Publications by authors named "Ashley L Huggett"
Paws and Pathogens: A Multidisciplinary Approach Through Endocarditis and Hepatosplenic T-Cell Lymphoma.
J Investig Med High Impact Case Rep
July 2024
Article Synopsis
- Gram-negative coccobacilli are important pathogens that can lead to zoonotic infections in humans, especially causing infective endocarditis, which can be hard to diagnose.
- A 23-year-old male initially misdiagnosed with lymphoma was actually suffering from blood culture-negative endocarditis linked to these bacteria, showing symptoms like fevers, pancytopenia, and heart issues despite negative blood tests.
- The case emphasizes the need for careful consideration of these pathogens in patients with suspected endocarditis and highlights the importance of serological testing and a comprehensive treatment strategy for better patient outcomes.
Background: Short courses of antibiotics (7-10 days) are effective for uncomplicated gram-negative bloodstream infections (GN-BSI). However, prior studies have been limited to small cohorts of critically ill patients.
Objective: The objective of this study was to evaluate the safety and efficacy of short courses of therapy compared with longer courses in patients admitted to the intensive care unit (ICU) with GN-BSI.