Publications by authors named "Ashley M Lopez"
The fetus can deploy a local or systemic inflammatory response when exposed to microorganisms or, alternatively, to non-infection-related stimuli (e.g., danger signals or alarmins).
View Article and Find Full Text PDFThe genome-wide transcriptional response to neonatal hyperoxia identifies Ahr as a key regulator.
Am J Physiol Lung Cell Mol Physiol
October 2014
Article Synopsis
- Premature infants on supplemental oxygen have a higher risk of developing bronchopulmonary dysplasia (BPD), and studies using neonatal rodent models exposed to high oxygen levels help explore the pathology of BPD.
- Researchers conducted RNA sequencing on mouse lungs after a 10-day exposure to 100% oxygen, discovering 300 significantly affected genes and disrupted pathways related to oxidative stress and cellular signaling.
- Key findings highlighted the Aryl Hydrocarbon Receptor (Ahr) as a critical regulator in the gene response to hyperoxia, influencing the expression of several important markers related to BPD.