Publications by authors named "Ashley Lea"
Article Synopsis
- The study focused on a specific protein called interleukin-13 receptor alpha2 (IL-13Rα2), which is overexpressed in human solid tumors but not in normal tissues, leading to the development of a targeted anti-cancer approach using CAR-T cell technology.
- A new chimeric antigen receptor (CAR) called 14-1 was engineered, which showed a significantly stronger binding affinity to the IL-13Rα2 than a previously developed clone and was tested on T cells for effectiveness and quality.
- The results indicated that the 14-1 CAR-T cells were highly effective at targeting and killing the tumor cells expressing IL-13Rα2, leading to tumor regression in mice without causing harmful
Complex brain disorders like schizophrenia may have multifactorial origins related to mis-timed heritable and environmental factors interacting during neurodevelopment. Infections, inflammation, and autoimmune diseases are over-represented in schizophrenia leading to immune system-centered hypotheses. Complement component C4 is genetically and neurobiologically associated with schizophrenia, and its dual activity peripherally and in the brain makes it an exceptional target for biomarker development.
View Article and Find Full Text PDFSchizophrenia is a complex brain disorder with genetic and environmental factors contributing to its etiology. Complement C4 genes are schizophrenia susceptibility loci and are activated in response to infections and gut microbiome imbalances. We hypothesize that C4 genetic susceptibility predisposes individuals to neuropathological effects from pathogen exposures or a microbiome in dysbiosis.
View Article and Find Full Text PDFContext: One of the major concerns after an acute lateral ankle sprain is the potential for development of chronic ankle instability (CAI). The existing research has determined that clinician-delivered plantar massage improves postural control in those with CAI. However, the effectiveness of self-administered treatments and the underlying cause of any improvements remain unclear.
View Article and Find Full Text PDFContext: One of the major concerns after an acute lateral ankle sprain is the potential for development of chronic ankle instability (CAI). The existing research has determined that clinician-delivered plantar massage improves postural control in those with CAI. However, the effectiveness of self-administered treatments and the underlying cause of any improvements remain unclear.
View Article and Find Full Text PDF