, which results from the inhibition of DNA synthesis by trapping folate cofactors in the form of 5-methyltetrahydrofolate (5-methylTHF) and subsequent inhibition of de novo thymidylate (dTMP) biosynthesis. In the cytosol, vitamin B functions in the remethylation of homocysteine to methionine, which regenerates THF from 5-methylTHF. In the nucleus, THF is required for de novo dTMP biosynthesis, but it is not understood how 5-methylTHF accumulation in the cytosol impairs nuclear dTMP biosynthesis.
View Article and Find Full Text PDFBackground: We have recently reported that the expression of peptidylarginine deiminase 2 (PADI2) is regulated by EGF in mammary cancer cells and appears to play a role in the proliferation of normal mammary epithelium; however, the role of PADI2 in the pathogenesis of human breast cancer has yet to be investigated. Thus, the goals of this study were to examine whether PADI2 plays a role in mammary tumor progression, and whether the inhibition of PADI activity has anti-tumor effects.
Methods: RNA-seq data from a collection of 57 breast cancer cell lines was queried for PADI2 levels, and correlations with known subtype and HER2/ERBB2 status were evaluated.