Publications by authors named "Ashley Love Sumrall"
Background: High-grade gliomas (HGGs) are the most aggressive type of gliomas and have the poorest outcomes. Chromatin remodeling (CR) genes have been implicated in multiple oncogenic pathways in numerous cancer types. In gliomagenesis, CR genes have been implicated in regulating the stemness of glioma cells, the tumor microenvironment (TME), and resistance to therapies.
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- Recurrent glioblastoma multiforme (GBM) has a poor prognosis, but the NovoTTF-100A™ System has shown improved overall survival compared to previous trials, offering a median of 9.6 months versus 6.6 months in traditional therapies.
- Data from a post-marketing registry (PRiDe) involving 457 patients indicated that higher daily compliance and better performance status positively influenced survival rates, with higher one- and two-year survival rates compared to earlier trial results.
- Adverse events were primarily mild to moderate skin reactions, similar to those reported in prior studies, with no new safety concerns identified.