Publications by authors named "Ashley M Baldwin"
Article Synopsis
- Calcific aortic valve disease (CAVD) is a prevalent heart valve condition in older populations, with two main pathways: osteogenic and dystrophic; the latter is more common.
- The study aims to develop a new 3D dystrophic calcification model that reflects cell interactions better than existing 2D models and shows that programmed cell death (apoptosis) is crucial for calcification.
- By using porcine valvular interstitial cell spheroids, researchers found that inhibiting apoptosis reduced calcification, and the addition of antioxidants (like ascorbic acid) further decreased calcification, indicating the importance of extracellular matrix production and oxidative stress in this process.
